Evaluation of the risk factors associated with high-dose chemotherapy-induced dysgeusia in patients undergoing autologous hematopoietic stem cell transplantation: possible usefulness of cryotherapy in dysgeusia prevention

Okada, Naoto; Hanafusa, Takeshi; Abe, Shinji; Sato, Chiemi; Nakamura, Teruya; Teraoka, Kazuhiko; Abe, Masahiro; Kawazoe, Kazuyoshi; Ishizawa, Keisuke

doi:10.1007/s00520-016-3244-9

Cited by 33 publications

(32 citation statements)

References 19 publications

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“…Taste alterations, such as chemotherapy-induced oral mucositis, were found to be related to dysgeusia. [1,27] The present study showed higher taste alterations in patients with nausea, vomiting, loss of appetite and mucositis, corroborating previous studies.…”

Section: Characteristics Of Taste Alterationsupporting

confidence: 92%

“…Chemotherapy-induced oral mucositis causes deterioration of taste receptors. [1] Patients with oral mucositis are more likely to experience overall taste alterations, and to encounter problems, such as nausea and vomiting, changes in the sense of smell, difficulty in eating hot food/fatty food/meat, and loss of appetite, due to these alterations. Taste alterations, such as chemotherapy-induced oral mucositis, were found to be related to dysgeusia.…”

Section: Characteristics Of Taste Alterationmentioning

confidence: 99%

“…[5] Patients with small extracellular lung cancer, and receiving cisplatin and paclitaxel chemotherapy, reported a loss of appetite with bitterness and unpleasant taste in the mouth [28] The present study corroborates previous studies that indicate a loss of appetite and reduction in food intake in cancer patients who experienced taste alteration. [1,29] Limitations The most significant limitation of this study is that the research data have been collected and evaluated using patients' own statements. The empowerment of this evaluation requires experimental measures of taste perception and identification.…”

Section: Taste Alteration and Nutritionmentioning

confidence: 99%

“…Taste alteration is a common side effect in patients receiving systemic chemotherapy. [1] Taste alteration is observed in 55 to 67% of the patients receiving chemotherapy but is mostly ignored as a symptom. Many chemotherapy drugs commonly used in the treatment of cancer, such as taxane, platinum, adriamycin, and metabolites, cause taste alteration.…”

Section: Introductionmentioning

confidence: 99%

“…Inadequate food intake regarding content and amount causes malnutrition. [1,4,5] Patients with terminal cancer who experienced taste alteration were reported to have lower energy intake and experienced higher weight loss than the patients without taste alteration. Moreover, weight loss, a decrease in muscle mass, and malnutrition intensify chemotherapy-induced symptoms and negatively affect patient outcomes, quality of life, and survival rates.…”

Section: Introductionmentioning

confidence: 99%

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Taste Alteration in Cancer Patients Receiving Chemotherapy: A Cross-Sectional Study

Arıkan¹

2019

TJ Oncol

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This study aimed to investigate nutrition in cancer patients, chemotherapy-induced taste alterations and the factors affecting these taste alterations. METHODS This study was planned as a cross-sectional study. Patients who had received chemotherapy at least once and had been on chemotherapy for the last 7-10 days (n=112) were included in this study. The data were collected using the Patient-Generated Subjective Global Assessment, the National Cancer Institute's Common Terminology Criteria for Adverse Events and the Chemotherapy-induced Taste Alteration Scale (CiTAS). RESULTS The CiTAS score was higher in female cancer patients. Patients with nausea 2.19 (SD=1.00) and vomiting 3.13 (SD=1.21) had higher scores on the taste disorder subscale of the CiTAS, while patients with vomiting 3.00 (SD=1.42) had higher scores on the general taste alterations subscale (p<0.05). Patients with constipation received high scores on the subscales of reduction in intake of the basic tastes, taste disorder, and general taste alterations 2.50 (SD=1.27) (p<0.05). Patients with a lack of appetite obtained high scores on the subscales of reduction in the intake of the basic tastes, taste disorder, phantogeusia, parageusia, and general taste alterations 2.64 (SD=1.29) (p<0.05). Mild malnutrition was observed in 24.6% of the patients. CONCLUSION This study revealed that taste alteration was higher in female and early-stage patients and more severe in patients with nausea, vomiting, constipation, and mucositis. Taste alteration was found to be greater in patients with poor nutritional status.

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Section: Characteristics Of Taste Alterationsupporting

confidence: 92%

Section: Characteristics Of Taste Alterationmentioning

confidence: 99%

Section: Taste Alteration and Nutritionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Taste Alteration in Cancer Patients Receiving Chemotherapy: A Cross-Sectional Study

Arıkan¹

2019

TJ Oncol

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Preparation and application of taste bud organoids in biomedicine towards chemical sensation mechanisms

Liu

Zhu

Tian

et al. 2022

Biotech & Bioengineering

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Taste is one of the most basic and important sensations that is able to monitor the food quality and avoid intake of potential danger materials. Whether as an inevitable symptom of aging or a complication of cancer treatment, taste loss very seriously affects the patient's life quality. Taste bud organoids provide an alternative and convenient approach for the research of taste functions and the underlying mechanisms due to their characteristics of availability, strong maneuverability, and high similarity to the in-vivo taste buds. This review gives a systemic and comprehensive introduction to the preparation and application of taste bud organoids towards chemical sensing mechanisms. First, the basic structures and functions of taste buds will be briefly introduced. Then, the currently available approaches for the preparation of taste bud organoids are summarized and discussed, which are mainly divided into two categories, that is, the stem/progenitor cell-derived approach and the tissue-derived approach. Next, different applications of taste bud organoids in biomedicine are outlined based on their central roles such as disease modeling, biological sensing, gene regulation, and signal transduction.Finally, the current challenges, future development trends, and prospects of research in taste bud organoids are proposed and discussed.

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A prospective study of dysgeusia and related symptoms in patients with multiple myeloma after autologous hematopoietic cell transplantation

Scordo

Shah

Adintori

et al. 2022

Cancer

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BACKGROUND: Dysgeusia is a common but understudied complication in patients undergoing autologous hematopoietic cell transplantation (auto-HCT). We assessed the feasibility of using chemical gustometry (CG) to measure dysgeusia and explored its associations with symptom burden, nutrition, chemotherapy pharmacokinetics (PK), and the oral microbiome. METHODS: We conducted a single-center, prospective feasibility study (NCT03276481) of patients with multiple myeloma undergoing auto-HCT. CG was performed longitudinally testing five flavors (sweet, sour, salty, bitter, umami) to calculate a total taste score (maximum score, 30). We measured caloric intake and patient-reported symptoms, assessing their correlation with oral microbiota composition and salivary and blood melphalan PK exposure. RESULTS: Among all 45 patients, 39 (87%) completed at least four (>60%) and 22 (49%) completed all six CG assessments. Median total CG scores remained stable over time but were lowest at day +7 (27, range 24-30) with recovery by day +100. Symptom burden was highest by day +10 (area under the curve, 2.9; range, 1.0-4.6) corresponding with the lowest median overall caloric intake (1624 kcal; range, 1345-2267). Higher serum/salivary melphalan levels correlated with higher patient-reported dysgeusia and lower caloric intake. Oral microbiota αdiversity was stable early and increased slightly by day +100. CONCLUSIONS: Assessment of dysgeusia by CG is feasible after auto-HCT. Most dysgeusia, symptom burden, and lowest caloric intake occurred during the blood count nadir. Higher melphalan concentrations correlated with more dysgeusia and poorer caloric intake. Future studies will aim to modulate melphalan exposure by PK-targeted dosing and characterize patient taste preferences to personalize diets for improved nutritional intake.

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Evaluation of the risk factors associated with high-dose chemotherapy-induced dysgeusia in patients undergoing autologous hematopoietic stem cell transplantation: possible usefulness of cryotherapy in dysgeusia prevention

Cited by 33 publications

References 19 publications

Taste Alteration in Cancer Patients Receiving Chemotherapy: A Cross-Sectional Study

Taste Alteration in Cancer Patients Receiving Chemotherapy: A Cross-Sectional Study

Preparation and application of taste bud organoids in biomedicine towards chemical sensation mechanisms

A prospective study of dysgeusia and related symptoms in patients with multiple myeloma after autologous hematopoietic cell transplantation

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