Evaluation of the Risk of Stone
Formation: Study on Crystalluria in
Patients with Recurrent Calcium
Oxalate Urolithiasis

Robert, M; Boularan, Anne-Marie; Delbos, Olivier; Monnier, L.; Grasset, D

doi:10.1159/000473796

Cited by 16 publications

(8 citation statements)

References 18 publications

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“…In a previous study based on 24 h and fresh morning urine samples, we did not find a clear relationship between the morning calcium oxalate crystalluria and the usual parameters of evaluation of lithogenic risk [11].…”

Section: Introductioncontrasting

confidence: 88%

Study of Calcium Oxalate Crystalluria on Renal and Vesical Urines in Stone Formers and Normal Subjects

Robert¹,

Boularan

Delbos³

et al. 1998

Urol Int

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Objective: The aim of this study is to compare vesical and renal calcium oxalate crystalluria in an attempt to correlate crystal formation with chemical composition and calcium oxalate saturation of renal urine. Material and Methods: Urine specimens were directly collected from the bladder and the kidney, of 11 stone formers and 11 control subjects under general anesthesia. The type of crystals present in urine as well as their size, number by cubic millimeter and state of aggregation were determined. In addition, calcium, magnesium, sodium, chloride, phosphate, citrate, oxalate, pyrophosphate and uric acid were measured in order to evaluate the calcium saturation status (EQUIL V program). Results: Calcium oxalate crystals were detected in 3 stone formers (27%) and 2 control subjects (18%) in vesical urine and in 4 stone formers (36%) and 3 control subjects (27%) in renal urine. Only 2 stone formers presented with simultaneous renal and vesical crystalluria. Subjects of the two groups with and without renal crystalluria were compared in terms of chemical composition and calcium oxalate saturation of renal urine. Crystalluric subjects (n = 7) had significantly higher uricosuria (p = 0.02), calciuria (p = 0.04), magnesiuria (p = 0.04) and calcium oxalate molar product (p = 0.05) than noncrystalluric (n = 15); calcium oxalate saturation was similar (p = 0.5). Conclusions: Beyond theorical considerations on lithogenesis, our observations and in particular the apparent discrepancy between renal and vesical crystalluria pose the problem of the clinical interest of the evaluation of calcium oxalate crystalluria based on freshly voided urine in the assessing the lithogenic risk or in the follow-up of patients who are particularly prone to stone recurrence.

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Section: Introductioncontrasting

confidence: 88%

Study of Calcium Oxalate Crystalluria on Renal and Vesical Urines in Stone Formers and Normal Subjects

Robert¹,

Boularan

Delbos³

et al. 1998

Urol Int

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“…Employing the same reasoning, crystalluria has been used as a simple method to evaluate lithiasis severity and the efficacies of various drugs [13][14][15]. However, the use of crystalluria as a diagnostic tool to evaluate renal lithiasis remains controversial; several reports have found no correlation between crystalluria and lithogenic urine, and Validity of test data when urine samples were lithogenic or non-lithogenic according to the criteria in Table II crystalluria was reported to be poorly predictive of recurrent stone formation [16][17][18]. These apparent discrepancies challenge the current clinical interest in evaluation of calcium oxalate crystalluria in freshly voided urine and question whether it reflects lithogenic risk.…”

Section: Discussionmentioning

confidence: 99%

Urinary lithogenesis risk tests: Comparison of a commercial kit and a laboratory prototype test

Gráses

Costa-Bauzà

Prieto

et al. 2011

Scandinavian Journal of Urology and Nephrology

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“…Other results can be added, i.e. 4.2% of 122 random samples [22], 20% of 25 controls [23], < 4% of 82 normal samples [24] and 2.5% of 40 fasting controls [25] showed CaOx crystalluria. Most of these studies used centrifugation to concentrate any crystals present and viewed samples within 2 h of voiding.…”

Section: Implications Favouring the Saturated Equilibrium Hypothesis mentioning

confidence: 99%

“…CaP crystalluria in normal subjects is also a common finding, e.g. 13% of 54 subjects [30], 16% of samples from 18 subjects [31], ≈13% of 82 subjects [24], 32% of 25 controls [23], 40% of 40 fasting controls [25] and 20% of 202 samples from 16 controls [32]. While these frequencies are a little lower than the frequency of apparent CaP supersaturation amongst normal subjects (46% of cases cited in Table 1), the difference is perhaps not so great as to pose a serious challenge to the saturated equilibrium hypothesis with respect to CaP.…”

Section: Implications Favouring the Saturated Equilibrium Hypothesis mentioning

confidence: 99%

A critical appraisal of the hypothesis that urine is a saturated equilibrium with respect to stone‐forming calcium salts

Kavanagh

2001

BJU International

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Evaluation of the Risk of Stone Formation: Study on Crystalluria in Patients with Recurrent Calcium Oxalate Urolithiasis

Cited by 16 publications

References 18 publications

Study of Calcium Oxalate Crystalluria on Renal and Vesical Urines in Stone Formers and Normal Subjects

Study of Calcium Oxalate Crystalluria on Renal and Vesical Urines in Stone Formers and Normal Subjects

Urinary lithogenesis risk tests: Comparison of a commercial kit and a laboratory prototype test

A critical appraisal of the hypothesis that urine is a saturated equilibrium with respect to stone‐forming calcium salts

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