Evaluation of the role of maternal serum high sensitivity C- reactive protein correlation with total and differential leucocytic count in predicting outcome in threatened abortion

Abstract

Introduction:Miscarriage is a common complication of pregnancy occurring in 15% to 20% of all clinically recognized pregnancies. In many cases, the cause of miscarriage cannot be identified; however, among the recognized risk factors of miscarriage are maternal age over 34 years and paternal age over 40 years, previous history of two or more miscarriages, and maternal autoimmune factors.Aim of the study: Maternal serum differential leucocytic count and high-sensitivity C-reactive protein (HSCRP) were evaluated in predicting spontaneous abortion in spontaneous pregnancies presenting with threatened spontaneous abortion.Subjects and methods: 100 pregnant women were divided into two equal groups: the threatened abortion group and the control group. Results:The mean values of WBCs, neutrophils, monocytes, and lymphocytes were significantly higher in the study group. Comparing the level of High sensitivity CRP among the studied groups showed the higher significant mean values of the high sensitivity-CRP in the sera of the study group than in the control group. Conclusion:The current study recommends that increased serum levels of total and differential leucocytic count and serum levels of High sensitivity-CRP are the possible mechanisms involved in the first trimester threatened miscarriage

Evaluation of serum level of C-reactive protein (CRP) and its correlation with fetal ultrasound parameters in the prediction of threatened miscarriage in the first trimester

“…Abdelsamie et al discovered significantly higher mean values for white blood cells, neutrophils, monocytes, and lymphocytes in the study group than controls. 15 In a related context, Cohen et al aimed to investigate C-reactive protein (CRP) levels in early pregnancy to detect abnormalities, particularly ectopic pregnancy. 16 They found significantly higher CRP levels in normal pregnancy (Group A) versus abnormal pregnancies (Group B + C and Group B alone), despite no differences in age and BMI between groups.…”

“… 14 Abdelsamie et al assessed maternal serum hs-CRP and differential leukocyte count (DLC) for diagnosing threatened miscarriage in 100 pregnant women, concluding a significant difference between study groups for hs-CRP levels. 15 …”