Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base

Koto, Masashi; Hasegawa, Azusa; Takagi, Ryo; Ikawa, Hiroaki; Naganawa, Kensuke; Mizoe, Jun Etsu; Jingu, Keiichi; Tsujii, Hirohiko; Tsuji, Hiroshi; Kamada, Tadashi; Okamoto, Yoshitaka

doi:10.1002/hed.24397

Cited by 25 publications

(28 citation statements)

References 24 publications

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“…The prospective phase II COSMIC trial which evaluated combination IMRT and CIRT for incompletely resected and inoperable adenoid cystic and other malignant salivary gland tumors showed 82% local control and 78% overall survival at 3 years with acceptable toxicity [125]. Likewise, CIRT results have been published for locally advanced squamous cell carcinoma of the ear [126], lacrimal gland carcinoma [127], mucosal malignant melanoma [128], sinonasal adenocarcinoma [129] and base of tongue adenoid cystic carcinoma [130]. …”

Section: Clinical Experiences With Cirtmentioning

confidence: 99%

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

Mohamad

Sishc

Saha

et al. 2017

Cancers

148

130

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Compared to conventional photon-based external beam radiation (PhXRT), carbon ion radiotherapy (CIRT) has superior dose distribution, higher linear energy transfer (LET), and a higher relative biological effectiveness (RBE). This enhanced RBE is driven by a unique DNA damage signature characterized by clustered lesions that overwhelm the DNA repair capacity of malignant cells. These physical and radiobiological characteristics imbue heavy ions with potent tumoricidal capacity, while having the potential for simultaneously maximally sparing normal tissues. Thus, CIRT could potentially be used to treat some of the most difficult to treat tumors, including those that are hypoxic, radio-resistant, or deep-seated. Clinical data, mostly from Japan and Germany, are promising, with favorable oncologic outcomes and acceptable toxicity. In this manuscript, we review the physical and biological rationales for CIRT, with an emphasis on DNA damage and repair, as well as providing a comprehensive overview of the translational and clinical data using CIRT.

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Section: Clinical Experiences With Cirtmentioning

confidence: 99%

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

Mohamad

Sishc

Saha

et al. 2017

Cancers

148

130

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“…Mizoe and colleagues demonstrated that carbon ion irradiation was effective in the treatment of malignant melanoma and adenoid cystic carcinoma of the head and neck [139,140].…”

Section: Carbon Ion Irradiation Counteracts Cancer Stem Cells' Migratmentioning

confidence: 99%

The impact of melatonin and carbon ion irradiation on cancer stem cells

Liu¹,

Reíter²

2017

Nucl Med Biomed Imaging

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Aim: Cancer stem cells (CSCs) exhibited an excessive migratory and invasive potential. Melatonin may inhibit multiple crucial signals associated with tumor stem cell self-renewal, viability, invasiveness, tumor growth, and therapy resistance. Carbon ion irradiation may be a promising therapeutic modality in both non-stem-like and stem-like tumor cells in contrast to photon irradiation. A comprehensive understanding of the mechanisms and molecular pathways associated with invasive properties of CSCs is essential in developing novel treatment options for cancer therapy that target CSCs. Materials and methods:A systematic review of the existing literature was conducted using the following search terms: 'melatonin', 'X-ray irradiation', 'charged particle irradiation', 'carbon ion irradiation', 'cancer stem cells', 'tumor-initiating cells' and 'cancer stem-like cells'. The search used PubMed and spanned the period from January 2000 to December 2016. Conclusion:Cancer stem cells possess the capacity of self-renewal and pluripotency, generating all cells within a tumor, and are responsible for tumor growth, therapy resistance and metastasis. Melatonin attenuated AKT activation, EZH2 S21 phosphorylation, EZH2-STAT3 interactions and altered histone modifications to reduce tumor initiation and propagation of brain tumor stem cells (BTSC). Melatonin increases the efficacy of chemotherapeutic agents, targeting both the tumor bulk and BTSCs through the regulation of the expression and function of the ABCG2/BCRP transporter by inducing the methylation of its promoter. Melatonin treatment induced cell death with ultrastructural characteristics of autophagy. Breast cancer stem cells (BCSCs) are responsive to melatonin treatment by way of reducing the viability and the invasiveness of breast cancer mammospheres as well as regulating the expression of OCT4, N-cadherin and vimentin proteins associated with epithelial mesenchymal transition in BCSCs. Carbon irradiation is effective in brain tumor stem cell (BTSC) elimination with relative biologic effectiveness (RBE) in the range of 1.87-3.44. Carbon ion irradiation may be a promising therapeutic modality because it reduces migration and invasion processes in both head and neck squamous cell carcinoma and cancer stem cells in contrast to photon irradiation. Low LET X-ray irradiation may essentially eradicate the non-stem-like tumor cells, consequently the radioresistant cancer stem-like cell population is obviously enriched. In contrast, carbon ion irradiation may eradicate both non-stemlike and stem-like tumor cells at the same time. Carbon ion irradiation is a promising tool to eradicate putative colon cancer stem-like cells. Further investigation to elucidate the mechanisms and molecular pathways involved in cancer stem cells particularly associated with melatonin and carbon ion irradiation certainly is warranted.

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“… 3 , 4 However, with regard to external photon radiation therapy (RT) for tongue carcinoma, there have been no reports on the utility of spacers focused on prevention of ORN, perhaps because of the dose distribution inherent to photon RT. CIRT offers improved lateral dose distribution with minimal target exit dose 1 and thereby may benefit from the employment of a spacer-including mouthpiece.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of a Custom-Made Mouthpiece With Spacer to Reduce Osteoradionecrosis in Carbon-Ion Radiation Therapy for Tongue-Base Tumor

Ikawa

Koto

Ebner

et al. 2019

Advances in Radiation Oncology

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Evaluation of the safety and efficacy of carbon ion radiotherapy for locally advanced adenoid cystic carcinoma of the tongue base

Abstract: C-ion RT was effective with acceptable toxicities for locally advanced ACC of the tongue base. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2122-E2126, 2016.

Cited by 25 publications

References 24 publications

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair

The impact of melatonin and carbon ion irradiation on cancer stem cells

The Efficacy of a Custom-Made Mouthpiece With Spacer to Reduce Osteoradionecrosis in Carbon-Ion Radiation Therapy for Tongue-Base Tumor

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