2015
DOI: 10.1016/j.vaccine.2015.01.035
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Evaluation of the safety, immunogenicity and efficacy of three capripoxvirus vaccine strains against lumpy skin disease virus

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Cited by 93 publications
(100 citation statements)
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“…In cases where the local reactions at the vaccination site were very slight or not observed, it may also indicate that the vaccine virus was over-attenuated and therefore failed to produce an effective cell-mediated immune response. Also, highest DTH reaction responses in vaccinated calves were observed in the GC group, which indicated higher immunogenicity of the vaccine, and the lowest DTH reaction responses reaction observed with the SC group, might be related to the poor immunogenicity of the vaccines, resulting from lower antigenic similarity to LSD virus or over-attenuation resulting in genetic alteration leading to a failure in the generation of protective immunity (Tuppurainen et al, 2014;Gari et al, 2015).…”
Section: Discussionmentioning
confidence: 96%
“…In cases where the local reactions at the vaccination site were very slight or not observed, it may also indicate that the vaccine virus was over-attenuated and therefore failed to produce an effective cell-mediated immune response. Also, highest DTH reaction responses in vaccinated calves were observed in the GC group, which indicated higher immunogenicity of the vaccine, and the lowest DTH reaction responses reaction observed with the SC group, might be related to the poor immunogenicity of the vaccines, resulting from lower antigenic similarity to LSD virus or over-attenuation resulting in genetic alteration leading to a failure in the generation of protective immunity (Tuppurainen et al, 2014;Gari et al, 2015).…”
Section: Discussionmentioning
confidence: 96%
“…Lymphocyte proliferation in stimulated PBMCs is probably caused by recognition of conserved epitopes within or even between serotypes which have genetically relationship (26, 33). Lymphocyte MTT proliferation assay was chosen for estimation of cell mediated immune Response (7,30). Cell mediated immune response in vaccinated calves in goat poxvaccinated calves was higher than sheep poxvaccinated calves in all time point of experiment.…”
Section: Discussionmentioning
confidence: 99%
“…Lumpy skin disease is an infectious, eruptive, accationally fatal disaese of cattle and due to the rapid spread and ability to cause irreparable economic losses in livestock industry has been considered in "list A" of disease by OIE (3,4). The disease was first reported in 1929 in south of Africa in cattle and then spread in most of the central and northern of African countries (4)(5)(6), and recently through import of live cattle that carry the LSDV from endemic countries has been aggressively spreading in the Europe, India, south-west of Middle East and other countries (7). Several Capripoxvirus (CaPV) vaccine strains are used for the prevention and control of LSD.…”
Section: Introductionmentioning
confidence: 99%
“…This vaccine, however, caused adverse effects in 0.5% of the vaccinated cows, which was characterised by a very mild and transient LSD-like disease. A challenge study performed recently in Ethiopia showed that an attenuated Gorgon strain GTPV vaccine is effective in preventing LSD after challenge (Gari et al, 2015).…”
Section: Immune Response and Vaccines Against Lsdmentioning
confidence: 99%