Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

Kumar, Naveen; Barua, Sanjay; Kumar, Ram; Khandelwal, Nitin; Kumar, Amit; Verma, Ashu; Singh, Lokender; Godara, Bhagraj; Chander, Yogesh; Riyesh, Thachamvally; Sharma, Deepak Kumar; Pathak, Archana; Kumar, Sanjay; Dedar, R. K.; Mehta, Vishal; Gaur, Mitesh; Bhardwaj, Bhupendra; Vyas, Vithilesh; Chaudhary, Sarjeet; Yadav, Vijaypal; Bhati, Adrish; Kaul, Rakesh; Bashir, Arif; Andrabi, Anjum; Yousuf, Raja Wasim; Koul, Abhimanyu; Kachhawa, Subhash; Gurav, Amol; Gautam, Siddharth; Tiwari, Hari Audh; Gupta, M. K.; Kumar, Rajender; Misri, Jyoti; Kumar, Ashok; Mohanty, Ashok Kumar; Nandi, Sukdeb; Pal, Yash; Dutt, Triveni; Tripathi, Bhupendra Nath

doi:10.1101/2022.12.10.519851

Cited by 2 publications

(1 citation statement)

References 58 publications

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“…Salib and Osman started treatment studies in 2011 with the goal of reducing LSD consequences and saving lives. They were effective, utilizing a mix of medications that fight bacteria and inflammation, provide comfort, and treat infections [ 41 , 42 ]. They also advised to take anti-histaminic and non-steroidal anti-inflammatory medications.…”

Section: Control Measuresmentioning

confidence: 99%

An Extensive Examination of the Warning Signs, Symptoms, Diagnosis, Available Therapies, and Prognosis for Lumpy Skin Disease

Datten

Chaudhary

Sharma

et al. 2023

Viruses

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The lumpy skin disease virus (LSDV) infects cattle and buffalo and causes lumpy skin disease (LSD). It affects the lymph nodes of the sick animals, causing them to enlarge and appear as lumps (cutaneous nodules) that are 2–5 cm in diameter on their heads, necks, limbs, udders, genitalia, and perinea. A high temperature, a sharp drop in milk supply, discharge from the eyes and nose, salivation, a loss of appetite, depression, damaged hides, and emaciation are further warning signs and symptoms. As per the Food and Agriculture Organization (FAO), the incubation period, or the time between an infection and symptoms, is approximately 28 days. Infected animals can transfer the virus by direct contact with the vectors, direct virus secretion from mouth or nose, shared feeding and watering troughs, and even artificial insemination. The World Organization for Animal Health (WOAH) and the FAO both warn that the spread of illnesses could lead to serious economic losses. This illness reduces cow’s milk production because oral ulcers make the animal weak and lead them to lose their appetite. There are many diagnostics available for LSDV. However, very few tests yield accurate findings. The best methods for preventing and controlling the lumpy skin condition include vaccination and movement restrictions. As a specific cure is not available, the only available treatment for this illness is supportive care for cattle. Recently, India has developed a homologous, live-attenuated vaccine, Lumpi-ProVacInd, which is specifically intended to protect animals against the LSD virus. This study’s primary goal is to accumulate data on symptoms, the most accurate method of diagnosis, treatments, and controls to stop infections from spreading as well as to explore future possibilities for the management of LSDV.

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Section: Control Measuresmentioning

confidence: 99%

An Extensive Examination of the Warning Signs, Symptoms, Diagnosis, Available Therapies, and Prognosis for Lumpy Skin Disease

Datten

Chaudhary

Sharma

et al. 2023

Viruses

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miRNA profiling of primary lamb testicle cells infected with lumpy skin disease virus

Pandita,

Verma,

Kamboj

et al. 2023

Arch Virol

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In this study, miRNA pro ling of cells infected with lumpy skin disease virus (LSDV) was conducted for the rst time. As compared to the mock-infected cells, LSDV-infected primary lamb testicle (LT) cells revealed dysregulation of 64, 85, and 85 miRNAs at 12 hours post-infection (hpi), 48 hpi and 72 hpi, respectively. While some of these miRNAs were found to be speci cally dysregulated at a particular time point following LSDV infection, others were commonly dysregulated across all three time points. The analysis of the differentially expressed miRNA-mRNA interaction networks, Gene ontology analysis of the predicted targets and KEGG analysis of the highly enriched pathways revealed several cellular factors/pathways involved in protein/ion/enzyme binding, cell differentiation, movement of subcellular component, calcium reabsorption, aldosterone synthesis and secretion and, melanogenesis. Besides understanding virus replication, virus-host interactions and disease pathogenesis, these miRNAs and their cellular targets may serve as biomarkers as well as novel targets for therapeutic intervention against LSDV.

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Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

Cited by 2 publications

References 58 publications

An Extensive Examination of the Warning Signs, Symptoms, Diagnosis, Available Therapies, and Prognosis for Lumpy Skin Disease

An Extensive Examination of the Warning Signs, Symptoms, Diagnosis, Available Therapies, and Prognosis for Lumpy Skin Disease

miRNA profiling of primary lamb testicle cells infected with lumpy skin disease virus

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