Evaluation of the Salivary Level of Mir-21 in Cigarette Smokers: Case-Control Study

Ali, Shereen; Amer, Eman

doi:10.21608/edj.2017.74547

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…is one of the most known miRNAs to be over expressed in oral cancer, as well as being capable to distinguish between progressing and nonprogressing leukoplakias. miR-21 is considered an oncogene; it down regulates tumor suppressor genes, thus suppresses apoptosis and promotes cell proliferation (Ali and Amer, 2017).…”

Section: Genetic Markersmentioning

confidence: 99%

Salivary biomarkers and its implication in tobacco users-A narrative review

Muthu

Narayanan

2021

ijrps

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Tobacco has been associated with diverse diseases on the mouth, oral potentially malignant disorders, oral cancer and systemic diseases/cancer. The prevalence of oral cancer is high with tobacco users. The local and systemic physiology is altered by tobacco-related chemicals/metabolites. These may reflect as biomarkers of tobacco use, and they also influence the level of different biomarkers. Saliva being the initial body fluid influenced by the presence of these biomarkers and possess additional advantage to monitor, diagnose or prevent tobacco-associated illness by assessing the same. This narrative review aims to emphasize the different salivary biomarker studies and their inference on tobacco users. Articles have been collected from a different search engine, and the results were assessed to highlight their importance on human health. These markers can be further validated as diagnosing and/or predicting markers in high-risk tobacco users. In addition, the recognized readily available non-invasive salivary markers would be a great source for patient education and promoting health awareness in such groups.

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Section: Genetic Markersmentioning

confidence: 99%

Salivary biomarkers and its implication in tobacco users-A narrative review

Muthu

Narayanan

2021

ijrps

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Deciphering the Link Between Chewing Habits and Microrna 21 Dysregulation in Oral Squamous Cell Carcinoma: A Potential Cancerous Blend

Mahmood

Jamal

Alkahtani

et al. 2023

Biomed. Pharmacol. J.

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MicroRNA-21, an oncomiR, plays a pivotal role in carcinogenesis and is upregulated in many cancers including oral squamous cell carcinoma (OSCC). Use of smokeless tobacco (ST) products and cigarettes smoking in causation of OSCC is well established. This study sought to reconnoiter miR-21 expression in relation to smoking and chewing habits among subjects with oral cancer. Methods After gaining approval from IRB of Ziauddin University, analysis of miR-21 expression was conducted in 100 biopsy proven OSCC cases and 100 controls. All participants gave informed written consent after which venous blood sample was collected. qRT-PCR (Quantitative real-time Polymerase chain reaction) was performed to check miR-21 expression. SPSS Version 24 was used for analyzing the data. Results Consumption of ST was reported by 85 % and 63% were smoking cigarettes. miR-21 expression was significantly higher among smokers and those addicted to ST products, p<0.001. Subjects addicted to gutka chewing and those using more than one chewable product showed significant upregulation of miR-21, p<0.05. Amount of ST product use and smoking cigarettes was found to be positively correlated with miR-21expression. Conclusion Our study provides the evidence that use of ST products and cigarette smoking trigger miR-21 which in turn potentiate carcinogenesis in OSCC.

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Evaluation of the Salivary Level of Mir-21 in Cigarette Smokers: Case-Control Study

Cited by 2 publications

References 14 publications

Salivary biomarkers and its implication in tobacco users-A narrative review

Salivary biomarkers and its implication in tobacco users-A narrative review

Deciphering the Link Between Chewing Habits and Microrna 21 Dysregulation in Oral Squamous Cell Carcinoma: A Potential Cancerous Blend

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