Evaluation of the satiating properties of a nutraceutical product containing Garcinia cambogia and Ascophyllum nodosum extracts in healthy volunteers

Abstract

A nutraceutical product composed of a combination of Garcinia cambogia, l-carnitine and a seaweed extract of Ascophyllum nodosum has been recently developed. The aim of the present study was to characterize its effects on subjective satiety sensations and food preferences in healthy volunteers. In a crossover design, 28 subjects (21 females and 7 males, aged 31 ± 5, BMI 22.6 ± 1.7) were randomly assigned to receive the active treatment (LIS) or placebo (PL) over one week. At the end of each treatment period, subjects were instructed to consume ad libitum a test meal. Food preferences and appetite sensations were evaluated by means of the Leeds Food Preferences Questionnaire and visual analog scales, before and after meal, over three hours. There were no differences in energy intake between study groups. LIS was associated with a reduction in subjective hunger sensations (p = 0.018) and to an increase in satiety (p = 0.02) and fullness (p = 0.01) ratings. The preference for high fat foods was reduced after consuming the test meal in both study groups. There was a significant effect of LIS treatment on food explicit liking and implicit wanting, as evidenced by an increase in preference for sweet foods (relative to savory foods; p = 0.03 and p = 0.004, respectively), but no differences were observed regarding the preference for low or high fat foods (NS). These results provide proof of principle for the satiating properties of a nutraceutical containing Garcinia cambogia, Ascophyllum nodosum extract and l-carnitine and suggest that it might be useful as an appetite modulator.

Effect of orlistat alone or in combination with Garcinia cambogia on visceral adiposity index in obese patients

“…Furthermore, this study revealed a significant reduction in TC, total TG, AI, AC, CRR, and blood pressure lowering effect significantly due to the treatment with G. cambogia that led to a reduction in the visceral and subcutaneous fat accumulations regardless of gender effect [ 29 ]. This potential effect of G. cambogia was due to the effects of the active ingredient, HCA that inhibits lipogenesis and reduction in LDL levels that causing amelioration in vascular and visceral functions [ 30 ].…”

Clinical Efficacy of Brown Seaweeds Ascophyllum nodosum and Fucus vesiculosus in the Prevention or Delay Progression of the Metabolic Syndrome: A Review of Clinical Trials

“…Compared to placebo, active treatment resulted in significantly increased satiety and fullness ratings and reduced subjective hunger sensations. Concomitantly, authors reported that the active treatment was also associated with a reduction in implicit wanting and explicit liking for savoury foods and a reduction in the preference for high fat foods in both study groups [52].…”

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

“…Besides, a significant decrease in appetite and increase in hunger was seen by P. vulgaris (with dose of 100 mg/day; Spadafranca et al, ), C. fimbriata (with dose of 1,000 mg/day; Kuriyan et al, ), spinach (with dose of 5,000 mg/day; Rebello et al, , Stenblom, Egecioglu, Landin‐olsson, & Erlanson‐albertsson, ), flaxseed (with dose of 2,500 mg/day; Ibrugger, Kristensen, Mikkelsen, & Astrup, ), fenugreek (with dose of 8,000 mg/day; Mathern, Raatz, Thomas, & Slavin, ), G. cambogia (with dose of 1,000 mg/day; Mayer et al, , Preuss et al, ), green coffee (Roshan, Nikpayam, Sedaghat, & Sohrab, ), and the combination simplicifolia , asiatica , Taraxacum officinale , Cynara Scolymus , Paullina Sorbilis , Alga Klamath (Rondanelli, Klersy, Iadarola, Monteferrario, & Opizzi, ), and a combination of G. cambogia and Amorphophallus konjac (Vasques et al, ; Figure ). Some other articles have shown that Gundelia tournefortii (Hajizadeh‐Sharafabad, Alizadeh, Mohammadzadeh, Alizadeh‐Salteh, & Kheirouri, ), Coleus forskohlii (Loftus et al, ), N. sativa (Mahdavi et al, ), Garcinia atroviridis (Roongpisuthipong, Kantawan, & Roongpisuthipong, ), C. fimbriata (Kuriyan et al, ), a combination of ephedra and caffeine (Hackman et al, ) as well as a combination of walnut and flaxseed (Wu et al, ) significantly reduces energy intake (Figure ).…”