Evaluation of the seroprevalence of rubella in the region of Dakar (Senegal)

Dromigny, Jacques-Albert; Nabeth, Pierre; Claude, J. D. Perrier Gros

doi:10.1046/j.1365-3156.2003.01085.x

Cited by 24 publications

(18 citation statements)

References 12 publications

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“…The overall seroprevalence of rubella among pregnant women was found to be 89% (95% CI 86.3-91.3%). A similar finding has been reported from other African countries such as Senegal (90.1%) (Dromigny et al, 2003) and Namibia (85.0%) (Jonas et al, 2016). However, the overall seroprevalence in this study is higher than reports from other African countries like the Democratic Republic of Congo (58.97%) (Zanga et al, 2017), Sudan (65%) (Hamdan et al, 2011), and Nigeria (68%) (Bamgboye et al, 2004), and lower than reports from Burkina Faso (95%) (Tahita et al, 2013a,b) and Zimbabwe (92%) (Mamvura et al, 2015).…”

Section: Discussionsupporting

confidence: 91%

Rubella virus infections and immune status among pregnant women before the introduction of rubella vaccine in Amhara Regional State, Ethiopia

Wondimeneh

Tiruneh

Ferede

et al. 2018

International Journal of Infectious Diseases

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A large number of pregnant women had acute/recent rubella virus infections at the time of data collection, indicating that the virus is endemic in the study area. More than a tenth of pregnant women were found to be susceptible to acquiring the infection in future pregnancies, with the possible risk of rubella-associated congenital anomalies. Hence screening of all women of child-bearing age before conception and during pregnancy might reduce the devastating effects of the virus on the developing fetus.

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Section: Discussionsupporting

confidence: 91%

Rubella virus infections and immune status among pregnant women before the introduction of rubella vaccine in Amhara Regional State, Ethiopia

Wondimeneh

Tiruneh

Ferede

et al. 2018

International Journal of Infectious Diseases

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“…This seroprevalence is similar to results from two other studies carried out in Sudan and Nigeria, which showed a seroprevalence of 65-68%, respectively [18–21]. On the other hand, studies conducted in Burkinafaso, Senegal and Iran showed higher rubella seroprevalence (95.0, 90.1 and 96.2%, respectively) among pregnant women [22, 23]. Another study conducted among urban and rural pregnant women in Namibia showed an overall rubella seroprevalence of 85%, with urban women having higher risk of infection [24].…”

Section: Discussionsupporting

confidence: 88%

Rubella Seroprevalence and real-time PCR detection of RUBV among Congolese pregnant women

et al. 2017

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BackgroundRubella is an acute infectious disease caused by Rubella virus (RUBV). RUBV remains an important pathogen worldwide, causing approximately 100 000 cases of congenital rubella syndrome (CRS) every year; and the most severe consequence of rubella is teratogenicity. The aim of this study was to estimate the prevalence of RUBV IgG antibodies and determine RUBV genotypes in Congolese pregnant women in Kongo central province, Democratic Republic of Congo (DRC).MethodsThis was a prospective cross-sectional study that consisted of a laboratory analysis of blood samples from 78 pregnant women to check for the presence of RUBV IgG antibodies, and also determine RUBV genotypes in seropositive samples (using primers targeting RUBV nucleoprotein), with the use of serological and molecular methods, respectively. Participants were pregnant women attending antenatal care clinics (ANC) at two health zones of Kisantu town in DRC. They were followed-up from the first to third trimester. Those who were negative for RUBV antibodies at the initial assay (first trimester) were tested in the second and, eventually, the third trimester.ResultsAn overall rubella seroprevalence of 58.97% was observed, whereas RUBV nucleoprotein was detected in 60% of randomly selected 30 blood samples among the 46 RUBV seropositive pregnant women. Five (27.77%) of positive samples were positive for both RUBV genotypes (RV8633/9112 and RV8945/9577), whereas 11 (61.11%) of them were positive for RV8633/9112 and two (11.11%) were positive for RV8945/9577 only. Regarding rubella clinical signs and complications, two subjects (2.56%) presented with fever, whereas five pregnant women (6.41%) had experienced abortion. None (0%) of the participants has been vaccinated against RUBV.ConclusionsFindings from this study suggest that RUBV is prevalent in Congolese pregnant women. Further research is required to elucidate the molecular epidemiology of RUBV in order to design a rational rubella surveillance and control program in DRC.

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“…The rubella seropositivity obtained in this study is within this range. It is also similar to 93.5% obtained in a previous study among women of child bearing age in Oyo state by Adesina et al (8) and 90.1% obtained among women 15-45 years of age in Senegal by Dromigny et al (15). Conversely, it is at variance from a previous study by Agbede et al (12) among pregnant women at UITH, Ilorin where a value of 16.3% was obtained.…”

Section: Discussionsupporting

confidence: 90%

Rubella Antibody Avidity Among Rubella Seropositive Women Attending a Tertiary Care Facility in Nigeria

Suleiman¹,

Bakare²,

Akanbi³

et al. 2015

IJWHR

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IntroductionRubella is a vaccine-preventable disease caused by rubella virus. It is usually mild, self-limiting and may be subclinical in more than 50% of cases (1). However, when acquired during pregnancy, particularly in the first and early second trimester can infect the placenta and foetus resulting in either spontaneous abortion; stillbirth/foetal death, neonate born with congenital rubella syndrome (CRS) or congenital rubella infection (CRI) without congenital defects (2). CRS may manifest as serious foetal anomalies affecting virtually all organs, especially the eyes, ears, heart and neurological system, making it the leading cause of preventable congenital defects (3). The highest risk of CRS is found in regions with high susceptibility (low seroprevalence) rates among women of childbearing age, as presence of high circulating maternal antibody (minimum serum rubella IgG level of 10-15 IUml -1 ) which indicates immunity to rubella and virtually excludes the possibility of rubella transmission to the foetus (1). IgG antibody avidity assay (ie, the strength of IgG binding to a multivalent antigen of the virus) is an adjunct test used to distinguish recent from past infections in individuals with IgG antibodies (4). Seroprevalence of rubella varies widely between countries, different parts of the same country and overtime within a particular region of a country (5). The seroprevalence among women of reproductive age is reported as greater than 90% in most developed countries (6). Rubella seroprevalence in African region range from 71% to 99% and varied by age group (range from 84% to 94% among women of reproductive age) (6). Rubella is endemic in Nigeria (7). Studies among women of child bearing age in Nigeria put seroprevalence at 66.6% in Imo, 77% in Lagos and 93.5% in Oyo (8-10). Although data on CRS in Africa are very limited and the true burden is largely unknown, the burden of the chronic disabilities from CRS is high as these disabilities incur high treatment costs thus increasing the public health importance of Rubella (7). It has been estimated that to prevent CRS the percentage of susceptible women of child-bearing age must not exceed 5.0% (11). A recent study in this environment however put the seroprevalence of rubella among pregnant women at 16.3% (12). Thus as part of the control measure, rubella serosusceptibility especially among women AbstractObjectives: The aim of this study was to determine the seroprevalence of rubella virus antibodies among women of reproductive age group and assess risk factors of rubella infection. Materials and Methods: A cross-sectional study was carried out among 285 women aged between 15 and 49 years. Enzyme-linked immunosorbent assay (ELISA) method was used to detect and quantify human immunoglobulin G (IgG) antibodies with avidity for rubella virus in sera of participants. Socio-demographic characteristics of the participants, along with recent and previous history of fever and rash among others were obtained using a questionnaire. Statistical analysis was carri...

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Evaluation of the seroprevalence of rubella in the region of Dakar (Senegal)

Cited by 24 publications

References 12 publications

Rubella virus infections and immune status among pregnant women before the introduction of rubella vaccine in Amhara Regional State, Ethiopia

Rubella virus infections and immune status among pregnant women before the introduction of rubella vaccine in Amhara Regional State, Ethiopia

Rubella Seroprevalence and real-time PCR detection of RUBV among Congolese pregnant women

Rubella Antibody Avidity Among Rubella Seropositive Women Attending a Tertiary Care Facility in Nigeria

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