Evaluation of the serum ceruloplasmin level before and after non-surgical periodontal therapy in patients with chronic periodontitis

Mohammed, Abdulkarem A.; Youssef, Jilan M.; Metwally, Shereen S; Anees, Mohamed M.

doi:10.20517/2573-0002.2017.15

Cited by 5 publications

(5 citation statements)

References 27 publications

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“…Interestingly, serum levels of ceruloplasmin, an acute phase reactant with ferroxidase activity and involved in Cu transport, appear significantly elevated in periodontitis when compared with those from healthy controls [ 50 ]. This finding may suggest a defensive response to the oxidative stress induced by periodontal inflammation.…”

Section: Discussionmentioning

confidence: 99%

ICP-Mass-Spectrometry Ionic Profile of Whole Saliva in Patients with Untreated and Treated Periodontitis

et al. 2020

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Over the past decade, there has been growing interest in the association between macro and trace minerals in body fluids and systemic diseases related to chronic inflammation and oxidative stress. Due to the paucity of data in the literature on periodontitis, the aim of this cross-sectional study was to assess the relationship between mineral elements in saliva and periodontal status in patients with untreated and treated periodontitis compared to periodontally healthy controls. Salivary samples from 66 nonsmoker healthy patients (20 periodontally healthy, 24 untreated severe periodontitis and 22 treated severe periodontitis) were analyzed by using inductively coupled plasma mass-spectrometry (ICP-MS). Significant increases in copper (Cu), sodium (Na), iron (Fe) and manganese (Mn) concentrations occurred in saliva of severe periodontitis subjects compared to periodontally healthy controls. No differences were detected between healthy controls and treated periodontitis patients apart from levels of zinc (Zn) and lithium (Li) that were found to be increased and reduced, respectively, in periodontitis group. Most subjects were correctly separated by cluster analysis into active periodontitis and periodontally healthy individuals. Treated periodontitis individuals were classified as healthy subjects. Based on these preliminary results, the assessment of salivary concentration of mineral elements might be useful in discriminating periodontal health and disease.

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Section: Discussionmentioning

confidence: 99%

ICP-Mass-Spectrometry Ionic Profile of Whole Saliva in Patients with Untreated and Treated Periodontitis

et al. 2020

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“…In turn, the oral cavity reveals some cases of changes during this period, including: purulent granulomas, gingivitis, and periodontitis [37]. One of the biomarkers that can reveal its level change in many inflammatory conditions such as gingivitis and periodontitis is Crp, with which periodontal risk can be determined and quantified [18]. The findings of the current research revealed that the Crp levels were significantly (P a1+b1 =0.001 and P a2+b2 =0.001) increased in gingivitis patients during pregnancy (53.1±2.2 mg/dl and 0.89±0.33 mg/dl) and non-pregnant gingivitis patients (44.24±6.2 mg/dl and 0.87±0.29 mg/dl) compared with their levels in healthy control (27±4.3 mg/dl and 0.57±0.21 mg/dl) in both serum and saliva, respectively as indicated in Tables (1 and 2).…”

Section: Resultsmentioning

confidence: 99%

“…The findings of the current research revealed that the Crp levels were significantly (P a1+b1 =0.001 and P a2+b2 =0.001) increased in gingivitis patients during pregnancy (53.1±2.2 mg/dl and 0.89±0.33 mg/dl) and non-pregnant gingivitis patients (44.24±6.2 mg/dl and 0.87±0.29 mg/dl) compared with their levels in healthy control (27±4.3 mg/dl and 0.57±0.21 mg/dl) in both serum and saliva, respectively as indicated in Tables (1 and 2). The localized inflammatory state is characterized by decreased tissue oxygen content, by generation of oxygen free radicals in polymorphous neutrophils, neutrophil-mediated tissue injury, and increased OS, the fact may be that it is involved in tissue damage during the period of inflammatory conditions, and this may be due to the fact that the Crp level appears to be significantly elevated only in the presence of active tissue destruction [18,38]. This could be the reason for the elevated Crp levels in this study.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, it plays an essential role to decrease the levels of OS through its ability to scavenge for the free radicals (superoxide anion). According to several previous studies, Crp is an effective biomarker for several immunological conditions along with chronic gingivitis and has shown a strong association with periodontal disease activity [17,18]. The current study was proposed to detect the relationship between pregnancy status and the OS levels among gingivitis pregnant women and to elucidate the role of pregnancy status in the pathogenicity of gingivitis.…”

Section: Introductionmentioning

confidence: 97%

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Untitled

2022

J. Med. Chem. Sci.

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Background: Gingivitis is an inflammation limited to marginal gingival tissues, which can be referred to as the mildest form of periodontal diseases, initial signs of inflammation which include: redness, bleeding, swelling, exudation, and to a lesser extent pain, which indicate the presence of gingivitis. Current research was proposed to detect the correlation between pregnancy status and oxidative stress (OS) levels among gingivitis pregnant women and to elucidate the role of pregnancy status in the pathogenicity of gingivitis. Methods: The current study was conducted in the Dental Center at Thi-Qar province (Iraq), and it included three study groups: 35 pregnant women with gingivitis, 35 non-pregnant women with gingivitis, and 30 non-pregnant women without gingivitis (the healthy control), with an age balance between the three study groups. Serological and salivary levels of malondialdehyde (MDA), total anti-oxidant capacity (TAC), protein carbonyl (Pc), protein, nitric oxide (NO), and ceruloplasmin (Crp) were biochemically determined. Results:The results of the tests showed that the concentrations of MDA, Pc, the total proteins (TP), NO, and Crp were significantly higher among pregnant and non-pregnant women with gingivitis compared with healthy controls in both serum and saliva, whereas the inverse findings were reported for TCA biomarker. The same results profiles were reported in comparison between pregnant women with gingivitis and non-pregnant women with gingivitis for serum biomarkers. For saliva biomarkers, the results revealed significant elevated levels of MDA, Pc, and NO among pregnant gingivitis women in comparison with non-pregnant gingivitis, whereas the other biomarkers revealed non-significant differences. Conclusions: The pregnancy status had an effect on the OS level which lead to a higher level of OS in both serum and saliva and the correlation between the pregnancy status and serum and/or saliva OS levels was positive which indicated the possible utility of its present lead to gingivitis development.

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“…The explanation appears to be an increase in serum cuproenzyme, ceruloplasmin as a result of decreased catabolism of this enzyme, combined with increased compensatory antioxidant defenses in serum to combat the transformation of nonmalignant cells to malignant cells. [ 15 ]…”

Section: Discussionmentioning

confidence: 99%

Assessment of Serum Selenium and Ceruloplasmin in Potentially Malignant Disorders and Oral Cancer

Mampilly

Ravindran

Parambil

et al. 2021

Journal of Pharmacy and Bioallied Sciences

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Introduction: Despite extensive research and development, potentially malignant disorders (PMDs) of the oral cavity and oral cancer remain a serious concern. Diet and immunity have been identified as important modifiable factors in such diseases. Materials and Methods: A total of 20 patients and 10 healthy individuals, aged 30–60 years, were chosen from the outpatient Department of Oral and Maxillofacial Surgery, Yenepoya Dental College and hospital, Karnataka. The participants were grouped into three: Group 1: (10 healthy individuals), Group 2: (10 oral leukoplakia patients) and Group 3: (10 squamous cell carcinoma patients). Blood was chosen as the investigative medium. Ceruloplasmin was estimated by the diamine oxidase method. The technique of atomic absorption developed by Sir Alan Walsh in 1950 has become the preferred method of elemental analysis of selenium (atomic absorption spectrometer). Statistical analysis of the data obtained was done using one-way ANOVA test and the Turkey multiple comparisons test. Results: The intergroup comparison of ceruloplasmin shows that the mean value of Group I (Control) was 31.746 mg/dl, the mean value of Group II (leukoplakia) was 81.411 mg/dl, and the mean value of Group III (squamous cell carcinoma) was 90.7120 mg/dl. The intergroup comparison of selenium levels shows that the mean value of Group I (Control) was 119.937 (ng/ml), the mean value of Group II (leukoplakia) was 109.17 (ng/ml), and the mean value of Group III (squamous cell carcinoma) was 99.6230 (ng/ml). Conclusion: Antioxidants are an important defense system against free radical damage to cells. Ceruloplasmin and selenium levels in serum could be used as disease markers in leukoplakia and squamous cell carcinoma.

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Evaluation of the serum ceruloplasmin level before and after non-surgical periodontal therapy in patients with chronic periodontitis

Cited by 5 publications

References 27 publications

ICP-Mass-Spectrometry Ionic Profile of Whole Saliva in Patients with Untreated and Treated Periodontitis

ICP-Mass-Spectrometry Ionic Profile of Whole Saliva in Patients with Untreated and Treated Periodontitis

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Assessment of Serum Selenium and Ceruloplasmin in Potentially Malignant Disorders and Oral Cancer

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