Evaluation of the serum level of estrogen, progesterone, prolactin, and testosterone in patients with trigeminal neuralgia compared to a healthy population

Lavaee, Fatemeh; Didar, Sahar; Afshari, Aylar

doi:10.1002/cre2.815

Cited by 2 publications

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was proposed that geldings may be predisposed to trigeminally mediated headshaking syndrome (TMHS) due to the absence of normal negative feedback on springtime gonadotropin-releasing hormone (GnRH) release via testicular testosterone, leading to instability of the trigeminal nerve and the development of neuropathic pain [ 30 ]. In support of this, reproductive hormones have recently been shown to play a role in pain mediation in humans [ 31 ], and more specifically in human patients with trigeminal neuralgia [ 32 ]. While higher seasonal concentrations of gonadotropic hormones have been reported in geldings compared to stallions [ 33 , 34 ], concentrations of luteinizing hormone between HS and healthy geldings have not been shown to differ [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Equine Headshaking Syndrome: Triggers, Seasonality, and Treatment Efficacy in Australia

Bell,

Kyriazopoulou,

Mowbray

et al. 2024

Animals

View full text Add to dashboard Cite

Equine headshaking syndrome is a poorly understood neuropathic pain condition presenting as uncontrollable shaking, flicking, or striking of the head. Therapeutic options are limited, and treatments are only partially successful. Currently, epidemiological information on headshaking in the Southern Hemisphere is lacking. An online survey was circulated to Australian owners of headshaking horses to collect information on triggers, symptoms, seasonality, treatments, and perceived treatment efficacy. The responses (n = 216) showed the mean age at symptom onset as 9.6 (±4.7) years. More geldings were affected than mares (76% vs. 24%), and symptom onset occurred later in geldings compared to mares (10.1 ± 4.7 vs. 7.9 ± 4.0 years; p < 0.01). Bright sunlight, wind, and high pollen were the most commonly reported triggers (61%, 46% and 40%, respectively), and seasonal onset of symptoms was reported by 54% of respondents. In total, 71% of respondents reported using two or more treatments. The most common treatments were supplements (68%), nose nets (63%), light-blocking masks (48%), bodywork (48%) and pharmaceutical compounds (38%). Overall, treatments were considered ineffective by 33% of respondents. The findings were in agreement with surveys from the Northern Hemisphere. Of note was the perception of bright light as a primary trigger, alongside the reported low treatment efficacy of light-blocking masks. Seasonal intensification of symptoms and its relationship to day length merits further exploration.

show abstract