Evaluation of the single cervical skin test and interferon gamma responses to detect Mycobacterium bovis infected cattle in a herd co-infected with Mycobacterium avium subsp. paratuberculosis

Seva, Juan; Sanes, J.; Ramis, G.; Mas, Alberto; Quereda, J.J.; Villarreal‐Ramos, Bernardo; Villar, David; Pallarés, F. J.

doi:10.1016/j.vetmic.2014.03.035

Cited by 26 publications

(29 citation statements)

References 23 publications

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“…Studies on paratuberculosis in Latin America and the Caribbean rarely reported tuberculosis status or previous tuberculin tests before paratuberculosis testing, which could suggest that results could be higher than reported. However, single intradermal tuberculin has recently been reported to have poor sensitivity to detect positive tuberculosis cases in animals co-infected with advanced stages of paratuberculosis (Seva et al 2014). This evidence questions the usefulness of the skin test to accurately diagnose both tuberculosis and paratuberculosis.…”

Section: Discussionmentioning

confidence: 99%

Systematic review of the prevalence of paratuberculosis in cattle, sheep, and goats in Latin America and the Caribbean

Silva

Correa-Valencia

Ramı́rez

2014

Trop Anim Health Prod

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Mycobacterium avium subsp. paratuberculosis causes paratuberculosis or Johne's disease (JD) in domestic ruminants and wild species. The aim of the present study was to systematically review the prevalence of paratuberculosis among farmed animals (cattle, sheep, and goats) in Latin America and the Caribbean. The initial search for existing publications reporting systematic reviews and primary studies was carried out by searching the available databases. For the final selection of studies, an initial screen for basic eligibility and a detailed appraisal of quality were performed. After study selection, the relevant data were extracted. The detailed appraisal generated 24 publications that reported 52 studies, of which 73.1, 11.5, and 15.4 % were from cattle, sheep, and goats, respectively. Thirty-three (63.5 %) of the studies were animal level studies, while 19 (36.5 %) were herd-/flock-level studies. No flock-level studies on prevalence in sheep were found. Studies in Latin American and Caribbean countries revealed an overall prevalence of 16.9 (95 % CI (confidence interval) 13.2-20.5) and 75.8 % (95 % CI 50.1-101.5) in cattle at the animal and herd levels, respectively; the prevalence was 16 % (95 % CI 7.9-24.1) in sheep at the animal level and 4.3 % (95 % CI 1.9-6.8) and 3.7 % (95 % CI 0.1-7.4) in goats at the animal and flock levels, respectively. In general, prevalence results reported by the studies were insufficient to accurately determine the prevalence of paratuberculosis in farmed animals in Latin America and the Caribbean. Several flaws in the design of studies limit the quality of evidence regarding the prevalence of paratuberculosis in the region.

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Section: Discussionmentioning

confidence: 99%

Systematic review of the prevalence of paratuberculosis in cattle, sheep, and goats in Latin America and the Caribbean

Silva

Correa-Valencia

Ramı́rez

2014

Trop Anim Health Prod

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“…bovis may occur [21] and it may be responsible for a reduced sensitivity (Se) of the cell-mediated immune (CMI) response-based tests to detect bTB [22]. Over the last few years, antigens that are present in M .…”

Section: Introductionmentioning

confidence: 99%

Tuberculosis Detection in Paratuberculosis Vaccinated Calves: New Alternatives against Interference

et al. 2017

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Paratuberculosis vaccination in cattle has been restricted due to its possible interference with the official diagnostic methods used in tuberculosis eradication programs. To overcome this drawback, new possibilities to detect Mycobacterium bovis infected cattle in paratuberculosis vaccinated animals were studied under experimental conditions. Three groups of 5 calves each were included in the experiment: one paratuberculosis vaccinated group, one paratuberculosis vaccinated and M. bovis infected group and one M. bovis infected group. The performance of the IFN-gamma release assay (IGRA) and the skin test using conventional avian and bovine tuberculins (A- and B-PPD) but also other more specific antigens (ESAT-6/CFP10 and Rv3615c) was studied under official and new diagnostic criteria. Regarding the IGRA of vaccinated groups, when A- and B-PPD were used the sensitivity reached 100% at the first post-challenge sampling, dropping down to 40–80% in subsequent samplings. The sensitivity for the specific antigens was 80–100% and the specificity was also improved. After adapting the diagnostic criteria for the conventional antigens in the skin test, the ability to differentiate between M. bovis infected and non-infected animals included in paratuberculosis vaccinated groups was enhanced. Taking for positive a relative skin thickness increase of at least 100%, the single intradermal test specificity and sensitivity yielded 100%. The comparative intradermal test was equally accurate considering a B-PPD relative skin increase of at least 100% and greater than or equal to that produced by A-PPD. Using the specific antigens as a proteic cocktail, the specificity and sensitivity reached 100% considering the new relative and absolute cut-offs in all experimental groups (Δ≥30% and Δmm ≥ 2, respectively). Results suggest that the interference caused by paratuberculosis vaccination in cattle could be completely overcome by applying new approaches to the official tuberculosis diagnostic tests.

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“…Coinfection between MAP and M. bovis has been studied in relation to its effect on the diagnosis of bovine tuberculosis (Álvarez et al 2009;Seva et al 2014) and the serological diagnosis of MAP (Lilenbaum et al 2009), but there is a lack of information regarding husbandry management practices as facilitators for the occurrence of coinfection at both individual and herd levels. It has been reported that husbandry practices could allow the entrance of some infectious agents into a herd or the transmission among other animal population groups (Diéguez et al 2008;Humblet et al 2009;Kennedy et al 2014;Künzler et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Risk factors for Mycobacterium avium subsp. paratuberculosis (MAP) and Mycobacterium bovis coinfection at individual animal level in southern Chile cattle populations

Steuer

Raffo

Monti

et al. 2015

Trop Anim Health Prod

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Mycobacterium avium subsp. paratuberculosis (MAP) causes a chronic intestinal infection mainly in domestic and wild ruminants and is transmitted primarily by the fecal-oral route. Mycobacterium bovis (M. bovis) produces a chronic infection principally of the respiratory system. It affects most domestic mammals, wild species, and humans and is spread via the respiratory or oral route. It is important to note that M. bovis is considered a major zoonotic agent. The term coinfection refers to the coexistence of two or more infectious agents in the same host. The goal of the present study was to assess management factors that may favor coinfection with MAP and M. bovis in cattle at an individual level. A cross-sectional study was conducted including 366 cattle from 11 herds. Diagnostic information for both pathogens and individual characteristics of the animals and management practices applied on them was collected from each herd. The results indicated a set of variables being more frequent in the coinfected group of animals and mainly related with biosecurity measures. This study provided regionally based data that may be used to design future control plans for both cattle infections in southern Chile.

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Evaluation of the single cervical skin test and interferon gamma responses to detect Mycobacterium bovis infected cattle in a herd co-infected with Mycobacterium avium subsp. paratuberculosis

Cited by 26 publications

References 23 publications

Systematic review of the prevalence of paratuberculosis in cattle, sheep, and goats in Latin America and the Caribbean

Systematic review of the prevalence of paratuberculosis in cattle, sheep, and goats in Latin America and the Caribbean

Tuberculosis Detection in Paratuberculosis Vaccinated Calves: New Alternatives against Interference

Risk factors for Mycobacterium avium subsp. paratuberculosis (MAP) and Mycobacterium bovis coinfection at individual animal level in southern Chile cattle populations

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