Evaluation of the solubility of the HPMC: PVA blends in biological fluids in vitro

Bianchi, S.; Angeli, Valeria; Souza, Kellen Cristhinia Borges de; Miron, Diogo; Carvalho, Gláucio de Almeida; Santos, Venina dos; Brandalise, Rosmary Nichele

doi:10.1590/s1516-14392011005000033

Cited by 27 publications

(14 citation statements)

References 13 publications

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“…Therefore, we also prepared two‐layered HPMC/PVA‐Eudragit L100 coatings. In that case, HPMC/PVA is applied as inner layer and Eudragit L100 is applied as outer enteric coating layer to prevent the dissolution in the dissolving of drugs in the acidic stomach medium . Except chitosan, all polymers are water‐soluble above a pH of 5–6.…”

Section: Resultsmentioning

confidence: 99%

Enteric Coating Systems for the Oral Administration of Bioactive Calcium Phosphate Nanoparticles Carrying Nucleic Acids into the Colon

2020

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A system to deliver bioactive calcium phosphate nanoparticles (about 60 nm, loaded with nucleic acids) across the stomach into the colon was developed by freeze‐drying the nanoparticles in the presence of the cryoprotectant trehalose, incorporation into gelatin capsules, and coating the capsules with an enteric polymer. These capsules were stable at pH 1 (stomach conditions) and dissolved at pH 7.1 (colon conditions). The nanoparticles were released after about 60–120 min at pH 7.1. Cell culture experiments with HeLa and Caco‐2 cells showed an uptake of the nanoparticles, a transfection with EGFP‐encoding plasmid DNA, and a gene‐silencing with anti‐EGFP siRNA. From a variety of enteric coating polymers, the systems cellulose acetate phthalate (CAP), hydroxypropylmethylcellulose‐Eudragit L100, and hydroxypropylmethylcellulose‐polyvinylalcohol‐Eudragit L100 were the most suitable to accomplish the desired biological effect. The presented method is applicable for colon therapy, e. g. for an oral administration of bioactive nanoparticles which are sensitive to acidic conditions.

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Section: Resultsmentioning

confidence: 99%

Enteric Coating Systems for the Oral Administration of Bioactive Calcium Phosphate Nanoparticles Carrying Nucleic Acids into the Colon

2020

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“…The peak at 2937 cm −1 was attributed to C–H stretching vibration in an alkane. The peaks at 1048 and 1104 cm −1 are assigned to C–O stretching in hydroxyl group (Bianchi et al 2011 ; Rustemkyzy et al 2015 ). Figure 5 c shows the FTIR spectrum of film containing RB with optimized formulation.…”

Section: Resultsmentioning

confidence: 99%

New formulation and approach for mucoadhesive buccal film of rizatriptan benzoate

Salehi

Boddohi

2017

Prog Biomater

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Mucoadhesive buccal film is developed as a promising dosage form, which has prominent advantages because of drug delivery through buccal mucosa. New formulation of buccal films containing rizatriptan benzoate (RB) was prepared by solvent casting method using various concentrations of hydroxypropyl methylcellulose (HPMC K4M), polyvinyl alcohol (PVA), polyethylene oxide (PEO), glycerol, stevia, and goat buccal mucosa used as a model membrane. In this work, the effect of polymers and plasticizer concentrations on drug release profile, disintegration and dissolution time, mechanical properties, and mucoadhesive characteristics of films was studied. Scanning electron microscopy analysis revealed uniform distribution of RB in film formulations. Chemical compounds and thermal analysis of the films were studied by Fourier transform infrared spectroscopy and differential scanning calorimetry, respectively. The buccal films produced were uniform in drug content and thickness. All formulations have in vitro release of 98–102% between 40 and 80 min. Also ex vivo mucoadhesion strength was in the range of 0.205 ± 0.035 to 0.790 ± 0.014 N for all formulations. A formulation consisting RB (50 mg), HPMC K4M, PVA, and PEO (63 mg), glycerol (1.5 ml), stevia (5 mg) was selected as our optimum composition. More satisfactory results were obtained in terms of disintegration and dissolution time, mechanical properties, and mucoadhesive characteristics. In addition, it showed about 99.89% RB released in 45 min. The results suggest that RB-loaded mucoadhesive buccal films could be a potential candidate to achieve optimum drug release for effective treatment of migraine.

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“…41 Polymeric surfactants are often not counted as surfactants, however, because they occur in many formulated products (such as dispersants, emulsifiers, foam boosters, and viscosity modifiers), and could be around 10% of the surfactant market in 2000, in products as poly(ethylene oxide)-poly(propylene oxide) block copolymers, ethoxylated or sulfonated resins, carboxymethyl cellulose (CMC) and other polysaccharide derivatives, polyacrylates, xanthane, etc. 41 Carboxymethyl cellulose, generally used as a sodium salt (NaCMC), is one of the most widely used polyelectrolyte cellulose derivatives. NaCMC is an anionic, water soluble, polyelectrolyte with vast applications in the food, pharmaceutical, personal care/cosmetic, paper, and other industries.…”

Section: Discussionmentioning

confidence: 99%

Surfactant effects on wettability of Penicillium frequentans formulations to improve brown rot biocontrol

et al. 2018

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Evaluation of the solubility of the HPMC: PVA blends in biological fluids in vitro

Cited by 27 publications

References 13 publications

Enteric Coating Systems for the Oral Administration of Bioactive Calcium Phosphate Nanoparticles Carrying Nucleic Acids into the Colon

Enteric Coating Systems for the Oral Administration of Bioactive Calcium Phosphate Nanoparticles Carrying Nucleic Acids into the Colon

New formulation and approach for mucoadhesive buccal film of rizatriptan benzoate

Surfactant effects on wettability of Penicillium frequentans formulations to improve brown rot biocontrol

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