The purpose of this study was to examine the effects of psychosocial-spiritual interventions provided by Lady Hope Wellness Institute, on psychological wellbeing among cancer patients in Saint Catherine of Siena Parish at Kitisuru, Nairobi County. The objectives of the study were: to establish different types of psychosocial-spiritual interventions applied by Lady Hope Wellness Institute in facilitating psychological well-being among cancer patients, and to determine to which extent these interventions have promoted psychological well-being among these patients. This research used a mixed method approach, using survey questionnaire and interviews. It was based on a sample of 13 respondents from a total of 50 cancer patients. A purposive sampling technique was applied. Data were collected using both qualitative and quantitative methods where a questionnaire and interview were administered. Quantitative data was analyzed using descriptive statistics, with SPSS (version 25) for the management of scores, mean, frequency, percentages and tables. Content analysis was used to transcribe the qualitative data. The findings established that Lady Hope Wellness Institute used personal counseling, group counseling, prayer group meetings, meditation, religious services, medical support and social aid/ material support to foster patients Psychological Well-being (PWB). The study also revealed that the patients were experiencing a high level of flourishing in life.