Evaluation of the stability of chlortetracycline in granular premixes by monitoring its conversion into degradation products

Diana, J; Vandenbosch, Lena; Spiegeleer, Bart De; Hoogmartens, Jos; Adams, Erwin

doi:10.1016/j.jpba.2005.04.030

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…In developing the method, mainly two types of mobile phases were evaluated (1) DMSO–HClO 4 ‐water and (2) ACN–EDTA–TBAHS–water. The first mobile phase composition was based on the method of Diana et al [] used for evaluation of chlortetracycline and its degradation products and the latter was based on the method of Capote et al [] applied for separation of TC and its potential impurities. A number of experiments were carried out by changing the gradient programe (composition of the mobile phase) using each column (Section ) and both types of mobile phases.…”

Section: Resultsmentioning

confidence: 99%

Development and validation of a reversed‐phase liquid chromatographic method for analysis of demeclocycline and related impurities

Kahsay

Maxa

Schepdael

et al. 2012

J of Separation Science

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A simple, robust, and rapid reversedphase high‐performance liquid chromatographic method for the analysis of demeclocycline and its impurities is described. Chromatographic separations were achieved on a Symmetry Shield RP8 (75 mm × 4.6 mm, 3.5 μm) column kept at 40°C. The mobile phase was a gradient mixture of acetonitrile, 0.06 M sodium edetate (pH 7.5), 0.06 M tetrapropylammonium hydrogen sulphate (pH 7.5) and water, A (2:35:35:28 v/v/v/v) and B (30:35:35:0 v/v/v/v) pumped at a flow rate of 1 mL/min. UV detection was performed at 280 nm. The developed method was validated according to the ICH guidelines for specificity, limit of detection, limit of quantification, linearity, precision, and robustness. An experimental design was applied for robustness study. Results show that the peak shape, chromatographic resolution between the impurities, and the total analysis time are satisfactory and better than previous methods. The method has been applied for the analysis of commercial demeclocycline bulk samples available on the market.

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Section: Resultsmentioning

confidence: 99%

Development and validation of a reversed‐phase liquid chromatographic method for analysis of demeclocycline and related impurities

Kahsay

Maxa

Schepdael

et al. 2012

J of Separation Science

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“…HPLC has been successfully used for the quantitation of CTCs in the samples (33). CTC and its derivatives were separated on a C8 column with a retention time of 4.5 min for 4-epiTC and 5.0 min for TC (Fig.…”

Section: Quantitation Analysismentioning

confidence: 99%

Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability

et al. 2020

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The aim of this work is to improve the solubility and bioavailability of chlortetracycline and the function of the immune response. Chlortetracycline bisulfate and chlortetracycline mesylate were successfully synthesized and characterized with several techniques, including spectroscopy, chromatography and mass spectrometry, which demonstrated that the C4-dimethylamino group of chlortetracycline can accept a proton from sulfuric acid and methanesulfonic acid to form the corresponding salts. In addition, chlortetracycline bisulfate and chlortetracycline mesylate were more soluble in water than chlortetracycline hydrochloride, but the antibacterial activity was not enhanced. The influences of chlortetracycline hydrochloride, chlortetracycline bisulfate and chlortetracycline mesylate on chlortetracycline and immunoglobulin concentrations in mouse serum were also investigated. These results suggested that the chlortetracycline bisulfate and chlortetracycline mesylate have good bioavailability and strong immune response and have potential applications in animal breeding and formulation technologies.

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“…6) were identied by comparing their molar masses with previously reported compounds, such as dechlorinated chlortetracycline and dehydrated chlortetracycline. [36][37][38][39] The possible degradation pathways of CTC ( Fig. 7) and OTC (Fig.…”

Section: Possible Degradation Pathways Of Ctc and Otcmentioning

confidence: 99%

Degradation characterization and pathway analysis of chlortetracycline and oxytetracycline in a microbial fuel cell

Wang

Zhou

Ge³

et al. 2018

RSC Adv.

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Evaluation of the stability of chlortetracycline in granular premixes by monitoring its conversion into degradation products

Cited by 8 publications

References 18 publications

Development and validation of a reversed‐phase liquid chromatographic method for analysis of demeclocycline and related impurities

Development and validation of a reversed‐phase liquid chromatographic method for analysis of demeclocycline and related impurities

Synthesis and evaluation of bisulfate/mesylate-conjugated chlortetracycline with high solubility and bioavailability

Degradation characterization and pathway analysis of chlortetracycline and oxytetracycline in a microbial fuel cell

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