2020
DOI: 10.1039/d0sm00269k
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Evaluation of the subtle trade-off between physical stability and thermo-responsiveness in crosslinked methylcellulose hydrogels

Abstract: Fine-tuning of the chemical crosslinking in MC-based hydrogels increases their physical stability and mechanical properties while preserving their thermo-responsive behavior.

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Cited by 18 publications
(76 citation statements)
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“…However, MC hydrogels display some major limitations [ 12 ]. According to previous research [ 9 , 14 , 15 , 16 ], an 8% MC hydrogel prepared in 50 mM Na 2 SO 4 displays a T t ~37 °C, ideal for CSE. Nevertheless, it shows limited physical stability in the water environment (25% residual weight 7 days after immersion in dH 2 O) and low mechanical performance (G’~10 1 –10 2 Pa at 37 °C) [ 14 ].…”
Section: Introductionmentioning
confidence: 99%
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“…However, MC hydrogels display some major limitations [ 12 ]. According to previous research [ 9 , 14 , 15 , 16 ], an 8% MC hydrogel prepared in 50 mM Na 2 SO 4 displays a T t ~37 °C, ideal for CSE. Nevertheless, it shows limited physical stability in the water environment (25% residual weight 7 days after immersion in dH 2 O) and low mechanical performance (G’~10 1 –10 2 Pa at 37 °C) [ 14 ].…”
Section: Introductionmentioning
confidence: 99%
“…According to previous research [ 9 , 14 , 15 , 16 ], an 8% MC hydrogel prepared in 50 mM Na 2 SO 4 displays a T t ~37 °C, ideal for CSE. Nevertheless, it shows limited physical stability in the water environment (25% residual weight 7 days after immersion in dH 2 O) and low mechanical performance (G’~10 1 –10 2 Pa at 37 °C) [ 14 ]. In fact, when long-term cell cultures are expected, MC hydrogels’ fast dissolution could impair their application.…”
Section: Introductionmentioning
confidence: 99%
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“…A derivative of cellulose, carboxymethyl cellulose was crosslinked with citric acid and PEG which increased the mechanical strength of the fibers 29 . Another derivative of cellulose, methylcellulose has been crosslinked with citric acid showing improved mechanical properties 30 . However, the effect of various crosslinkers and in‐situ crosslinking on improving the mechanical property of wet‐spun CA fibers is largely absent in the literature.…”
Section: Introductionmentioning
confidence: 99%