Students' interest in science subjects is insufficient in different countries. One of the main reasons of decreased students' interest in science subjects is that often science subjects in schools are taught in a traditional way, separated from real life, and it is difficult for students to relate their knowledge to their personal interests. The aim of the study was to clear out Latvia students' interest in different science subjects and science subject topics. The electronic survey of Latvia students from different specialities was carried out. 12 th-grade secondary school students from two Riga schools, University of Latvia 1st course pedagogical specialities students, University of Latvia Riga Medical College 1 st course doctors' assistant program students and Latvian Academy of Music 1 st-course students were surveyed. Altogether 235 students were questioned. The results of the research showed that the interest of Latvia students from different specialities in physics and chemistry is rather low: many students have average interest in topics of these subjects. The lowest interest in physics and chemistry from surveyed student groups have Latvian Academy of Music students. The most interesting physics topic for all student groups is the structure of the Universe. From chemistry subject topics secondary school students are more interested in types of chemical reactions and electrolytic dissociation theory and carbohydrates, fats and oils. The majority of the University of Latvia pedagogical specialities students are not interested in different topics of chemistry. Most of all Latvia students are interested in biology. University of Latvia Riga Medical College doctors' assistant program students are most of all interested in biology from surveyed student groups. The most interesting topics of biology for all student groups are genetics and gene engineering, the human organism, human health, origin and evolution of life and ecology. The majority of students have average interest in such topics as construction and diversity of plants. An important task of teachers is to find out a way, how to raise students' interest in science subjects. Teachers should use a student-centred approach and interactive methods for teaching science subjects in order to achieve the personal interest of students in acquiring science subjects.