Evaluation of the therapeutic effect of micro-plasma radio frequency on hypertrophic scars in rabbit ears

Abstract

To evaluate the therapeutic effect of micro-plasma radio frequency on hypertrophic scars in rabbit ears to provide an experimental basis and theoretical foundation for the treatment of hypertrophic scars. Hypertrophic scars were established on the ventral surface of the ears of six New Zealand white rabbits. Left and right ears were randomly divided into two groups: experimental group treated with micro-plasma radio frequency and control group with no treatment. H&E staining and CD34 labeling of microvessels were performed to analyze ear specimens, and immunohistochemical staining was conducted to detect IL-8 and MCP-1 in the scars. Compared with the control group, scar tissue in the experimental group was improved by color and texture. H&E-stained collagen fiber bundles were more organized after treatment as assessed by optical microscopy. The number of microvessels in the experimental group was decreased compared with that in the control group. Microvascular density was significantly reduced in the experimental group compared with the control group (27.16 ± 5.64 and 48.75 ± 8.25 mm, respectively; P < 0.01). The mean optical densities of IL-8 and MCP-1 were significantly reduced in the experimental group compared with the control group (IL-8 0.016 ± 0.011 and 0.078 ± 0.023, respectively; MCP-1 0.018 ± 0.016 and 0.054 ± 0.038, respectively; both P < 0.01). The micro-plasma radio-frequency technique has a therapeutic effect on hypertrophic scars in rabbit ears.

Effectiveness and safety of fractional micro-plasma radio-frequency treatment combined with ablative fractional carbon dioxide laser treatment for hypertrophic scar: a retrospective study

“…Fractional micro-plasma radio-frequency technology was developed before 2008 and initially used for the treatment of facial scars and rhytids in 2010 (23,24). It was subsequently used for the treatment of post-burn facial hyperpigmentation, abdominal striae, and atrophic acne scar, and provided a promising noninvasive treatment (11,25,26). Fractional micro-plasma radio-frequency treatment also was also shown to enhance the improvement of hypertrophic scars (27).…”

“…It can trigger rapid re-epithelialization in the epidermis and accelerate the remodeling of fibroblasts. It has been reported to be effective and safe for the treatment for acne scars and hypertrophic scars (10,11). Besides, ablative fractional carbon dioxide (CO 2 ) laser treatment has also been developed for the treatment of hypertrophic scars by vaporizing water molecules and ablating scars (4).…”

The Effects of Timing of Postoperative Radiotherapy on Hypertrophic Scar in a Rabbit Model

“…Hypertrophic scars result from increased proliferation of fibroblasts with deposition of increased extracellular matrix (ECM) and collagen, angiogenesis, and chronic inflammation [ 1 , 2 ]. Ionizing radiation can directly inhibit and destroy fibroblasts and accelerate the apoptosis of fibroblasts and vascular endothelial cells resulting in the reduction of ECM and collagen deposition [ 10 – 12 ].…”

“…A rabbit model of hypertrophic scar uses injury to the rabbit ear, which can produce lesions similar to human hypertrophic scars [ 17 ]. The ventral skin of the rabbit ear has a similar structure to human skin [ 17 ].…”

“…A rabbit model of hypertrophic scar uses injury to the rabbit ear, which can produce lesions similar to human hypertrophic scars [ 17 ]. The ventral skin of the rabbit ear has a similar structure to human skin [ 17 ]. Therefore, this study aimed to investigate the association between the timing of postoperative radiotherapy and the effects on hypertrophic scar in a rabbit model.…”