Evaluation of the therapeutic effect of high-flow nasal cannula oxygen therapy on patients with aspiration pneumonia accompanied by respiratory failure in the post-stroke sequelae stage

Abstract

Background: The aim of the present study was to evaluate the therapeutic effect of high-flow nasal cannula (HFNC) oxygen therapy on patients with aspiration pneumonia accompanied by respiratory failure in the post-stroke sequelae stage, with the goal of providing more effective oxygen therapy and improving patient prognosis. Methods: Retrospective analysis was conducted on 103 elderly patients with post-stroke aspiration pneumonia and moderate respiratory failure (oxygenation index: 100–200 mmHg) that had been admitted. The patients were divided into two groups according to the mode of oxygen therapy that was used: the Venturi mask group and the HFNC treatment group. The two groups were analyzed and compared in terms of the changes in the blood gas indices measured at different points in time (4, 8, 12, 24, 48, and 72 h), the proportion of patients that required transition to invasive auxiliary ventilation, and the 28-day mortality rate. Results: A total of 103 patients were retrospectively analyzed; 16 cases were excluded, and 87 patients were included in the final patient group (42 in the HFNC group and 45 in the Venturi group). There was a statistically significant difference in the oxygenation indices of the HFNC group and the Venturi group (F = 546.811, P < 0.05). There was a statistically significant interaction between the monitored oxygenation indices and the mode of oxygen therapy (F = 70.961, P < 0.05), and there was a statistically significant difference in the oxygenation indices for the two modes of oxygen therapy (F = 256.977, P < 0.05). HFNC therapy contributed to the improvement of the oxygenation indices at a rate of 75.1%. The Venturi and HFNC groups also differed significantly in terms of the proportion of patients that required transition to invasive auxiliary ventilation within 72 h (P < 0.05). The HFNC group’s risk for invasive ventilation was 0.406 times that of the Venturi group (P < 0.05). There was no statistical difference in the 28-day mortality rate of the two groups (P > 0.05). Conclusion: HFNC could significantly improve the oxygenation state of patients with post-stroke aspiration pneumonia and respiratory failure, and it may reduce the incidence of invasive ventilation.

The efficacy of Chinese herbal medicine Buyang Huanwu Decoction combined with acupuncture to treat sequela of apoplexy

“…[4] The poststroke sequelae mainly refer to a condition left after hemorrhage of acute cerebrovascular disease, hemiplegia, numbness, skewed eyes, and poor speech. [5,6] At present, stroke, cancer, and coronary heart disease have become the 3 major diseases of human death in the world, which poses a serious threat to the safety of patients' lives and physical and mental health. In recent years, more and more reports have shown that acupuncture combined with traditional Chinese medicine has a significant effect in the treatment of sequelae of stroke, which can improve the patient's nerve function and limb function, relieve the symptoms of sequelae, and improve the quality of life of patients.…”

“…Stroke is currently the leading cause of death and disability in our population, and about 2 million strokes occur every year in China [4] . The poststroke sequelae mainly refer to a condition left after hemorrhage of acute cerebrovascular disease, hemiplegia, numbness, skewed eyes, and poor speech [5,6] . At present, stroke, cancer, and coronary heart disease have become the 3 major diseases of human death in the world, which poses a serious threat to the safety of patients’ lives and physical and mental health.…”