In this paper, an experimental setup developed for an ongoing project to investigate the hygrothermal performance of wall systems under different climate conditions is presented. As a step toward establishing the hygrothermal performance of various wood-frame wall assemblies, this research focuses on field experimentation of two types of multi-functional panels (MFPs), along with a conventional wall assembly, in two different locations in Canada: Vancouver, British Columbia, and Edmonton, Alberta. The three wall assembly types are adjacent to one another along the north- and south-facing walls of the test huts in the two cities. This experiment focuses on the effect of the various ambient weather conditions on the two innovative MFPs and on the conventional wall assembly, and on determining the long-term hygrothermal performance of the tested assemblies; it also establishes the passive solar effect on the south-facing assemblies compared to the corresponding north-oriented assemblies. Both MFPs are fixed on the exterior side of a conventional wood-frame wall assembly. The components of the first MFP are 6.4 mm Oriented Strand Board (OSB), 40 mm wood-fiber insulationäóîan environmentally-friendly and fully recyclable materialäóîand 6.4 mm OSB, while those of the second MFP are 6.4 mm OSB, 25 mm Extruded Polystyrene (XPS) core, and 6.4 mm OSB. Along with the details of the experimental setups, some sample data is presented.