Evaluation of the Toxic Potentials of Cypermethrin Pesticide on Some Reproductive and Fertility Parameters in the Male Rats

Elbetieha, Ahmed; Da’as, Sahar; Khamas, Wa; Darmani, Homa

doi:10.1007/s002440010280

Cited by 149 publications

(96 citation statements)

References 17 publications

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“…This is supported by the report that pesticide exposure is associated with infertility. There is much concern that exposure to environmental contaminants causes decreased sperm counts, impairment of sperm motility, reduced fertilization ability, producing abnormal sperm in men and wildlife [28]. In the current studies using Yankasa rams at a dose of 3mg/kg as applied in field practice in ruminants, Cypermethrin exerted almost the same negative impact on semen characteristics of the experimental rams.…”

Section: Discussionmentioning

confidence: 67%

Semen Characteristics of Yankasa Rams Following Cypermethrin Treatment

Azubuike¹,

Ogwu²,

Ibrahim³

et al. 2017

EJCBS

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This work was aimed to assess the semen characteristics of Yankasa rams following Cypermethrin treatment.Cypermethrin was used topically at the dose rate of 3mg/kg b.w (0.1ml/kg). Sixteen healthy Yankasa rams and weighing between 21.5kg and 43kg and between the ages of 18 and 30 months were used. The animals were divided into groups A and B. Group A was given 3% Cypermethrin as pour-on fortnightly for a period of twelve weeks. Group B was given distilled water at the same rate (0.1ml/kg), route of administration and period. Semen samples were collected weekly by the use of a battery powered hand held electro ejaculator. Results showed that Cypermethrin significantly reduced mean sperm concentration, motility, viability, semen volume and pH of Yankasa rams. The difference between the mean sperm motility of groups A and B in weeks 6, 7 and 8 were statistically significant (P<0.05). The values were 37.78 ± 5.21% and 82.11 ± 9.12%, 22.86 ± 4.10% and 73.42 ± 8.07%, 32.14 ± 10.17 and 67.86 ± 9.31% for groups A and B respectively. Semen volume was significantly higher in control rams at week 2 (P<0.05). The values were 0.36 ± 0.04ml and 0.93 ± 0.26 mlfor groups A and B respectively. The difference between the mean sperm concentration of groups A and B were statistically significant in weeks 5 and 7 (P<0.05). The mean sperm concentrations of groups A and B were3190 ± 499.76 x 10 6 /ml and 4558 ± 558.10 x 10 6 /ml, 1931 ± 102.57 x 10 6 /ml and 3300 ± 309.15 x 10 6 /ml for weeks 5 and 7 respectively. The difference between the mean percentage live of groups A and B were statistically significant in weeks 6, 7 and 8 (P<0.05). The values were 45.55 ± 4.75% and 82.22 ± 7.78% in week 6, 48.57 ± 5.95% and 84.29 ± 3.69% in week 7, 47.14 ± 9.44 and 74.29 ± 3.69% in week 8 for groups A and B respectively. By week 12 of the experiment, the mean semen pH values 6.60 ± 0.10 and 8.00 ± 0.09 for groups A and B respectively were significantly different (P<0.05).It was concluded that Cypermethrin lowers semen quality of Yankasa rams. It was therefore, recommended that Cypermethrin be used with caution inrams and further studies on the meat residue be done for public health concern.

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Section: Discussionmentioning

confidence: 67%

Semen Characteristics of Yankasa Rams Following Cypermethrin Treatment

Azubuike¹,

Ogwu²,

Ibrahim³

et al. 2017

EJCBS

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“…The above cited reports disagree with the findings of the current studies in relation to sperm abnormalities. There is much concern that exposure to environmental contaminants causes decreased sperm counts, impairment of sperm motility, reduced fertilization ability, producing abnormal sperm in men and wildlife (Elbetieha et al, 2001). The contrary report on sperm abnormalities in rams against many laboratory animals may be due to the species differences, route of administration and the dose of Cypermethrin.…”

Section: Discussionmentioning

confidence: 99%

“…A similar report following oral administration at a dose of 55.1 mg/kg body weight (1/5 LD 50 ) for 60 successive days have also been made (Assayed et al, 2008). Pesticide exposure is associated with infertility, there is much concern that exposure to environmental contaminants causes decreased sperm counts, impairment of sperm motility, reduced fertilization ability, producing abnormal sperm in men and wildlife (Elbetieha et al, 2001). The mechanism by which Cypermethrin affects male reproduction is unclear (Wang et al, 2009).…”

Section: Introductionmentioning

confidence: 94%

Specific sperm abnormalities observed in rams (Ovis aries) following cypermethrin treatment

Azubuike¹,

Ogwu²,

Ibrahim³

et al. 2017

J. Cell Anim. Biol.

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This work was designed to make further observations on the specific types of sperm abnormalities present in Cypermethrin treated rams and contribute information towards understanding how Cypermethrin affects male's reproduction. Sixteen sexually-mature, healthy Yankasa rams aged 18 to 30 months and weighing between 21.5 to 46.5 kg were used. The 16 rams were divided equally into two groups (A and B). Group A served as the treatment group, while B served as the control. The rams in Group A were given Cypermethrin (3%) at the dose rate of 3 mg/kg (0.1 ml/kg) body weight, topically as pour-on. The control rams were given distilled water at the same dose rate and route. These treatments were repeated every two weeks for a period of 12 weeks. Semen was collected on weekly basis from each ram during the experimental period by means of a hand held electro-ejaculator (EE). The morphological sperm abnormalities/defects were determined by examining semen smears stained with eosin-nigrosin on a glass slide. Results showed that sperm abnormalities recorded were detached head, mid piece droplet, free tail, coiled tail and bent tail. There was no significant difference in the percentage of these abnormalities recorded between the two groups (p>0.05) from week 1 to 12. It is concluded that Cypermethrin did not induce any specific sperm abnormalities in rams treated with 3 mg/kg body weight as pour-on. Sperm death in Cypermethrin label dose treated rams may be mediated through oxidative stress. It was recommended that more studies be directed towards stress biomarkers in Cypermethrin treated rams.

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“…Besides generalized toxic effects of Cypermethrin, decreased number of implantation sites, number of viable fetuses and weight gain of fetuses in rabbits treated with Cypermethrin have been reported (Elbetieha et al, 2001). Histologically, changes were observed in ovary and uterine tissues which were more pronounced at higher doses (EL-Toukhy and Girgis, 1993).…”

Section: Introductionmentioning

confidence: 98%

Scrotal circumference and body measurements of Yankasa rams following exposure to Cypermethrin

Ubah¹,

Ogwu²,

Rekwot³

et al. 2017

Afr. J. Pharm. Pharmacol.

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This work was designed to assess reproductive status of Cypermethrin treated rams by measuring the scrotal circumference, live weight, live testicular width and length as well as some physiological parameters to determine its reproductive and general toxicity in Yankasa rams. Sixteen rams aged 18 to 30 months and weighing between 21.5 and 46.5 kg were used for this study. The 16 rams were divided equally into two groups: A (treatment) and B (control). Group A were given Cypermethrin (3%) at the dose rate of 3 mg/kg (0.1 ml/kg) body weight, topically. While group (B) were given distilled water at the same dose rate and route. These treatments were repeated fortnightly for a period of 12 weeks. The animals were weighed weekly using a measuring scale early in the morning before feeding. Their rectal temperature and respiratory rates were taken concurrently. Scrotal circumference, testicular width and length were measured weekly with the use of flexible measuring tape. Results showed no statistically significant difference between the two groups in all the parameters measured (P>0.05). It was concluded that Cypermethrin at the dose rate of 3 mg/kg body weight for twelve weeks increased body weight and scrotal circumference of treated rams, although there was no significant difference between the treated and control rams (P>0.05). The treatment did not have any effect on the live testicular width and length, body temperature as well as respiratory rate of Yankasa rams studied. It was recommended that similar studies should be conducted in other domestic ruminants because species differences may play key roles in reproductive and general toxicity of Cypermethrin.

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Evaluation of the Toxic Potentials of Cypermethrin Pesticide on Some Reproductive and Fertility Parameters in the Male Rats

Cited by 149 publications

References 17 publications

Semen Characteristics of Yankasa Rams Following Cypermethrin Treatment

Semen Characteristics of Yankasa Rams Following Cypermethrin Treatment

Specific sperm abnormalities observed in rams (Ovis aries) following cypermethrin treatment

Scrotal circumference and body measurements of Yankasa rams following exposure to Cypermethrin

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