Evaluation of the toxicity of the medicinal plant Peumus Boldus during the gestational period in Wistar rats / Avaliação da toxicidade da planta medicinal Peumus Boldus durante o período gestacional de ratas Wistar

Abstract

Medicinal plants are sources of numerous compounds used in the production of drugs to treat a wide variety of symptoms. It is known that Peumus boldus, traditionally known as Boldo, has therapeutic properties applied to several digestive and liver disorders. However, as with all natural extracts, little is known about its effects on pregnancy. The literature suggests abortifacient and teratogenic effects in pregnant animals treated with P. boldus. In this sense, the present study verified the effects of commercial P. boldus extract during the gestational period in Wistar rats. The animals were divided into two groups: Control (n=3; 1 ml of distilled water) and Treated (n=6; 1.7mL/300g/day of P. boldus). Oral administration of distilled water or extract took place on days 1, 5, 10 and

Farmácia: fronteiras na pesquisa e desenvolvimento 4

“…No quadro 1 estão listadas algumas dessas espécies e seus efeitos negativos no período gestacional. Estudos relatam que uma vasta diversidade de plantas comumente utilizadas pela população brasileira, apresentam efeitos negativos ao desenvolvimento embrionário e fetal, destacando-se seu efeito abortivo, embriotóxico e teratogênico (Cassaro et al, 2021).…”