Evaluation of the Toxicological Profile of Commiphora opobalsamum in Wister Rats for Its Safety and Rational Use

Abstract

Aim: To study acute and chronic toxicity profile of Commiphora opobalsamum (CO) in rats.
 Methods: Acute oral lethal effect and single oral dose toxicity of CO was determined in rats by comparison with standard control. In contrast repeated dose oral toxicity in rats were performed in four groups of rats, CO was orally administered to three groups of rats in graded doses (250, 500 and 1000 mg/kg/day) once daily for 14 daysVs standard control. The sub-acute toxicity of CO was observed on hematological, coagulation and biochemical parameters.
 Results: Acute oral lethal dose of CO in rats was demonstrated to be safe and higher than the tested dose i.e., 2000 mg/kg, moreover, single oral dose toxicity revealed no symptoms of toxicity. Furthermore, sub-acute toxicological effect on hematological analysis of CO rats groups treated withgraded dosed after 14 days treatment revealed insignificant decrease in complete blood count (CBC)in contrast with the control group (p>0.05) additionally the biochemical parameters includedanalysis of urea, creatinine, glucose; lipid profile and thyroid function markers fairly demonstrated insignificant differences utilizing the same methodology.
 Conclusion: Our current explorative study strongly substantiates that the CO extract have no significantoral toxicity in rats and even the results of 14 days oral treatment indicated that there were no obvious toxic effects at the dosage of 1000 mg/kg/day. The comprehensive sub-acute toxicological effect of CO extracts on hematological and coagulation parameters and biochemical parameters included analysis of urea, creatinine, glucose; lipid profile and thyroid function markers fairly demonstrated no significant harmful outcome even after 14 days treatment with CO.

The Toxicity of Eichhornia crassipes Fractionated Extracts against Aphis craccivora and Its Safety in Albino Rats

“…Nevertheless, this rising is considered to be within the normal ALT range of up to 45 IU/L as reported by Derbalah et al [ 62 ]. This shows an agreement with other studies [ 54 , 63 ].…”

“…As body weight is considered one of the animal health indicators, our findings reflected a normal gradual increase in body weight, which indicated the safety of used extracts. These outcomes were in concurrence with that shown in some studies [ 53 , 54 ].…”

“…ALP is an enzymatic marker for the destruction of the plasma membrane and is used for testing its integrity [ 59 ]. The outcomes cleared a non-remarkable modification in the activity of ALP are consistent with Ahmad et al [ 54 ]. Moreover, Nwosu et al [ 60 ] had an opposite reflection as they showed that the activity of ALP was reduced in treated rats with the botanical extract.…”

An Experimental Exploratory Study for the Mechanism of Anti-Inflammatory Action of Mecca Myrrh (Commiphora opobalsamum)

“…The exclusivity of mecca myrrh -Commiphora opobalsamum (CO) is characterized by its capability of producing a resinous exudates, which possess a distinct qualities of diverse biological activities, few to illustrate as cytotoxic, analgesic, anti-inflammatory and antimicrobial effects and it is noteworthy to enlighten that its erstwhile phytochemical analysis revealed a series of terpenoids, flavonoids and sugars [20]. This essentially inspired us to execute a comprehensive experimental exploration of its anti-inflammatory and its toxicological study to put forward an effective substitute for NSAIDs [11,12]. Assessment of the anti-inflammatory effect of CO extract is one of the objectives of present study and was evaluated using experimental animal model of inflammation like carrageenan-induced paw edema because of its common utility in evaluating the antiinflammatory activity of potential active component anti-inflammatory properties [21,22].…”

“…A quite distinguishing as well as disheartening feature of currently used steroidal and Nonsteroidal anti-inflammatory drugs (NSAIDs) therapy is characterized by major threatening and fluctuating grades of gastrointestinal, renal, cardiovascular, and hepatic hazards, consequently, the treatment guidelines basically recommend that the use of NSAIDs should be done in the lowest possible dose and long-term use should be restricted wherever applicable [7][8][9][10]. Hence, the development of novel antiinflammatory agents is highly imminent, preferably from the natural herbal resources characterized with minimum side effects to substitute the current available drugs [7,8].We tried to put together an extensive research effort in the recent past to investigate the antiinflammatory effect as well as toxicological profile of Commiphora opobalsamum (CO) with the intention to unearth a safe, protective, and potent alternative from the natural resources and these studies provide distinct characteristics for the basic requirement of an ideal anti-inflammatory drug [11,12].…”