Evaluation of the use of ketoprofen for the treatment of digital dermatitis in dairy cattle: A randomised, positive controlled, clinical trial

Kasiora, Konstantina; Anagnostopoulos, Alkiviadis; Bedford, Cherril; Menka, Theologia; Barden, Matthew; Griffiths, Bethany E; Achard, Damien; Timms, Kate; Machado, V.S.; Coates, Amy; Oikonomou, Georgios

doi:10.1002/vetr.977

Cited by 6 publications

(6 citation statements)

References 22 publications

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“…Most DD treatment studies verify their efficacy based on macroscopical evaluation of lesions and lameness scoring (35)(36)(37). Ideally, however, animals should be treated before lameness occurs, and before treponemes already infiltrate deeper layers of the skin, where topical medications are less effective (38).…”

Section: Discussionmentioning

confidence: 99%

Treatment of digital dermatitis using salicylic acid in European bison (Bison bonasus) reveals promising results

Jucker¹,

Alsaaod

Steiner

et al. 2022

Front. Vet. Sci.

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Digital dermatitis (DD) associated with the presence of multiple Treponema spp. was recently described for the first time in European bison (Bison bonasus). DD is characterized by skin inflammation in the distal foot area in various ungulates. The objective of this proof of concept study was to test a treatment protocol adopted from cattle for its applicability in this wildlife species using five animals. Keratolytic salicylic acid paste was administered topically under bandages for seven days to enable removal of the affected skin. All interventions were performed under general anesthesia. To evaluate the treatment efficacy, photographs and biopsies were taken pre- and post-treatment. The biopsies were examined histologically, by PCR for the presence of different bacterial species, by Treponema-specific fluorescent in situ hybridization (FISH), and by transmission electron microscopy. Based on photographs, complete clinical healing of the 15 feet with macroscopical DD lesions was achieved. Histological examination showed mild to moderate dermatitis in 17/20 feet before, and in 12/20 feet after treatment. 17/20 feet were Treponema spp. PCR positive before, and none was positive after treatment. Dichelobacter nodosus, Fusobacterium necrophorum, and Porphyromonas levii could not be detected in any of the samples. By FISH and electron microscopy, Treponema spp. could be visualized in the stratum corneum before, but not after treatment. These results suggest that this treatment method can be applied as standard practice prior to transporting DD affected European bison to prevent the spread of this contagious disease.

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Section: Discussionmentioning

confidence: 99%

Treatment of digital dermatitis using salicylic acid in European bison (Bison bonasus) reveals promising results

Jucker¹,

Alsaaod

Steiner

et al. 2022

Front. Vet. Sci.

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“…On the other hand, high doses of TNF‐α stimulate the function of the corpus luteum, prolong the oestrus cycle (Skarzynski et al, 2003) and could thus cause both low oestrus intensity and anovulation. Lately, the role of non‐steroidal anti‐inflammatory drugs (NSAIDs) in the clinical cure of claw horn disruptions (Thomas et al, 2015) and of digital dermatitis (Kasiora et al, 2022) has been investigated, with promising results. Concurrently, NSAIDS have the potential to significantly reduce concentrations of TNF‐α and IFN‐γ in the post‐partum period (Kovacevic et al, 2019) and to improve lameness‐associated pain (Wagner et al, 2017), therefore the welfare of dairy cows.…”

Section: Modes Of Action Of Lameness On Reproductionmentioning

confidence: 99%

The negative impact of lameness on dairy cow reproduction

Tsousis

Boscos

Praxitelous

2022

Reprod Domestic Animals

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Lameness in modern dairy farms is a prevalent disorder that negatively affects all aspects of production. Additionally, is a prevailing contributor to the decreased welfare of cows. Recent research has added valuable knowledge on the negative impacts of lameness on dairy cow reproduction. Lame cows have marked behavioural changes, as well as increased inflammatory and stress indicators compared to healthy herd mates. As a result, the functioning of the hypothalamus-pituitary-ovarian axis is significantly affected and leads to suppressed reproductive performance. Lame cows seem to be more prone to uterine infections post-partum, experience higher levels of negative energy balance, resume ovarian cyclicity to a lower proportion during puerperium and show decreased potential to conceive and higher pregnancy losses.Hormonal treatments of lame cows compensate for some of these disturbances yet fail to fully restore fertility potential. From the available scientific literature is apparent that compromised fertility due to lameness can only be achieved through prevention and prompt diagnosis and treatment of lame cows.

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“…In general, active lesions are reported to be painful (Kofler et al, 2004;Higginson Cutler et al, 2013;Paudyal et al, 2020;El-Shafaey et al, 2021;Kasiora et al, 2022), with M2 lesions considered most painful (Holzhauer et al, 2008;Schultz and Capion, 2013). It is important to note that Higginson Cutler et al (2013) reported not only active, but also healing lesions of digital dermatitis to be painful.…”

Section: Pain and Lamenessmentioning

confidence: 99%

“…As a result of the differences in pain associated with lesion stages and nociceptive thresholds in cattle, the degree of lameness related to digital dermatitis lesions varies greatly among studies, ranging between 2 and 80% (Kofler et al, 2004;Capion et al, 2009;Frankena et al, 2009;Tadich et al, 2010;Schulz et al, 2016;Sadiq et al, 2017;Hässig et al, 2018;Moreira et al, 2018b;Sellera et al, 2021;Kasiora et al, 2022). A few studies highlight specific aspects of the association between digital dermatitis and lameness.…”

Section: Pain and Lamenessmentioning

confidence: 99%

“…Following topical treatment of digital dermatitis lesions, cows on average remain lame for 2.4 weeks (Schulz et al, 2016). The addition of a non-steroidal anti-inflammatory drug to the treatment of active digital dermatitis lesions in lame cows, decreased the odds to remain lame one week post treatment (Kasiora et al, 2022). In tie stalls, digital dermatitis lesions result in weight shifting (Jewell et al, 2021), a clinical sign often described as cows standing on tiptoes, which is also seen while cows are in the milking parlor or at the feed rail.…”

Section: Pain and Lamenessmentioning

confidence: 99%

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Diagnosis, treatment, and control of bovine digital dermatitis in dairy cattle

Vanhoudt¹

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This thesis focuses on the detection, prompt effective treatment, and control of digital dermatitis (DD) on dairy herds. In Chapter 2, an overview of the status quo on management of DD on dairy herds is given. In Chapter 3 we demonstrated that experienced scorers are well able to differentiate between photographs of feet affected by DD and photographs feet unaffected by DD. On the other hand, they were less able to identify specific lesion stages, including the M2 and M4 stage which are considered important stages regarding clinical impact and infection reservoir, respectively. In Chapter 4 we concluded that infrared thermography (IRT) is unlikely to be suited for automated identification of feet affected by DD due to the poor associations between maximum temperature of the plantar pastern region and the presence of M2 lesions or DD lesions in general. In Chapter 5 we demonstrated that topical treatment of active, often painful, DD lesions with a copper and zinc chelates gel (coppergel) and bandage outperformed an enzyme alginogel and bandage in M-score improvement, with the majority of lesions transitioning to the chronic, often not painful, state. In contrast, treatment with the alginogel achieved improved wound healing progress compared with the coppergel. However, neither the coppergel nor the alginogel achieved high cure rates to healthy skin. In Chapter 6 we illustrated that a standalone identification of risk factors for DD together with associated advice to control these risk factors is insufficient to decrease the prevalence of DD in dairy herds. Chapter 7 concludes this thesis with a general discussion providing a reflection on insights gained and suggestions for future research on the diagnosis, treatment, and control of digital dermatitis in dairy herds.

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Evaluation of the use of ketoprofen for the treatment of digital dermatitis in dairy cattle: A randomised, positive controlled, clinical trial

Cited by 6 publications

References 22 publications

Treatment of digital dermatitis using salicylic acid in European bison (Bison bonasus) reveals promising results

Treatment of digital dermatitis using salicylic acid in European bison (Bison bonasus) reveals promising results

The negative impact of lameness on dairy cow reproduction

Diagnosis, treatment, and control of bovine digital dermatitis in dairy cattle

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