Evaluation of the use of rapid urease test: Pronto Dry to detect<i>H pylori</i>in patients with dyspepsia in several cities in Indonesia

Af, Syam; Abdullah, Murdani; Rani, AA; Nurdjanah, Siti; Adi, Pangestu; Djumhana, Ali; P, Tarigan; Wibawa, Idn

doi:10.3748/wjg.v12.i38.6216

Cited by 8 publications

(12 citation statements)

References 9 publications

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“…However, a previous report found that the prevalence of H. pylori infection in Indonesia was quite low (10·2%) even when patients taking proton pump inhibitors were excluded from the study population [22]. First, we could not obtain information about medications used by the study participants.…”

Section: Discussionmentioning

confidence: 96%

“…However, the reported prevalence ranged from 0% to 68% [4,5]. Six studies included patients with dyspepsia [5,[20][21][22][23][24], whereas three other studies included study participants from the general population [4,19,25]. Six studies included patients with dyspepsia [5,[20][21][22][23][24], whereas three other studies included study participants from the general population [4,19,25].…”

Section: Discussionmentioning

confidence: 99%

“…These differences might be attributed to the different study populations and different tests for H. pylori infection. In nine studies, five used histological examination for diagnosis [5,[20][21][22][23]. In nine studies, five used histological examination for diagnosis [5,[20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

“…Six studies included patients with dyspepsia [5,[20][21][22][23][24], whereas three other studies included study participants from the general population [4,19,25]. Four studies reported low infection rates (5·7-12·8%) [20][21][22][23]. Four studies reported low infection rates (5·7-12·8%) [20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

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Identification ofHelicobacter pyloriinfection in symptomatic patients in Surabaya, Indonesia, using five diagnostic tests

et al. 2014

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SUMMARY The prevalence of Helicobacter pylori infection in Indonesia is controversial. We examined the H. pylori infection rate in 78 patients in a hospital in Surabaya using five different tests, including culture, histology, immunohistochemistry, rapid urease test, and urine antibody test. Furthermore, we analysed virulence factors in H. pylori strains from Indonesia. The H. pylori infection rate was only 11.5% in all patients studied, and 2.3% of Javanese patients and 18.0% of Chinese patients were infected (P = 0.01). Although severe gastritis was not observed, activity and inflammation were significantly higher in patients positive for H. pylori than in patients negative for H. pylori. Among genotypes identified from five isolated strains, cagA was found in four; two were vacA s1m1. All cagA-positive strains were oipA 'on' and iceA1 positive. We confirmed both a low H. pylori infection rate and a low prevalence of precancerous lesions in dyspeptic patients in a Surabaya hospital, which may contribute to the low incidence of gastric cancer in Indonesia.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Identification ofHelicobacter pyloriinfection in symptomatic patients in Surabaya, Indonesia, using five diagnostic tests

et al. 2014

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show abstract

“…It is possible that we have included patients who had been administered antibiotics, histamine-2 receptor antagonists (H2-blockers), or proton pump inhibitors, which can influence H. pylori infection prevalence. However, a previous report found the prevalence of H. pylori infection in Indonesia to be quite low (10.2%) even after patients taking proton pump inhibitors were excluded from the study population [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Extremely low Helicobacter pylori prevalence in North Sulawesi, Indonesia and identification of a Maori-tribe type strain: a cross sectional study

et al. 2014

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BackgroundSulawesi in Indonesia has a unique geographical profile with assumed separation from Sundaland. Studies of Helicobacter pylori in this region are rare due to the region’s rural location and lack of endoscopy equipment. Indirect methods are, therefore, the most appropriate for measuring H. pylori infection in these areas; with the disposable gastric brush test, we can obtain gastric juice as well as small gastric tissue samples for H. pylori culture. We investigated the prevalence of H. pylori infection and evaluated human migration patterns in the remote areas of North Sulawesi.MethodsWe recruited a total of 251 consecutive adult volunteers and 131 elementary school children. H. pylori infection was determined by urine antibody test. A gastric brush test was used to culture H. pylori. We used next-generation and polymerase chain reaction based sequencing to determine virulence factors and multi-locus sequence typing (MLST).ResultsThe overall H. pylori prevalence was only 14.3% for adults and 3.8% for children, and 13.6% and 16.7% in Minahasanese and Mongondownese participants, respectively. We isolated a single H. pylori strain, termed -Manado-1. Manado-1 was East Asian type cagA (ABD type), vacA s1c-m1b, iceA1 positive/iceA2 negative, jhp0562-positive/β-(1,3) galT-negative, oipA “on”, and dupA-negative. Phylogenetic analyses showed the strain to be hspMaori type, a major type observed in native Taiwanese and Maori tribes.ConclusionsOur data support that very low H. pylori infection prevalence in Indonesia. Identification of hspMaori type H. pylori in North Sulawesi may support the hypothesis that North Sulawesi people migrated from north.

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Factors associated with health-related quality of life in patients with functional dyspepsia

Hantoro

Syam

Mudjaddid

et al. 2018

Health Qual Life Outcomes

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BackgroundHealth-related quality of life (HRQoL) assessment is important for patients with functional dyspepsia. However, no studies have assessed factors associated with HRQoL reduction in such patients in an Asian population. This study aimed to determine the contribution of clinical, psychosocial, and demographic factors to HRQoL in affected patients in Indonesia.MethodsIn a cross-sectional study, we recruited 124 patients in a tertiary hospital with functional dyspepsia according to Rome III criteria. HRQoL was measured using the Medical Outcomes Study Short-Form 36 (SF-36) physical component summary (PCS) and mental component summary (MCS) and compared with 2009 United States population norms. The factors investigated were age, gender, symptom severity, education level, employment status, anxiety, depression, and ethnicity. Factors associated with reduced HRQoL were identified using linear regression analysis.ResultsAll domains of HRQoL except vitality were impaired in patients with functional dyspepsia. The mean PCS was 42.3 (SD = 8.4); and the mean MCS was 47.8 (SD = 10). Increasing age (p = 0.002), female gender (p = 0.006), low-to-mid education level (p = 0.015) and greater symptom severity (p < 0.001) were significantly associated with impaired PCS (R2 = 0.36). Female gender (p = 0.047), greater symptom severity (p = 0.002), anxiety (p = 0.001), and depression (p = 0.002 were all significantly associated with an impaired MCS (R2 = 0.41). There were no significant associations between HRQoL and with ethnic group (Javanese/non-Javanese) or employment status.ConclusionsThere was significant HRQoL impairment in these patients with functional dyspepsia in Indonesia. Anxiety, depression, increasing age, female gender, greater symptom severity, and low-to-mid education level were significant factors associated with low HRQoL. Trial registrationClinicalTrials.gov NCT03321383. Registered 18 October 2017 retrospectively registered.

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Evaluation of the use of rapid urease test: Pronto Dry to detectH pyloriin patients with dyspepsia in several cities in Indonesia

Abstract: Pronto Dry seems promising as a diagnostic tool to detect H pylori more rapidly and accurately.

Cited by 8 publications

References 9 publications

Identification ofHelicobacter pyloriinfection in symptomatic patients in Surabaya, Indonesia, using five diagnostic tests

Identification ofHelicobacter pyloriinfection in symptomatic patients in Surabaya, Indonesia, using five diagnostic tests

Extremely low Helicobacter pylori prevalence in North Sulawesi, Indonesia and identification of a Maori-tribe type strain: a cross sectional study

Factors associated with health-related quality of life in patients with functional dyspepsia

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