Evaluation of the value of the first and third trimester maternal mean platelet volume (MPV) for prediction of pre-eclampsia

Objective To compare the neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and platelet indices between women with pre‐eclampsia and normotensive pregnant women. Methods A cross‐sectional study conducted from January to July 2017 at a tertiary care hospital in Delhi, India. The study compared pregnant women aged 18–40 years with pre‐eclampsia diagnosed at term with healthy pregnant women matched for gestational age. Venous blood samples were drawn and complete blood count was analyzed. The parameters recorded were hemoglobin, red cell distribution width (RDW), platelet count, mean platelet volume (MPV), plateletcrit, and platelet distribution width. Results There were 67 women included in each group. NLR was higher in women with pre‐eclampsia compared with the control group (6.8 ± 7.6 vs 3.0 ± 0.98; P=0.001). Both PLR (14.18 ± 14.4 vs 9.54 ± 3.6; P=0.012) and MPV (9.45 ± 1.19 vs 9.02 ± 1.1; P=0.029) were higher in the study group compared with the control group. Platelet count was lower in pre‐eclamptic women compared with the control group (188 ± 89.7 vs 200.1 ± 62.36; P=0.014). RDW was also higher in the study group (P=0.025). Conclusions The present study found that the inflammatory markers NLR, PLR, RDW, and MPV were higher in women with pre‐eclampsia. Measuring NLR and PLR may be useful in predicting pre‐eclampsia among women at high risk during prenatal follow‐up.

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“…These results were similar to those of Vilchez et al . and Kashanian et al . who also concluded that MPV is raised in pre‐eclampsia.…”

Section: Discussionsupporting

confidence: 92%

“…showed that NLR was not significantly elevated in severe pre‐eclampsia when compared with healthy nonpregnant patients . Kashanian et al . reported that MPV was significantly elevated in pre‐eclampsia, which contrasted with the results of Yavuzcan et al .…”

Section: Introductionmentioning

confidence: 82%

Neutrophil‐to‐lymphocyte ratio and platelet indices in pre‐eclampsia

Gogoi

Sinha

Gupta

et al. 2018

Intl J Gynecology & Obste

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“…Its predictive role in several important medical conditions such as coronary artery disease, stroke, and thromboembolic events has recently been demonstrated . In obstetrics, current literature regarding the role of MPV in the prediction of pre‐eclampsia is controversial . Given that thrombocytopenia is considered a laboratory marker of diagnosis and severity of pre‐eclampsia, and platelet volume changes are more sensitive and occur earlier than changes in platelet count, the study of MPV as a biomarker deserves special consideration.…”

Section: Introductionmentioning

confidence: 99%

Is mean platelet volume a better biomarker in pre‐eclampsia?

Vilchez

Lagos

Kumar

et al. 2017

J of Obstet and Gynaecol

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“…The platelet/lymphocyte (P/L) ratio provides a simple, important method to evaluate systemic inflammation. Mean platelet volume (MPV), which is an indicator of platelet function and systemic inflammation, has been found to be associated with obstetrics disorders such as preterm premature rupture of the membranes and preeclampsia [9,10]. To our knowledge, there are no published data on the association of platelet indices such as plateletcrit, MPV, platelet distribution width (PDW), and P/L ratio with first trimester miscarriage.…”

Section: Introductionmentioning

confidence: 99%

Association between platelet indices and first trimester miscarriage

Akin

Kasap²,

Yuvacı³

et al. 2016

Blood Coagulation &Amp; Fibrinolysis

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We aimed to measure the effect of several potential risk factors on first trimester miscarriage. A total of 169 cases were included in the present study. Patients were selected from women who had first trimester miscarriage (n = 78) and controls were selected from the women who had given birth at term (> 37 weeks of gestation) to healthy infants (n = 91). Compared with the control group, in the miscarriage group gestational age (8.9 ± 2.8 weeks and 8.1 ± 2.2 weeks, respectively, P = 0.032), mean platelet volume (MPV) (8.8 ± 1 and 9.5 ± 1.1 fl, respectively, P < 0.001), plateletcrit (0.209 ± 0.03% and 0.241 ± 0.05%, respectively, P < 0.001), and platelet/lymphocyte ratio (128 ± 37 and 145 ± 60, respectively, P = 0.027) were significantly higher. Multivariate analysis showed that first trimester miscarriage development ratio was 1.909 times higher when MPV value was over 9.1 fl (P < 0.001); 9.147 times higher when plateletcrit value was over 0.219% (P = 0.022). Receiver operating characteristic analysis was performed to determine diagnostic MPV and plateletcrit values for first trimester miscarriage. MPV value greater than 9.1 fl determined miscarriage with 60% sensitivity and 65% specificity, while plateletcrit value greater than 0.219% determined miscarriage with 64.5% sensitivity and 64.7% specificity. MPV and plateletcrit values were strongly associated with first trimester miscarriage. Platelet indices can be used for prediction of fetal loss.

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Evaluation of the value of the first and third trimester maternal mean platelet volume (MPV) for prediction of pre-eclampsia

Cited by 27 publications

References 14 publications

Neutrophil‐to‐lymphocyte ratio and platelet indices in pre‐eclampsia

Neutrophil‐to‐lymphocyte ratio and platelet indices in pre‐eclampsia

Is mean platelet volume a better biomarker in pre‐eclampsia?

Association between platelet indices and first trimester miscarriage

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