Human activities continue to impact the Romanian Black Sea, with implications for the marine ecosystem. This study presents new data (2023) on the spatial distribution of heavy metals, persistent organic pollutants, and nutrients in Romanian Black Sea waters. Our findings reveal the influence of various pollution sources, including the Danube River, municipal and industrial discharges, and maritime activities. Nutrient loads, primarily from the Danube and diffuse sources, exert pressure on the pelagic habitat. While there has been some improvement in nutrient conditions, the potential for increased eutrophication due to climate change remains a concern. Understanding the spatial distribution of pollutants and identifying their sources is crucial for developing effective management strategies to protect the marine environment.