Evaluation of the wound-healing potential of the kiwifruit extract by assessing its effects on human gingival fibroblasts and angiogenesis

Rahman, Sartaz; Karibasappa, Sowmya Nagur; Mehta, Dhoom Singh

doi:10.17219/dmp/146635

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…Kiwifruit has been known to have protein-dissolving enzymes, called actinidin, ascorbic acid, pro-angiogenic and antibacterial agents. These ingredients are essential in ulcer healing processes (Hafezi et al, 2010;Mohajeri et al, 2010Mohajeri et al, , 2015 and may enhance wound healing by increasing angiogenesis and fibroblast migration (Rahman et al, 2023). Following the success in showing effectiveness of kiwifruit in treating second-degree burns in rats (Mohajeri et al, 2010), a randomized clinical trial of kiwifruit extract healed foot ulceration and chronic bedsores faster than the standard treatment, and the collagen and granulation tissue were significantly higher in the treated groups (Mohajeri et al, 2010(Mohajeri et al, , 2015.…”

Section: Includedmentioning

confidence: 99%

Plants with cosmetic uses

Mansoor,

Aburjai,

Al‐Mamoori

et al. 2023

Phytotherapy Research

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The use of plants as a source of active principles for cosmetics has significantly increased in the last few years. Safety, compatibility with all types of skin, fewer side effects, and availability are among the advantages of herbal cosmetics above synthetic ingredients. The present review aims to explore the most important plants used in cosmetics. A literature search was carried out in several electronic databases with the following phrases: skincare and plants; cosmetics and plants; natural and cosmetics; and natural and skincare. Furthermore, more detailed filters such as clinical studies, meta‐analyses, and systemic reviews were applied to positive results. Various plants and plant extracts currently used in skin care, scaring, whitening, and aging, as well as in sun protection, acne, eczema, and others, have been included in this review. The effectiveness of these plants is based mainly on preclinical research, and to a lesser extent on clinical studies. Some plant extracts or oils have been tested clinically, such as onions, aloe, and tea tree oil, more than other plant extracts. Despite many studies on natural products to improve dermal needs, proper clinical cosmeceutical trials are much fewer than expected. Therefore, more clinical trials are needed to evaluate appropriate efficacy. Furthermore, new formulation technologies might enhance the cosmeceutical benefits, but more work is warranted.

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Section: Includedmentioning

confidence: 99%

Plants with cosmetic uses

Mansoor,

Aburjai,

Al‐Mamoori

et al. 2023

Phytotherapy Research

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“…Considering the facts presented so far, including the important role of GMSCs in physiological and pathological conditions, the question arises regarding how pomegranate peel extract (PoPEx) affects GMSCs because such data are missing in the literature. In this context, a paper showed that kiwifruit extract enhanced the proliferation and migration of human gingival fibroblasts and promoted angiogenesis [34]. In addition, a pomegranate extract and punicallagin exerted antioxidant properties on human gingival fibroblasts but inhibited their proliferation at higher concentrations [35].…”

Section: Introductionmentioning

confidence: 99%

Pomegranate Peel Extract Differently Modulates Gene Expression in Gingiva-Derived Mesenchymal Stromal Cells under Physiological and Inflammatory Conditions

Čolić,

Miljuš,

Đokić

et al. 2023

IJMS

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Pomegranate has shown a favorable effect on gingivitis/periodontitis, but the mechanisms involved are poorly understood. The aim of this study was to test the effect of pomegranate peel extract (PoPEx) on gingiva-derived mesenchymal stromal cells (GMSCs) under physiological and inflammatory conditions. GMSC lines from healthy (H) and periodontitis (P) gingiva (n = 3 of each) were established. The lines were treated with two non-toxic concentrations of PoPEX (low—10; high—40 µg/mL), with or without additional lipopolysaccharide (LPS) stimulation. Twenty-four genes in GMSCs involved in different functions were examined using real-time polymerase chain reaction (RT-PCR). PoPEx (mostly at higher concentrations) inhibited the basal expression of IL-6, MCP-1, GRO-α, RANTES, IP-10, HIF-1α, SDF-1, and HGF but increased the expression of IL-8, TLR3, TGF-β, TGF-β/LAP ratio, IDO-1, and IGFB4 genes in H-GMSCs. PoPEx increased IL-6, RANTES, MMP3, and BMP2 but inhibited TLR2 and GRO-α gene expression in P-GMSCs. LPS upregulated genes for proinflammatory cytokines and chemokines, tissue regeneration/repair (MMP3, IGFBP4, HGF), and immunomodulation (IP-10, RANTES, IDO-1, TLR3, COX-2), more strongly in P-GMSCs. PoPEx also potentiated most genes’ expression in LPS-stimulated P-GMSCs, including upregulation of osteoblastic genes (RUNX2, BMP2, COL1A1, and OPG), simultaneously inhibiting cell proliferation. In conclusion, the modulatory effects of PoPEx on gene expression in GMSCs are complex and dependent on applied concentrations, GMSC type, and LPS stimulation. Generally, the effect is more pronounced in inflammation-simulating conditions.

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A critical overview of challenging roles of medicinal plants in improvement of wound healing technology

Pathak,

Mazumder

2024

DARU J Pharm Sci

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Evaluation of the wound-healing potential of the kiwifruit extract by assessing its effects on human gingival fibroblasts and angiogenesis

Cited by 6 publications

References 25 publications

Plants with cosmetic uses

Plants with cosmetic uses

Pomegranate Peel Extract Differently Modulates Gene Expression in Gingiva-Derived Mesenchymal Stromal Cells under Physiological and Inflammatory Conditions

A critical overview of challenging roles of medicinal plants in improvement of wound healing technology

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