Evaluation of the Xal-Ease™ latanoprost delivery system

Semes, Leo; Shaikh, Adam S.

doi:10.1016/j.optm.2006.06.016

Cited by 10 publications

(10 citation statements)

References 16 publications

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“…Semes and Shaikh17 found better use of the drops with the device (greater number of drops per bottle) when compared to conventional use. The authors attributed their results to a more uniform individual volume of each drop obtained with the device 17. In another study, with a more robust design (multicenter, prospective, randomized, crossover), Nordmann et al18 observed that the use of the device halved the need for additional help to instill eye drops as compared to conventional use.…”

Section: Discussionmentioning

confidence: 96%

“…In comparison with the conventional use of Xalatan and Xalacom eye drops (both from Pfizer Ophthalmics), different studies showed significant benefits with the use of the device 17,18. Semes and Shaikh17 found better use of the drops with the device (greater number of drops per bottle) when compared to conventional use. The authors attributed their results to a more uniform individual volume of each drop obtained with the device 17.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the efficacy and safety of a new device for eye drops instillation in patients with glaucoma

Junqueira¹,

Lopes²,

Souza³

et al. 2015

OPTH

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ObjectiveThis study evaluated the efficacy and safety of a new device (Eyedrop®) designed for eye drop instillation in patients with and without glaucoma.MethodsThis prospective study included consecutive patients with glaucoma and healthy participants. After a complete eye examination and determination of baseline intraocular pressure (IOP), topical hypotensive medication was introduced in both eyes, and the Eyedrop® delivery device (a plastic device in which the bottle with eye drops is inserted) was made available to all participants (with video and written instructions) for use in one eye, randomly chosen. In the second phase, all patients were evaluated by an experienced examiner for IOP determination, investigation of possible associated side effects, and ease of instilling eye drops (by a visual analog scale [VAS]; 0–10).ResultsThirty two participants (mean age 42.3±16.2 years) were evaluated. Of these, 44% had glaucoma. There was no significant difference in mean IOP variation when comparing the eye using (−3.9±2.9 mmHg) or not using the device (−3.3±2.6 mmHg; P=0.36). The subjective rating of the facility of drops instillation was significantly higher with the Eyedrop® applicator (VAS =7.6±1.6) than without it (VAS =6.2±1.8; P<0.01), with a higher frequency of positive device-related evaluations (VAS score >5) among participants without prior experience with eye drop instillation (78.6% [11/14]) versus those already experienced (66.7% [12/18]). No difference in the frequency of side effects or in the distribution pattern of fluorescein between eyes was observed (P≥0.63).ConclusionEyedrop® received a better subjective response regarding the ease of instillation of hypotensive eye drops compared to traditional instillation, especially in patients with no previous experience with eye drops. Using the device did not result in any loss of hypotensive effect or increase in the frequency of side effects.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Evaluation of the efficacy and safety of a new device for eye drops instillation in patients with glaucoma

Junqueira¹,

Lopes²,

Souza³

et al. 2015

OPTH

View full text Add to dashboard Cite

show abstract

“…This nearly 40 second difference seems to be due to differing instillation styles or dosages or difficulties instilling the drops accurately into the eyes. Recently, various devices have been developed to address different aspects of eyedrop placements, with which the patients struggle, and our developed system can contribute these efforts 23. A report has indicated that difficulty in instillation procedure leads to poor adherence 24.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Automatic Monitoring of Instillation Adherence Using Eye Dropper Bottle Sensor and Deep Learning in Patients With Glaucoma

Nishimura¹,

Tabuchi²,

Nakakura³

et al. 2019

Trans. Vis. Sci. Tech.

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Purpose We developed and evaluated an eye dropper bottle sensor system comprising motion sensor with automatic motion waveform analysis using deep learning (DL) to accurately measure adherence of patients with antiglaucoma ophthalmic solution therapy. Methods We enrolled 20 patients with open-angle glaucoma who were treated with either latanoprost ophthalmic solution 0.005% or latanoprost-timolol maleate fixed combination ophthalmic solution in both eyes. An eye dropper bottle sensor was installed at patients' homes, and they were asked to instill the medication and manually record each instillation time for 3 days. Waveform data were automatically collected from the eye dropper bottle sensor and judged as a complete instillation by the DL instillation assessment model. We compared the instillation times captured on the waveform data with those on each patient's record form. In addition, we also calculated instillation movement duration from Waveform data. Results The developed eye bottle sensor detected all 60 instillation events (100%). Mean difference between patient and eye bottle sensor recorded time was 1 ± 1.22 (range, 0–3) minutes. Additionally, mean instillation movement duration was 16.1 ± 14.4 (range, 4–43) seconds. Two-way ANOVA revealed a significant difference in instillation movement duration among patients ( P < 0.001) and across days ( P < 0.001). Conclusion The eye dropper bottle sensor system developed by us can be used for automatic monitoring of instillation adherence in patients with glaucoma. Translational Relevance We believe that our eye dropper bottle sensor system will accurately measure adherence of all glaucoma patients as well as help glaucoma treatment.

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“…A inclusão de filtros para radiação UV nos óculos é assim essencial. Ao longo do tempo, vários estudos têm sido efetuados sobre a qualidade da proteção fornecida por óculos de sol contra as radiações ultravioleta e visível a que o utilizador está submetido [1][2][3][4][5][6][7][8].…”

Section: Introductionunclassified

Proteção contra a radiação ultravioleta fornecida por óculos de sol

Peralta

2020

Rev. Bras. Ensino Fís.

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Resumo Ao comprar óculos de sol é importante garantir que estes oferecem uma proteção eficaz contra a radiação ultravioleta (UV). Embora invisível, este tipo de radiação pode causar sérios danos à retina. O uso de lentes sem proteção UV adequada pode revelar-se prejudicial, uma vez que a diminuição da luz visível leva a um aumento da pupila do olho. Neste trabalho propomos a construção de um dispositivo que permite testar a redução da intensidade luminosa introduzida pelas lentes coloridas de óculos. O sistema é baseado em LEDs coloridos e um fotossensor com amplificação integrada.

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Evaluation of the Xal-Ease™ latanoprost delivery system

Cited by 10 publications

References 16 publications

Evaluation of the efficacy and safety of a new device for eye drops instillation in patients with glaucoma

Evaluation of the efficacy and safety of a new device for eye drops instillation in patients with glaucoma

Evaluation of Automatic Monitoring of Instillation Adherence Using Eye Dropper Bottle Sensor and Deep Learning in Patients With Glaucoma

Proteção contra a radiação ultravioleta fornecida por óculos de sol

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