Evaluation of Therapeutic Efficacy of Vinpocetine in Adjuvant Induced Arthritis Model in Rats

Abstract

Introduction: Rheumatoid Arthritis (RA) is an incurable chronic inflammatory disorder. Indomethacin is used for symptomatic management of RA; its long term use is associated with potentially life-threatening deleterious side effects. Vinpocetine is an alkaloid extracted from the periwinkle plant used for treating cerebrovascular disorders with no significant side effects. Recent evidences demonstrate its anti-inflammatory properties.Objective: To evaluate the anti-inflammatory, analgesic and neuroprotective activities of vinpocetine against RA as well as the associated neurological disorders and to investigate its influence on the anti-inflammatory activity of indomethacin in rats. Methods:Complete Freund's adjuvant induced arthritic rats were treated for 3 weeks with indomethacin (1, 2 mg/ kg P.O.) and/or vinpocetine (20 mg/kg P.O.). Body weight, ankle diameter, arthritic score, serum tumor necrosis factor alpha (TNF-α) and interleukin one beta (IL-1β), tissue expression of nuclear factor kappa B (NF-κB) were determined and gait score were assessed. Brain monoamines levels and behavior in the swimming test were also measured. In addition, histopathological examinations of hind paw and brain tissues as well as X-ray examinations of the paw were performed.Results: Combination therapy of vinpocetine with indomethacin significantly improved analgesic and inflammatory parameters as compared to indomethacin alone. Vinpocetine alone decreased the inflammatory markers in the same extent as indomethacin. In some parameters, vinpocetine has equal effect as the combination therapy. It also decreased swimming time while increased direction score together with increased brain norepinepherine and serotonin as well as serum total anti-oxidant capacity (TAC) level. Histopathological and X-ray examinations supported these results.Conclusion: Vinpocetine has potent anti-arthritic, anti-inflammatory and anti-nociceptive effects. It also potentiates the anti-inflammatory action of indomethacin. It also improves RA associated depression. Thus, it can be used either alone or in combination with indomethacin to avoid or to decrease the serious side effects of indomethacin and to improve RA associated depression. Citation: Ali AA, El-Zaitony AS, Al-Haleem ENA (2016) Evaluation of Therapeutic Efficacy of Vinpocetine in Adjuvant Induced Arthritis Model in Rats. J Pain Manage Med 2: 115.

Evaluation of the possible therapeutic role of omega-3 on ankle joint and lung in a model of rheumatoid arthritis in rats: A histological and immunohistochemical study

“…In addition, it was demonstrated that in RA, macrophages, fibroblast-like synoviocytes and activated T cells produced pro-inflammatory mediators, as interleukin-1 beta (IL-1β) and TNF-α, which played key roles in the pathogenesis of RA [31] . These cytokines might be involved in promoting inflammation, synovial tissue hyperplasia and osteoclast differentiation [32] . Also, IL-1β and TNF-α might stimulate chondrocytes and osteoclasts to release the cartilage and bone-destroying metalloproteinases [33] .…”

An Integrative Transcriptomic Analysis of Systemic Juvenile Idiopathic Arthritis for Identifying Potential Genetic Markers and Drug Candidates

“…Vincamine (enrichment score = 0.53 and p = 4.21 × 10 −02 ) was previously shown to prevent inflammation induced by lipopolysaccharide in a human corneal epithelial cell line [ 51 ]. A synthetic derivative of vincamine was suggested to have potent anti-arthritic and anti-inflammatory effects in rat models [ 52 ]. The other drug candidates that were indirectly linked to rheumatic diseases were racecadotril (enrichment score = 0.67 and p = 2.47 × 10 −02 ) and streptozocin (enrichment score = 0.65 and p = 3.34 × 10 −02 ).…”

The role of Th1/Th2/Th17 cytokines and antioxidant defense system in mediating the effects of lemon and grapefruit peel hydroethanolic extracts on adjuvant-induced arthritis in rats

“…A change in rheumatoid indices as right hind paw circumference, paw volume, and paw thickness has been utilized for assessing the anti-inflammatory effects on RA (Ali et al, 2016;Chen et al, 2017;Eiseman et al, 1982). In the present investigation, these rheumatoid indices were measured to assess the anti-arthritic activity of lemon and grapefruit peel hydroethanolic extracts at the dose level of 100 mg/kg/bw in arthritic rats.…”