Evaluation of Therapeutic Efficacy of Different Treatment Modalities in Oral Submucous Fibrosis: A Comparative Study

Abstract

Aim: Aim of this study was to assess the efficiency of different treatment modalities for oral submucous fibrosis.Materials and methods: Sixty patients were included in the study, which was diagnosed as stage II oral submucous fibrosis (OSMF) based on habitual history and clinical findings. Three groups were made after randomization, i.e., group 1: capsule lycopene group, group 2: capsule lycopene and injection dexamethasone, group 3: injection dexamethasone and hyaluronidase group. Symptom severity was done by visual analog scale (VAS) scoring system viz burning sensation/pain in the patients; patient satisfaction was assessed. Vernier calipers were used to measure patients' maximum mouth opening at day 1, 1st month, 2nd month, 3rd month.

Drug treatment for oral submucous fibrosis: an update

“…Datarkar et al [ 18 ] showed that prednisolone mouthwash was superior to antioxidant capsules only in improving MMO, but was inferior to antioxidant capsules in relieving BS and ulcers. Systemic corticosteroids are rarely used in the treatment of OSF and usually administered as intrafocal injections or mouthwashes [ 41 ]. Overall, steroids can alleviate the signs and symptoms of OSF and can be used in combination with other medications as adjunctive therapy.…”

“…Exogenous enzyme hyaluronidase can target MMP-1 or MMP-2 to destroy abnormal fibrotic tissue, thereby alleviating or curing OSF [ 46 , 47 ]. Study of Beenakumary et al showed that hyaluronidase combination with dexamethasone injection was superior to lycopene in improving MMO [ 41 ]. Johny et al [ 34 ] showed that LycoRed along with hyaluronidase intralesional injection had 92.8% partial response and 7.2% complete response in improving BS.…”

Drug treatment for oral submucous fibrosis: a systematic review

“…Compared with control drugs (such as lycopene, aloe vera, and pentoxifylline), hyaluronic acid combined with steroids was equally effective in relieving burning and improving mouth opening in patients with OSF but superior to placebo. At the same time, owing to their side effects, systemic corticosteroids are rarely used in the treatment of OSF and usually administered as intrafocal injections or mouthwashes [14]. Overall, steroids can alleviate the signs and symptoms of OSF and can be used in combination with other medications as adjunctive therapy.…”