Evaluation of therapeutic potentials of plant extracts against poultry bacteria threatening public health

Abiala, Moses Akindele; Olayiwola, John Olusola; Babatunde, Oluwatoyin; Aiyelaagbe, Olapeju O.; Akinyemi, S. O. S.

doi:10.1186/s12906-016-1399-z

Cited by 23 publications

(22 citation statements)

References 38 publications

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“…These findings were close to that (20%) reported earlier in India [1]. Many studies showed different prevalence rates of P. aeruginosa isolates in broilers worldwide: in Iraq, a low rate of 6% was reported [33], while in Nigeria, a high rate of 75% was reported [34]. These differences in prevalence rates may reflect the considerable disparity in the sampling scheme, sample types, pseudomonas detection protocol, and geographic location.…”

Section: Discussionsupporting

confidence: 86%

Evaluation of the Synergistic Effect of Amikacin with Cefotaxime against Pseudomonas aeruginosa and Its Biofilm Genes Expression

El-Demerdash¹,

Bakry²

2020

Gene Expression and Phenotypic Traits

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A total of 100 broiler chickens were examined for the presence of Pseudomonas aeruginosa by standard microbiological techniques. Susceptibility pattern for amikacin and cefotaxime was performed by Kirby-Bauer and microdilution assays. Then, checkerboard titration in trays was applied and FIC was measured to identify the type of interaction between the two antibiotics. The ability of isolates to form in vitro biofilm was detected by two methods, one qualitative (CRA) and the other quantitative (MTP), followed by investigating the effect of each antibiotic alone and in combination on the expression of biofilm genes. The overall isolation percentage of P. aeruginosa was 21%. Resistance to each antibiotic was more than 50%; the range of cefotaxime MIC was 8-512 μg/ml, while amikacin MIC range was 1-64 μg/ml. The FIC index established a synergistic association between tested two drugs in 17 (81%) of isolates and the remaining represent partially synergism. The qualitative technique showed that only 66.6% of the isolates were considered biofilm producers, while the quantitative technique showed that 90.4% of the isolates were biofilm producers. Further to RT-PCR investigation, significant repression against biofilm-forming genes (filC, pelA, and pslA) was observed for the combination of antibiotics when compared with monotherapy.

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Section: Discussionsupporting

confidence: 86%

Evaluation of the Synergistic Effect of Amikacin with Cefotaxime against Pseudomonas aeruginosa and Its Biofilm Genes Expression

El-Demerdash¹,

Bakry²

2020

Gene Expression and Phenotypic Traits

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“…However, most vaccination programs are strongly biased toward the prevention of viral diseases. In recent times, more research has been emerging on the potential value of using plant extracts to control bacterial diseases in poultry ( 128 ).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance in Bacterial Poultry Pathogens: A Review

2017

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Antimicrobial resistance (AMR) is a global health threat, and antimicrobial usage and AMR in animal production is one of its contributing sources. Poultry is one of the most widespread types of meat consumed worldwide. Poultry flocks are often raised under intensive conditions using large amounts of antimicrobials to prevent and to treat disease, as well as for growth promotion. Antimicrobial resistant poultry pathogens may result in treatment failure, leading to economic losses, but also be a source of resistant bacteria/genes (including zoonotic bacteria) that may represent a risk to human health. Here we reviewed data on AMR in 12 poultry pathogens, including avian pathogenic Escherichia coli (APEC), Salmonella Pullorum/Gallinarum, Pasteurella multocida, Avibacterium paragallinarum, Gallibacterium anatis, Ornitobacterium rhinotracheale (ORT), Bordetella avium, Clostridium perfringens, Mycoplasma spp., Erysipelothrix rhusiopathiae, and Riemerella anatipestifer. A number of studies have demonstrated increases in resistance over time for S. Pullorum/Gallinarum, M. gallisepticum, and G. anatis. Among Enterobacteriaceae, APEC isolates displayed considerably higher levels of AMR compared with S. Pullorum/Gallinarum, with prevalence of resistance over >80% for ampicillin, amoxicillin, tetracycline across studies. Among the Gram-negative, non-Enterobacteriaceae pathogens, ORT had the highest levels of phenotypic resistance with median levels of AMR against co-trimoxazole, enrofloxacin, gentamicin, amoxicillin, and ceftiofur all exceeding 50%. In contrast, levels of resistance among P. multocida isolates were less than 20% for all antimicrobials. The study highlights considerable disparities in methodologies, as well as in criteria for phenotypic antimicrobial susceptibility testing and result interpretation. It is necessary to increase efforts to harmonize testing practices, and to promote free access to data on AMR in order to improve treatment guidelines as well as to monitor the evolution of AMR in poultry bacterial pathogens.

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“…It is in this perspective that the hydro-ethanolic extract of Canarium schweinfurthii has been explored for its antisalmonellal activity and its bioactive compounds. Several plants are traditionally used against human salmonellosis [41][42][43][44][45][46] and avian salmonellosis [24][25][26]47]. Plants with high anti-salmonellal potential that show promise for the control of avian salmonellosis include Aloe secundiflora [47], Thymus vulgaris [48], Curcuma longa and Scutellaria baicalensis [25] and Erica mannii [27].…”

Section: Discussionmentioning

confidence: 99%

“…The large majority of salmonellosis in humans is carried by foodstuffs; mainly those of avian origin [10,20,21], therefore controlling avian salmonellosis by using plant could significantly reduce the prevalence of human gastroenteritis [20]. Several studies have focused on medicinal plants as new control strategies for human salmonellosis [22,23] or avian salmonellosis [24][25][26][27][28]. But, to our knowledge, no phytomedicine has yet been formulated to control avian salmonellosis.…”

Section: Introductionmentioning

confidence: 99%

Isolation, characterization and in vitro anti-salmonellal activity of compounds from stem bark extract of Canarium schweinfurthii

Sokoudjou

Atolanı

Njateng

et al. 2020

BMC Complement Med Ther

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Background Bacteria belonging to the Salmonella genus are major concern for health, as they are widely reported in many cases of food poisoning. The use of antibiotics remains a main stream control strategy for avian salmonellosis as well as typhoid and paratyphoid fevers in humans. Due to the growing awareness about drug resistance and toxicities, the use of antibiotics is being discouraged in many countries whilst advocating potent benign alternatives such as phyto-based medicine. The objective of this work was to isolate, characterise the bioactive compounds of Canarium schweinfurthii; and evaluate their anti-salmonellal activity. Methods The hydro-ethanolic extract of Canarium schweinfurthii was fractionated and tested for their anti-salmonellal activity. The most active fractions (i.e. chloroform and ethyl acetate partition fractions) were then explored for their phytochemical constituents. Fractionation on normal phase silica gel column chromatography and size exclusion chromatography on Sephadex LH-20 led to the isolation of four compounds (maniladiol, scopoletin, ethyl gallate and gallic acid) reported for the first time in Canarium schweinfurthii. Results Result indicated that scopoletin and gallic acid had greater activity than the crude extracts and partition fractions. Among the isolated compounds, scopoletin showed the highest inhibitory activity with a MIC of 16 μg/ml against Salmonella Typhimurium and Salmonella Enteritidis. Conclusions The overall results of this study indicates that the hydro-ethanolic extract as well as some of isolated compounds have interesting anti-salmonellal activities that could be further explored for the development of potent therapy for salmonellosis. Furthermore, the study adds credence to the folkloric applications of the plant.

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Evaluation of therapeutic potentials of plant extracts against poultry bacteria threatening public health

Cited by 23 publications

References 38 publications

Evaluation of the Synergistic Effect of Amikacin with Cefotaxime against Pseudomonas aeruginosa and Its Biofilm Genes Expression

Evaluation of the Synergistic Effect of Amikacin with Cefotaxime against Pseudomonas aeruginosa and Its Biofilm Genes Expression

Antimicrobial Resistance in Bacterial Poultry Pathogens: A Review

Isolation, characterization and in vitro anti-salmonellal activity of compounds from stem bark extract of Canarium schweinfurthii

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