Evaluation of therapeutic substances employed for the relief of bronchospasm

Evaluation of Therapeutic Substances Employed for the Relief of Bronchospasm. Vi. Aminophylline 1

“…Such anti-asthmatic drugs as the sympathomimetic amines have a rapid, intense protecting action in minute doses, whereas the effect of aminophylline is milder and more prolonged and the dose employed is many times greater. In dosage and in the time sequence of its protecting action, aminophylline approaches more closely the antihistaminic drugs (blocking agents), data on which will be presented elsewhere - (13).…”

Handbook of respiration

“…Month [9][10][11][12] Reference : Krogman. W. M. , Tabulae Biologicae 20:669, 1941 (adapted from Scammon, R. E., Radiology 9:101 , 1927).…”

“…[l] Values for oxygenated blood are means of values in the literature, the 100% range being approximately ± 5 ml gas per 100 ml blood; other data are calculations based upon these means. [2][3][4][5][6][7][8][9][10][11] Major factors which influence CO^absorption include state of oxygenation, temperature, hemoglobin concentration, and alkali reserve. [1,[6][7][8][9][11][12][13]…”

“…In equations ('i)- (9), Va and VCO2 are under the same conditions and in the same units. However, the general condition for VcOj is at STPD and for Va at BTPS.…”

“…Death results in [8][9][10][11][12][13][14][15][16][17][18][19][20] minutes. Values are averages of 4 dogs for first five minutes of breathing time, and of 3 dogs thereafter.…”