Evaluation of Three Automated Nontreponemal Rapid Plasma Reagin (RPR) Tests for the Laboratory Diagnosis of Syphilis

Shukla, Mayur; Pereira, Lara; Gaynor, Anne; Sun, Yongcheng; Edwards, Daniel C.; Simmons, Tamara; Andrews, Chelsea; Park, Ina U.; Hong, Jaeyoung; Cao, Weiping; Kersh, Ellen N.; Fakile, Yetunde

doi:10.1128/jcm.00168-23

Cited by 6 publications

(1 citation statement)

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“…This breakthrough redefined the approach to syphilis treatment, shifting from toxic compounds to antibiotics [69]. The widespread use of penicillin led to a substantial decrease in syphilis cases, marking a significant improvement in syphilis control over the past five decades, especially when compared to the pre-penicillin era [70].…”

Section: Pharmacological Interventionsmentioning

confidence: 99%

Advancing Syphilis Research: Exploring New Frontiers in Immunology and Pharmacological Interventions

Fajemiroye,

Moreira,

Ito

et al. 2023

Venereology

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In recent years, the global resurgence of syphilis has posed significant challenges to public health. This sexually transmitted infection, caused by the bacterium Treponema pallidum, can have severe consequences if left untreated, including neurological and cardiovascular complications. Diagnosing syphilis is complex due to its diverse clinical presentations, necessitating a multifaceted approach, including serological, molecular, and direct techniques such as dark-field microscopy. Penicillin remains the primary and effective treatment, but emerging macrolide-resistant strains have spurred investigations into alternative antibiotics. Syphilis vaccine development faces unique hurdles, yet promising strategies are under investigation. Targeted prevention strategies focus on high-risk populations such as men who have sex with men, pregnant women, and individuals with multiple sexual partners. The integration of syphilis services into primary healthcare enhances accessibility, early detection, and treatment. Innovative point-of-care diagnostics offer rapid, sensitive testing, while ongoing vaccine research holds the potential for long-term prevention. Addressing the global burden of syphilis requires a multifaceted approach, encompassing immunological advancements, innovative diagnostics, targeted prevention, and primary healthcare integration. Collaborative efforts between governments, healthcare systems, researchers, and communities are essential to effectively combat syphilis, striving toward a syphilis-free future that promotes better sexual health and overall well-being.

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Section: Pharmacological Interventionsmentioning

confidence: 99%