Evaluation of thyroid function tests of acne vulgaris patients treated with systemic isotretinoin

Yıldırım, Neslihan; Doğan, Sibel; Atakan, Nilgün

doi:10.1080/09546634.2016.1214232

Cited by 6 publications

(8 citation statements)

References 14 publications

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“…However, a significant decrease in T4 and T3 levels associated with a significant increase in TSH levels (but still within normal range) during isotretinoin treatment for acne was observed 12 . The results of the present study confirm the findings of Yıldırım et al…”

Section: Discussionsupporting

confidence: 91%

“…Previous studies showed that isotretinoin might affect thyroid functions in different ways 9‐12 . The present study has been an attempt to clarify the patterns of the possible changes in the levels of thyroid hormones (free thyroxin “fT4”, free triiodothyronine “fT3”), and thyroid‐stimulating hormone “TSH” during isotretinoin therapy for patients suffering from severe acne vulgaris.…”

Section: Introductionmentioning

confidence: 96%

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Patterns of thyroid dysfunctions in adolescent patients suffering from severe acne during isotretinoin treatment

Hareedy

Mahmoud

Tawfik

2021

Clin Exp Pharma Physio

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Although oral isotretinoin has been widely used as a basic treatment of acne in adolescents, several studies have noted some alterations in thyroid functions during oral isotretinoin therapy. Therefore, the present study aims at evaluating the possible changes in thyroid‐stimulating hormone (TSH), free thyroxin (fT4) and free triiodothyronine (fT3) levels during isotretinoin treatment and analyzing the possible factors which may contribute to such changes. In the present study, 47 patients received (0.5 mg/kg oral isotretinoin) for treatment of severe acne. TSH, fT4 and fT3 were measured at baseline, after 3 and 6 months. ANOVA tests were used for statistical analyses. The levels of fT4 and fT3 decreased significantly during isotretinoin treatment (from 0.85 ± 0.04 and 3.1 ± 0.26 at baseline to 0.81 ± 0.023 and 2.76 ± 0.2 after 6 months, respectively). The decrease was accompanied by significant elevation of TSH (0.66 ± 0.05 at baseline to 0.695 ± 0.05 after 6 months). The duration of therapy (but not the dose) has significantly affected all the hormonal changes. Previous incomplete or intermittent isotretinoin treatment had significantly influenced the changes in fT4 only, while gender affected the changes of TSH. Isotretinoin treatment can decrease fT4, fT3 and increase TSH. The pattern of these changes was affected by gender and previous isotretinoin therapy. Different doses of isotretinoin did not affect the hormonal changes, but the duration has been the major influencing factor.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 96%

Patterns of thyroid dysfunctions in adolescent patients suffering from severe acne during isotretinoin treatment

Hareedy

Mahmoud

Tawfik

2021

Clin Exp Pharma Physio

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“…In studies focusing on thyroid hormone levels following isotretinoin treatment, it has been noted that, by the end of the treatment course, patient's TSH levels are elevated, while free T3 and T4 levels are decreased [3, 12]. It is possible that alternations of TSH levels could be due to isotretinoin effects on nuclear retinoid X receptors (RXR), which dimerizes with nuclear retinoid acid receptors (RAR) and nuclear thyroid receptors [2, 13].…”

Section: Discussionmentioning

confidence: 99%

Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients

Nugroho

Schweiger

2017

Case Reports in Pediatrics

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Introduction. Isotretinoin is commonly used to treat cystic acne. Definitive mechanisms of action for isotretinoin are not known though despite many side effects having been documented. Various case reports have noted autoimmune diseases succeeding isotretinoin treatment. Case Report. A 16-year-old female presents with symptoms of tremors, lack of focus, sleeplessness, emotional liability, bulging eyes, loose stools, heat intolerance, and missed menstrual periods. Symptoms manifested shortly after the patient finished a course of oral isotretinoin treatment for acne. Physical exam showed resting tremors, bilateral proptosis, hyperactivity, and rapid speech. A diagnosis of Graves' Disease was made by correlating symptoms, physical exam findings, ultrasound, and positive family history of autoimmune thyroid disease. Conclusion. Emergence of autoimmune thyroid diseases depends upon genetic predisposition and environmental triggers. Mechanism of action for isotretinoin is not known but the drug may play a role in triggering autoimmunity in genetically susceptible individuals.

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“…[ 1 ] Yıldırım et al . [ 2 ] evaluated thyroid function tests in 51 patients treated with 0.5–1 mg/kg/day oral isotretinoin. They reported a patient whose TSH level got lower than normal limits at 3 rd month and returned to normal levels at 6 th month.…”

mentioning

confidence: 99%

“…They also reported three patients with slightly elevated levels of free T3 during the treatment. [ 2 ]…”

mentioning

confidence: 99%

Systemic retinoids and thyrotoxicosis in (Multi) nodular goiter: Side effect or coincidence?

Aksoy

2018

Indian J Dermatol

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Evaluation of thyroid function tests of acne vulgaris patients treated with systemic isotretinoin

Abstract: Systemic isotretinoin therapy causes significant alterations in sTFTs. Dose dependent or long-term effects of systemic isotretinoin on sTFTs needs further evaluation.

Cited by 6 publications

References 14 publications

Patterns of thyroid dysfunctions in adolescent patients suffering from severe acne during isotretinoin treatment

Patterns of thyroid dysfunctions in adolescent patients suffering from severe acne during isotretinoin treatment

Isotretinoin as a Possible Environmental Trigger to Autoimmunity in Genetically Susceptible Patients

Systemic retinoids and thyrotoxicosis in (Multi) nodular goiter: Side effect or coincidence?

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