Evaluation of Thyroid Hormone Changes in Non-Pregnant, Normotensive Pregnant and Pregnancy with Preeclampsia

Das, Swapan K.

doi:10.9790/0853-1161618

Cited by 2 publications

(3 citation statements)

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“…The results of this study showed that the higher TSH mean level in preeclamptic patients, which is consistent with other studies [ 35 , 64 , 82 ]. Even though placental function abnormalities can interfere with estrogen production, leading to decrease of TBG levels and it can be a reason for elevated TSH secretion by anterior pituitary [ 59 , 61 ] but in the some studies, TSH level in preeclamptic women was not higher than normal pregnant women [ 3 , 41 ].…”

Section: Discussionsupporting

confidence: 93%

“…In another study, TSH is correlated positively with systolic blood pressure in preeclampsia [ 31 ] but this relationship did not find in this metanalysis. The differences observed in researches could be as a result of differences in the race, diets, and geographical locations of participants [ 29 ].In general, the results of current meta-analysis showed that an increase serum TSH with a meaningless difference in FT4 in preeclamptic women is called subclinical hypothyroidism [ 5 ]; this finding is supported by previous studies [ 42 , 44 , 64 ].…”

Section: Discussionsupporting

confidence: 73%

“…The hypothesis appropriate to these conditions is that the conversion of T4 to T3 is impaired in the liver, which could be the reason for the low level of FT3 in women with preeclampsia [ 30 ]. No difference in FT3 between the two groups was observed in other studies [ 30 , 64 , 82 ]. The findings of present study showed lower mean FT4 level in preeclamptic patients is similar to the results of other studies [ 30 , 38 , 41 ] while finding of some investigations showed a higher mean FT4 level in preeclampsia [ 14 , 23 ].…”

Section: Discussionmentioning

confidence: 47%

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Association of thyroid function test abnormalities with preeclampsia: a systematic review and meta-analysis

et al. 2022

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Background Preeclampsia is a life-threatening disorder during pregnancy and postpartum periods. Preeclampsia can affect the activity of many organs. It is very important because if this disorder is associated with changes in thyroid function, it can affect the results of maternal and fetal tests. Accordingly, the aim of this meta-analysis study was to assess the abnormalities in thyroid function tests in preeclampsia. Methods Studies were selected through a systematic search of the MEDLINE/PubMed, Scopus, Web of Science Core Collection, and Google Scholar databases in 31st August 2021. Also, reference lists of review articles and relevant studies were manual-searched to identify other potentially eligible studies. English studies that compared TSH, T4 and T3 of normal pregnant with preeclamptic women (Known to be normotensive before pregnancy; gestational age 20 week or more; singleton pregnancy; no previous history of thyroid dysfunction) were screened. Data sets were screened for eligibility by two independent reviewers. Articles were assessed by the Newcastle–Ottawa Scale. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used for quality assessment of evidence on outcome levels. Results After reviewing 886 published studies, 63 observational studies were selected and used for this meta-analysis. The study population included 21,528 pregnant women. The findings revealed that TSH (SMD = 1.70, 95%CI: 1.39 to 2.02; p < 0.001) was significantly higher in preeclamptic women. TT4 (SMD = -0.82, 95%CI: -1.16, -0.49; p < 0.001), TT3 (SMD = -0.88, 95%CI: -1.36 to -0.41; p < 0.001) and FT3 (SMD = -0.59, 95%CI: -0.91 to -0.27; p < 0.001) were less in preeclamptic women. There was no statistically significant difference in FT4 between two groups (SMD = 0.002, 95%CI: -0.27 to 0.27; p = .990). The results of publication bias and sensitivity analysis confirmed the reliability and stability of this meta-analysis. The quality of evidence was regarded as moderate, low, and very low for these risk factors according to the GRADE approach. Conclusions Findings of this meta-analysis indicated preeclamptic women were more at risk of changes in thyroid function tests. In order to prevent thyroid disorders, it is recommended that thyroid function tests be performed in women with pre-eclampsia.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 47%

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Association of thyroid function test abnormalities with preeclampsia: a systematic review and meta-analysis

et al. 2022

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Study of Thyroid Profile, Uric Acid, Creatinine and Lipid Profile in Pre-Eclampsia Patient

Dehariya¹,

Jaiswal²,

UPADHYAY³

et al. 2023

Asian J Pharm Clin Res

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Objectives: (1) To evaluate and compare the thyroid profile and lipid profile in preeclampsia in a normotensive pregnant female in the third trimester of pregnancy. (2) To estimate and compare serum uric acid and serum creatinine in preeclampsia in normotensive pregnant females. Methods: In the present study, 154 patients, of which 79 preeclampsia (cases) and 75 (controls), were selected randomly and matched with their gestational age in patients who attended an ANC clinic at the Department of Obstetrics and Gynecology, NSCB Medical College, Jabalpur, from March 2016 to August 2017. All patients were evaluated for their lipid profile, thyroid profile, serum uric acid, and serum creatinine. The study includes patient’s specific detailed clinical history, physical examination findings, and a report of relevant investigations recorded from the patient who presented with pre-eclampsia and normotensive pregnant female attending the ANC Clinic of N.S.C.B. Medical College, Jabalpur. Results: The most common age group for preeclampsia was 20–24 years. Preeclampsia was most common in the nullipara as compared to the multipara. Pre-eclampsia cases commonly occur in low-socioeconomic and rural areas. In this study, pre-eclamptic women showed higher serum concentrations of total cholesterol (221.60±22.55), low density lipoprotein (LDL) (134.44±16.96), Very LDL (48.48±6.88) and Triglyceride (243.50±32.33) when compared to normotensive women, which was statistically significant. In this study, a statistically significant decrease in HDLC (34.55±5.37) was observed in pre-eclamptic women. An increase in serum creatinine was observed in women with pre-eclampsia. The mean serum creatinine level was (1.21±0.47). Conclusion: Our study concludes that nulliparous and low-socio-economic women had a higher risk of pre-eclampsia. Maternal age between 20 and 24 years are more prone to develop pre-eclampsia. Serum uric acid levels are significantly higher in pre-eclampsia patients and could be a useful indicator of maternal and fetal complications in hypertensive patients.

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Evaluation of Thyroid Hormone Changes in Non-Pregnant, Normotensive Pregnant and Pregnancy with Preeclampsia

Cited by 2 publications

References 8 publications

Association of thyroid function test abnormalities with preeclampsia: a systematic review and meta-analysis

Association of thyroid function test abnormalities with preeclampsia: a systematic review and meta-analysis

Study of Thyroid Profile, Uric Acid, Creatinine and Lipid Profile in Pre-Eclampsia Patient

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