Evaluation of Thyroid Hormones and Some Biochemical Variables in Patients with Chronic Kidney Disease

Salih, Sama S.; Yenzeel, Jabbar H.; AL-Sa’ady, Ali J. R.

doi:10.24996/ijs.2020.61.5.6

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…In Park et al study including the serum metabolites, they found that serum uric acid in was not significantly differing between families with stone history than those without stone family history 54 . The risk of urolithiasis had been found to increase in gout patients suffering from serum uric acid and calcium high levels as a consequence of thyroid hormone dysregulation 55 . In this study, the uric acid concentration was not significantly differed between the two groups may be related to the normal function of the thyroid hormones that maintain normal calcium levels in the blood.…”

Section: Kidney Functions Testssupporting

confidence: 86%

GRHPR gene variations in Iraqi patients infected with calcium oxalate kidney stones

Alzubaidy,

Al Obaidy

2024

Baghdad Sci.J

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The alterations in glyoxylate reductase and hydroxy-pyruvate reductase concentrations in the sera and the genetic alterations associated with calcium oxalate kidney stones in Iraqi patients were not studied previously so this study aimed to focus on these points. This study included 80 subjects; they were 50 patients with calcium oxalate stones compared to 30 apparently healthy controls. Biochemical investigations for kidney functions (creatinine, urea, and uric acid), were performed on the sera of both groups. Also, complete blood count, random blood sugar, and blood group tests. Furthermore, urine had been collected for General Urine Examination to visualize oxalate crystals in the urine of the patient. Also, the GRHPR enzyme concentration was measured by ELISA for both groups. The DNA was isolated from whole blood and the target DNA was amplified by PCR then the pathogenic mutations at c.295C>T (rs119490108), c.165G>A (rs180177314) and c.904C>T (p. Arg302Cys) rs180177322 were investigated by direct sequencing of the product, and then the results were analyzed. This study found that the concentration of the enzyme in the controls (4.78 ± 1.06 mg/dl) was significantly higher than its concentration in the patients (0.411 ± 0.02mg/dl). The pathogenic mutations were not found in both studied groups, but other positions were found polymorphic; at exon 4 the rs2768659 (A>G), rs1294628807 (G>A) and rs2736664 (C>T), at exon 6: c.579A>G (p. Ala193=) rs309458 and c.494-68A>G rs309459 and at exon 9 c.*146A>G rs1057507. In conclusion, this study found that calcium oxalate stones were associated with decrease GRHPR enzyme concentration in the patients compared to the control group which may be caused by mutations or epigenetics masking of the gene expression.

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Section: Kidney Functions Testssupporting

confidence: 86%

GRHPR gene variations in Iraqi patients infected with calcium oxalate kidney stones

Alzubaidy,

Al Obaidy

2024

Baghdad Sci.J

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“…According to the Kidney Disease Outcomes Quality Initiative (K/DOQI) CKD is defined as renal damage or when glomerular filtration rate (GFR) falls below 60 ml/min/1.73m 2 that lasts longer than three months [4]. CKD is split into five degrees depending on GFR level [5]. It has been observed that 10-15% of people in the world have CKD that increases with aging [6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Lipid Profile and Renal Function Levels in Iraqi Patients with Chronic Kidney Disease (CKD)

Lateef,

Alkubaisi,

AL-Hitti

et al. 2024

Iraqi Journal of Science

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Chronic Kidney Disease (CKD) has been raised as a public health state worldwide and is associated with increased cardiovascular morbidity and mortality. The aim of the study was to assess serum lipid profile levels, renal function and glucose in CKD patients undergoing hemodialysis. A total of 50 patients (23 males and 27 females) with CKD attending the hemodialysis at Kidney Unit in Al-Ramadi Teaching Hospital, Anbar Iraq and of ages ranging between 20 -85 years, were sustained for this research. The patients were classified into three categories with their mean age of 65.71±1.98 years. Eleven healthy adults were also recruited in this study with mean age of 37.00±15.56 years as control group. The study included measuring biochemical markers such as glucose, total cholesterol(TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein (VLDL) , creatinine and urea by using automated chemistry analyzer by Abbott/USA. The outcomes of this study showed that the urea and creatinine levels increased significantly, whereas HDL-C level significantly decreased in the patients as compared with control group. However, TC and LDL-C showed slightly lower levels which were within the normal limits in the control group. While TG, VLDL and glucose levels showed non-significant changes in CKD patients as compared with control (P ≤ 0.05). In addition, all parameters revealed no significant changes in males as compared with females group (P ≤ 0.05). Depending on age, only creatinine level showed significant change in 20-40 years age group as compared with 61-85years age group (p <0.05). Finally, abnormal lipid metabolism may probably be an independent risk factor for the progression of renal disease.

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Chronic Kidney Disease affects Thyroid Hormones

Mohammed Jadaan,

L. Al-Hayali

2024

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Kidney disease is one of the causes of death in many countries around the world. This study found that chronic kidney disease affects thyroid hormone formation, release, and storage. The results show a decrease in T3 and T4 thyroid hormones and an increase in TSH hormone in both sexes and people of different ages. The research aims to study the effect of chronic kidney disease on the thyroid gland’s activity and its deficiency’s effect on health ailments. Results showed a significant decrease in T3 concentration in patients at the probability level (p ≤ 0.05) (0.8±0.1) compared with the control group (1.0±0.1). Additionally, a significant decrease in T4 concentration at the probability level (p ≤ 0.05), (6.8±1.5) compared with the control group (8.7±0.9) and a significant increase in TSH concentration at the probability level (p ≤ 0.05), (4.8±0.6) compared with the control group (1.2±0.5). The CDK affects thyroid hormones; low T3 and T4 are the most common thyroid dysfunction. High TSH, enlarged thyroid gland, hypothyroidism, thyroid dysfunction. Keywords: CKD, Thyroid Hormones, Thyroid dysfunction.

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Evaluation of Thyroid Hormones and Some Biochemical Variables in Patients with Chronic Kidney Disease

Cited by 3 publications

References 23 publications

GRHPR gene variations in Iraqi patients infected with calcium oxalate kidney stones

GRHPR gene variations in Iraqi patients infected with calcium oxalate kidney stones

Evaluation of Serum Lipid Profile and Renal Function Levels in Iraqi Patients with Chronic Kidney Disease (CKD)

Chronic Kidney Disease affects Thyroid Hormones

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