Evaluation of Thyroid Nodule Malignant Neoplasms and Obesity Among Children and Young Adults

Ortega, Carlos A.; Gallant, Jean‐Nicolas; Chen, Sheau-Chiann; Ye, Fei; Wang, Huiying; Belcher, Ryan; Weiss, Vivian L.

doi:10.1001/jamanetworkopen.2021.16369

Cited by 15 publications

(15 citation statements)

References 6 publications

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“…This study is limited by its retrospective design and by unavailable data for some characteristics potentially associated with BMI, such as socioeconomic status and missing race and ethnicity for some patients; however, these factors were not associated with thyroid cancer in a previous study. 4 Findings of this cross-sectional study suggest that elevated BMI is not an independent risk factor for thyroid cancer in children with thyroid nodules. Routine thyroid examination is important in children, and any nodules detected should be evaluated based on the established risk factors described in current consensus guidelines.…”

Section: Association Between Body Mass Index and Thyroid Cancer In Ch...mentioning

confidence: 70%

“…2 The concurrent increase in childhood obesity and the association of obesity with thyroid cancer in adults 3 have prompted the hypothesis that obesity may be associated with an increased risk for thyroid cancer in children. Initial data supported this hypothesis, 4 and we sought to verify the association of obesity with thyroid cancer in a large cohort of children with thyroid nodules.…”

Section: Association Between Body Mass Index and Thyroid Cancer In Ch...mentioning

confidence: 99%

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Association Between Body Mass Index and Thyroid Cancer in Children With Thyroid Nodules

Ivanova

Cherella

Modi

et al. 2022

JAMA Otolaryngol Head Neck Surg

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bers of visits in 2018 and 2019. In Israel, virtual visits to community physicians by telephone became available during the COVID-19 pandemic. Because SSNHL is abrupt and substantially impairs the conduct of normal life, it is less likely that patients ignore the symptoms when there is immediate availability of health care services.Another explanation for these findings might be related to the substantial decrease in the occurrence of viral respiratory infections during the COVID-19 pandemic. 5 The Israel Center of Disease Control reported that influenza was not detected in all sentinel clinics between March and December 19, 2020. This lack of cases was most likely associated with social distancing, lockdown, and the use of masks. A possible association between infectious diseases and SSNHL might be supported by the observation of a time-clustered presentation of SSNHL, suggesting an environmental or infectious cause. 6 Although an attractive theory, if this were true, one would have expected that the occurrence of SSNHL would have remained low for the entire pandemic period because social distancing and face masks continued to be implemented, although to lesser extent later in 2020. The present study relied on data originally collected for administrative and clinical management and not specifically for the current study; thus, a possible limitation may be related to the quality of the data. In addition, International Classification of Diseases, Ninth Revision codes include only diagnosis of sensorineural hearing loss with no specific codes for SSNHL. However, to identify patients with SSNHL, our search included new diagnosis of hearing loss with a concurrent prednisone treatment, which is the standard of care for this condition. Therefore, the study did not include patients with SSNHL who were treated with intratympanic steroid injection as primary treatment in either 2020 or 2018 and 2019.

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Section: Association Between Body Mass Index and Thyroid Cancer In Ch...mentioning

confidence: 70%

Section: Association Between Body Mass Index and Thyroid Cancer In Ch...mentioning

confidence: 99%

Association Between Body Mass Index and Thyroid Cancer in Children With Thyroid Nodules

Ivanova

Cherella

Modi

et al. 2022

JAMA Otolaryngol Head Neck Surg

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“…У дітей перехресне дослідження виявило, що підвищені рівні загального або абдомінального ОЖ, виміряні за допомогою ІМТ, площі поверхні тіла та співвідношення обводу талії та стегон, були пов'язані зі значним підвищенням ризику розвитку вузлів ЩЗ, особливо множинних вузлів у дівчаток і поодиноких вузлів у хлопчиків [123]. Cеред пацієнтів віком до 21 року виявлено значущу різницю за медіаною показника ІМТ z при доброякісних та злоякісних вузлах, а збільшення ІМТ z було суттєво та незалежно пов'язане з ймовірністю злоякісних новоутворень у вузлах [87]. Автори цього дослідження вважають, що показник ІМТ z слід розглядати як клінічний чинник ризику при прийнятті рішення про операцію з приводу вузла ЩЗ у пацієнтів молодшого віку.…”

Section: ожирінняunclassified

“…Поширеність МФ ПРЩЗ становить від 18,6 до 45,0 % [22,23,43,61,86,87,104,10,115]. За даними кількох досліджень, частота МФ папілярної мікрокарциноми становила 26,9 -54,9 % [35,98,100].…”

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Multifocal papillary thyroid cancer in children and adults. Lecture

Tovkai¹,

Palamarchuk²,

Hryshchenko³

et al. 2022

CE&ES

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Thyroid cancer is the 9th most common cancer in the world. Thus, in the year 2020, 586.000 cases of thyroid cancer were registered worldwide. The incidence rate among women is 10.1 per 100 thousand population, and among men — 3.1 per 100 thousand population. In Ukraine, in 2019, the standardized rate of incidence of thyroid cancer (world standard) was 6.9 per 100.000 population (2.8 among men, 10.5 among women). In the structure of the incidence of malignant neoplasms of the cervical spine, thyroid cancer ranks first place among women aged 18 — 29 (19.9 %), fourth among both men aged 18 — 29 (8.3 %, and women aged 30 — 54 (8.1 %). Over the past 40 years, increased incidence of thyroid cancer (in particular, papillary thyroid cancer) is observed in most countries, which can be explained by various factors, for example, overdiagnosis, a change in the prevalence of modified risk factors. In Ukraine, in the period from 1989 to 2012, the rate of incidence of papillary thyroid cancer among men increased by 115 %, among women — by 137 %, the annual increase in incidence of papillary thyroid cancer for men and women was 5 and 6 %, respectively. Multifocality in papillary thyroid cancer is a characteristic feature that is much more common in pediatric patients than in adults, but the number of studies in children is limited, which is associated with a lower prevalence of the disease in children. The results of investigations on the multifocality predictors and its role in influencing relapse, persistence, and survival in patients with papillary thyroid cancer are conflicting in both adults and pediatric population. Among the risk factors of multifocality, a smaller number of controversies concerns the links of metastasis in the lymphatic nodes, radiation in the anamnesis, childhood age, and for bilaterality — multifocality of the primary lobe and the presence of contralateral benign nodes (in adults). Other factors as predictors of multifocality have controversial significance and deserve attention in further research. The identification of reliable predictors of multifocality, especially with the help of preoperative data analysis, as well as multifocality risk stratification will facilitate the complex decision‑making process for the correct treatment tactics of children and adults with papillary thyroid cancer.

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“…The World Health Organization (WHO) indicates that BMI and waist-hip ratio (WHR) are simple methods to identify individuals at increased risk for obesity-related diseases, which include a variety of neoplasm types [30][31][32][33]. Obesity has been associated with a state of chronic systemic inflammation, increased serum levels of insulinlike growth factor (IGF-1), and higher levels of estrogens [34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Head circumference and anthropometric changes and their relation to plexiform and skin neurofibromas in sporadic and familial neurofibromatosis 1 Brazilian adults: a cross-sectional study

Basto

Vieira

Andrade-Losso

et al. 2022

Orphanet J Rare Dis

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Background Neurofibromatosis 1 (NF1) is a common autosomal dominant syndrome with complete penetrance and highly variable expressivity. The cutaneous neurofibroma (Cnf) and plexiform neurofibroma (Pnf), café-au-lait spots, and freckle-like lesions are common in NF1, but many other manifestations can occur. We aimed to evaluate head circumference, height, weight, body mass index (BMI), head circumference-to-height ratio (HCHR) and waist–hip ratio (WHR) in adult NF1 Brazilian individuals versus a paired control group and investigate their correlation with the presence of clinically visible Pnfs, and number of “skin neurofibromas” (Snf), which include both cutaneous and subcutaneous neurofibromas. Methods A case–control study was conducted with 168 individuals, 84 with NF1 and 84 without NF1, paired by sex and age. Head circumference and anthropometric measurements, Snf quantification, evaluation of clinically visible Pnf and familial inheritance were accessed. Results Prevalence of macrocephaly was significantly higher in NF1 women. Height and weight were significantly lower in both males and females with NF1. HCHR was higher in the NF1 group than in the control group for both sexes. BMI was significantly lower in men with NF1. Waist and hip circumferences were significantly reduced in NF compared with the controls, but the mean WHR was significantly lower only in NF1 women. No correlation was found between the Snf and head circumference and anthropometric measurements, sex or family history. The presence and larger size of clinically visible plexiform neurofibromas were associated with normal stature (p = 0.037 and p = 0.003, respectively). Conclusions NF1 individuals have increased prevalence of macrocephaly, short stature, low BMI, and reduced abdominal fat. There is no relation between head circumference and anthropometric data with family history, or neurofibromas.

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Evaluation of Thyroid Nodule Malignant Neoplasms and Obesity Among Children and Young Adults

Cited by 15 publications

References 6 publications

Association Between Body Mass Index and Thyroid Cancer in Children With Thyroid Nodules

Association Between Body Mass Index and Thyroid Cancer in Children With Thyroid Nodules

Multifocal papillary thyroid cancer in children and adults. Lecture

Head circumference and anthropometric changes and their relation to plexiform and skin neurofibromas in sporadic and familial neurofibromatosis 1 Brazilian adults: a cross-sectional study

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