Evaluation of thyroid nodules with technetium‐99m MIBI and technetium‐99m pertechnetate

Abstract

In combination with FNA and three-phase pertechnetate scan, MIBI could be helpful in preoperative assessment of thyroid nodules. Intense MIBI activity increases the probability of thyroid cancer, whereas reduced activity drastically decreases the probability of malignancy.

Quantitative Analysis of Thyroid Blood Flow and Static Imaging in the Differential Diagnosis of Thyroid Nodules

“…Since first reported in 1987, 99m Tc-MIBI imaging has been increasingly used in the diagnosis of thyroid cancer due to its low radiation exposure and convenience of use (Sathekge et al, 2001). However, the reported performances of 99m Tc-MIBI imaging in the diagnosis of thyroid cancer were conflicting.…”

“…However, the specificity of such exam is low, therefore the use of radioisotope imaging has significantly declined (Marc, 2008). To further improve the accuracy, some researchers tried to combine the imaging of thyroid pro-tumor and thyroid gland to differentiate the benign and malignant thyroid nodules (Sathekge et al, 2001), which were unfortunately shown to be ineffective and only had very limited clinical value. The aim of this study is to use the combined quantitative analysis of both thyroid blood flow imaging and static imaging data to differentiate benign and malignant thyroid nodules, which may provide valuable information for the determination of treatment plan, surgical approach and prognosis.…”

Diagnostic Accuracy of Elastography and Scintigraphic Imaging After Thermal Microwave Ablation of Thyroid Nodules

“…Since "cold nodules" do not show any uptake of 99 m Tc-pertechnetate, 99 m Tc-MIBI has to be used as an alternative tracer to provide a comparison of uptake in "cold" nodules prior to and after microwave ablation. Previous studies have demonstrated the high potential of MIBI in detecting malignant thyroid nodules with high sensitivity, especially when combined with fine-needle aspiration cytology [24]. However, the uptake of 99 m Tc-MIBI is not only present in nodules of suspected malignancy, but also in benign cold nodules.…”

Cost-effectiveness of 99mTc-MIBI in the evaluation of thyroid nodules for malignancy: a new lease of life for an old radiopharmaceutical?

“…MIBI was first described in the 1980s [1,2]. Originally developed for myocardial perfusion scintigraphy for the detection and localization of coronary artery disease, it went on to eventually achieve registration not only for this indication, but also for the assessment of global ventricular function, scintimammography for the detection of suspected breast cancer when mammography is equivocal, inadequate or indeterminate, and localization of hyperfunctioning parathyroid tissue in patients with recurrent or persistent hyperparathyroidism, both primary and secondary, and in patients with primary hyperparathyroidism scheduled to undergo initial surgery of the parathyroid glands [3].However, for many years it has been known that MIBI scintigraphy can also be used in the diagnostic work-up of scintigraphically cold and therefore suspicious thyroid nodules in combination with fine needle biopsy (FNB) [4][5][6][7][8][9][10][11][12] Tc-pertechnetate thyroid scintigraphy MIBI scintigraphy can achieve a very high negative predictive value ranging from 88 % to 100 % with a mean of 97 %. Furthermore, the sensitivity of MIBI scintigraphy is similarly good with an aggregate value of 96 %.…”

“…However, for many years it has been known that MIBI scintigraphy can also be used in the diagnostic work-up of scintigraphically cold and therefore suspicious thyroid nodules in combination with fine needle biopsy (FNB) [4][5][6][7][8][9][10][11][12] Tc-pertechnetate thyroid scintigraphy MIBI scintigraphy can achieve a very high negative predictive value ranging from 88 % to 100 % with a mean of 97 %. Furthermore, the sensitivity of MIBI scintigraphy is similarly good with an aggregate value of 96 %.…”