Evaluation of total oxidative status and total antioxidant capacity in patients with endemic fluorosis

Abstract

The objective of the present study was to determine the plasma total oxidative status (TOS) and total antioxidant capacity (TAC) in patients with endemic fluorosis. A total of 79 (35 males and 44 females; mean age 44.0 ± 11.9 years) patients with endemic fluorosis and 55 (23 males and 32 females; mean age 48.3 ± 8.5 years) age-, sex- and body mass index-matched healthy controls were included in this study. The urine fluoride levels and plasma TOS and TAC levels were measured. The urine fluoride levels of fluorosis patients were significantly higher than control subjects as expected (1.91 ± 0.15 vs. 0.49 ± 0.13 mg/L, respectively; p < 0.001). TOS was significantly higher in fluorosis group than in control group (17.55 ± 3.82 vs. 15.06 ± 4.31 μmol H(2)O(2) Eq/L, respectively; p = 0.001). TAC was significantly lower in fluorosis group than in control group (1.60 ± 0.36 vs. 1.82 ± 0.51 mmol Trolox Eq/L, respectively; p = 0.004). Oxidative stress index (OSI) was significantly higher in fluorosis group than in control group (11.5 ± 3.8 vs. 8.8 ± 3.7, respectively; p < 0.001). Correlation analysis in all the groups indicated that TAC was negatively correlated with urine fluoride (r = -0.25, p = 0.003), TOS was positively correlated with urine fluoride (r = 0.34, p < 0.001) and OSI was positively correlated with urine fluoride (r = 0.36, p < 0.001). The results of our study demonstrate that oxidative stress plays an important role in the pathogenesis of the endemic fluorosis.

ClC-7/Ostm1 contribute to the ability of tea polyphenols to maintain bone homeostasis in C57BL/6 mice, protecting against fluorosis

“…(A) Representative images of each classification. Dental fluorosis in mice was classified by the modified Dean index (19,20) into 4 parts. Normal, the surface is smooth, glossy and usually a faint yellow color and is translucent; mild, the surface is smooth, glossy and usually a faint yellow color and is translucent; moderate, the white opaque areas in the enamel of the teeth are more extensive; severe, teeth often present a chalk-like appearance and fluorosed enamel with discrete or confluent pitting.…”

“…Thus, it is worthy to explore whether some ingredients in brick tea can antagonize the adverse effects of fluoride. It is proposed that oxidative stress plays a critical role in the pathogenesis of fluorosis (19,20). Tea polyphenols (TPs), the most bio-active ingredient in brick tea (21), have received considerable attention due to ther antioxidant effects and they have been shown to exert beneficial effects on health, including maintaining bone mass (22,23).…”

Maize Purple Plant Pigment Protects Against Fluoride-Induced Oxidative Damage of Liver and Kidney in Rats

“…The mechanisms by which fluoride produces such effects are still not clear. There is abundant literature reporting that fluoride increased the generation of reactive oxygen species (ROS) and free radicals, causes extensive oxidative stress and excessive lipid peroxidation, and reduces antioxidant enzyme activities in vivo or in vitro [3]. The oxidative stress has been considered an important mechanism of fluoride intoxication [4].…”

Mechanisms Underlying Endothelin-1 Level Elevations Caused by Excessive Fluoride Exposure

“…Generally, ET-1 synthesis is influenced by many factors, such as oxidative stress [16]. It is well-documented that oxidative stress plays an important role in the pathogenesis of endemic fluorosis [26][27][28]. Therefore, based on the data described above [25], we inferred that oxidative stress may be a modulator of fluoride-induced ET-1 over-expression.…”