Evaluation of Total Serum Immunoglobulin E level in Asthmatic Children and its Relation to Disease Severity

Abstract

Background Asthma is a multifaceted disease marked by recurrent airway inflammation. The aim of the study is to evaluate the significance of total immunoglobulin E (IgE) in asthmatic children and find the relation of its level to the disease severity Patients and methods Forty-five children with acute bronchial asthma aged between 5 and 16 years, and 15 control children with comparable age and sex distribution were included in the study. All children will be subjected to complete blood picture, Total IgE, and spirometry test Forced Expiratory Volume (FEV1), Forced Vital Capacity (FVC), FEV1/FVC. Results Among the 45 patients, 57.8% were male, with a median age of 10 years. There were statistically significant differences between the asthmatic groups and the control group as regards sex, weight, total IgE level, FEV1, FVC, and FEV1/FVC ratio. There was a significant positive correlation between IgE level and age, weight and height (r=0.465, P< 0.001, r=0.349, P=0.019, r=0.314, P=0.036, respectively) Conclusion Total IgE level was shown to have a role in the diagnosis of asthma and can be used as a predictor of asthma severity in children