Evaluation of toxicity and biodegradability of choline chloride based deep eutectic solvents

Radošević, Kristina; Bubalo, Marina Cvjetko; Srček, Višnja Gaurina; Grgas, Dijana; Dragičević, Tibela Landeka; Redovniković, Ivana Radojčić

doi:10.1016/j.ecoenv.2014.09.034

Cited by 576 publications

(373 citation statements)

References 38 publications

(56 reference statements)

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“…However, taking into account their potential application in the pharmaceutical industry and in the food production, Radošević et al 2015;Hayyan et al 2015 andWen et al 2015 conducted studies to assess the risk connected with the use of this kind of solvents as they are not well understood yet. What deserves special attention is the synergy effect between DES ingredients, which results in a greater toxicity of the mixture than the toxicity of each of its ingredients separately (Hayyan et al 2013b;Paiva et al 2014).…”

Section: Toxicity Of Deep Eutectic Solventsmentioning

confidence: 99%

Selected issues related to the toxicity of ionic liquids and deep eutectic solvents—a review

Kudłak

Owczarek

Namieśnik

2015

Environ Sci Pollut Res

299

133

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Green Chemistry plays a more and more important role in implementing rules of sustainable development to prevent environmental pollution caused by technological processes, while simultaneously increasing the production yield. Ionic liquids (ILs) and deep eutectic solvents (DESs) constitute a very broad group of substances. Apart from many imperfections, ILs and DESs have been the most promising discoveries in the world of Green Chemistry in recent years. The main advantage of ILs is their unique physicochemical properties-they are very desirable from the technological point of view, but apart from these benefits, ILs appear to be highly toxic towards organisms from different trophic levels. DES areas of usage are very spread, because they cover organic synthesis, extraction processes, electrochemistry, enzymatic reactions and many others. Moreover, DESs seem to be a less toxic alternative to ionic liquids. New possibilities of applications and future development trends are sought and presented, including such important solutions of life branches as pharmaceuticals' production and medicine.

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Section: Toxicity Of Deep Eutectic Solventsmentioning

confidence: 99%

Selected issues related to the toxicity of ionic liquids and deep eutectic solvents—a review

Kudłak

Owczarek

Namieśnik

2015

Environ Sci Pollut Res

299

133

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“…Due to its good solvent capacity, non-toxicity, biodegradability and economical synthesis, choline chloride ([Ch]Cl) is by far the most common compound used in DES formulation [2,7,8]. Usually, [Ch]Cl is combined with safe hydrogen bond donors such as polyols, urea, carboxylic acids or sugars [1,9,10], and their main applications include organic synthesis, biocatalysis and electrochemistry [2,7,11].…”

Section: Introductionmentioning

confidence: 99%

Indirect assessment of the fusion properties of choline chloride from solid-liquid equilibria data

Fernández

Silva

Martins

et al. 2017

Fluid Phase Equilibria

105

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a b s t r a c tThe temperature and enthalpy of fusion of choline chloride -[Ch]Cl-are not directly measurable since this compound decomposes upon melting. Yet, given the wide use of this compound in the preparation of deep eutectic solvents (DES), its thermophysical fusion properties are very important for a better understanding of these mixtures and the thermodynamic description of their solid-liquid phase diagrams. In this work, the fusion properties of choline chloride were estimated using the solubility curves of choline chloride in ten different ionic compounds, forming simple binary eutectic mixtures with quasiideal liquid phases. Experimental solid-liquid equilibria data for these systems -[Ch]Cl þ ionic compounds-were measured, and the ideality of the systems assessed through the quantification of the activity coefficients and their comparison in each pair of binary solutions. The values estimated for the fusion properties of choline chloride are T fus, [Ch]Cl ¼ 597 ± 7 K and D fus H [Ch]Cl ¼ 4300 ± 600 J mol À1 . These were additionally checked by thermodynamic consistency tests and by the prediction of the solid-liquid curves with COSMO-RS model. The results obtained with both procedures allow us to guarantee the usefulness and robustness of the estimated data.

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“…glycerine, ethylene glycol, triethylene glycol and urea have been studied through in vitro and in vivo studies and they were found to be less toxic than ionic liquids [25,26]. Choline chloride: glucose and choline chloride: glycerol displayed low cytotoxic effects [27]. Recently, ethylene glycol and glycerol DESs with choline chloride were found to be biodegradable under lower concentrations [28].…”

Section: Introductionmentioning

confidence: 98%

Ammonium-based deep eutectic solvents as novel soil washing agent for lead removal

Mukhopadhyay

Mukherjee

Adnan

et al. 2016

Chemical Engineering Journal

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Evaluation of toxicity and biodegradability of choline chloride based deep eutectic solvents

Cited by 576 publications

References 38 publications

Selected issues related to the toxicity of ionic liquids and deep eutectic solvents—a review

Selected issues related to the toxicity of ionic liquids and deep eutectic solvents—a review

Indirect assessment of the fusion properties of choline chloride from solid-liquid equilibria data

Ammonium-based deep eutectic solvents as novel soil washing agent for lead removal

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