2010
DOI: 10.2147/ijgm.s9156
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Evaluation of toxicological and antioxidant potential of Nardostachys jatamansi in reversing haloperidol-induced catalepsy in rats

Abstract: An aqueous root extract from Nardostachys jatamansi was investigated for its antioxidant and anticataleptic effects in the haloperidol-induced catalepsy rat model of the disease by measuring various behavioral and biochemical parameters. Catalepsy was induced by administration of haloperidol (1 mg/kg, ip) in male albino rats. A significant (P  0.01) reduction in the cataleptic scores were observed in all the drug-treated groups as compared to the haloperidol-treated group; with maximum reduction observed in t… Show more

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Cited by 12 publications
(5 citation statements)
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“…89 Anticataleptic Behavioural, metabolic, and neurotransmitter levels in the haloperidol-induced catalepsy rat model of the illness using hydroalcoholic root extract. 90 Hypertension Extremely promising, safe, and successful medication when used in conjunction with dietary changes and lifestyle modifications to treat individuals with essential hypertension. 91…”
Section: Haematopoietic Activitymentioning
confidence: 99%
“…89 Anticataleptic Behavioural, metabolic, and neurotransmitter levels in the haloperidol-induced catalepsy rat model of the illness using hydroalcoholic root extract. 90 Hypertension Extremely promising, safe, and successful medication when used in conjunction with dietary changes and lifestyle modifications to treat individuals with essential hypertension. 91…”
Section: Haematopoietic Activitymentioning
confidence: 99%
“…However, all drugtreated groups showed a substantial reduction in cataleptic ratings and appear greatest reduction. (Lyle et al, 2009;Rasheed et al, 2010).…”
Section: Biological Processesmentioning
confidence: 99%
“…Assim, a administração do haloperidol induz a expressão de genes de resposta imediata que atuam como fatores de transcrição (ONIMUS et al, 2022). Para estudo dos mecanismos farmacológicos de drogas antipsicóticas que sejam antagonistas dos D2R no estriado, são utilizadas estratégias experimentais como o teste da catalepsia induzida por haloperidol (SANBERG et al, 1988;DEL BEL, et al, 2002;RASHEED et al, 2010)…”
Section: Lista De Figurasunclassified
“…Animais tratados com haloperidol ficam impossibilitados mover os membros por um período prolongado assemelhando-se com os sintomas parkinsonianos (bradicinesia), esquizofrenia catatônica e outras fisiopatologias associados aos núcleos da base (SANBERG et al, 1988). O estado cataléptico dos roedores pode ser avaliado colocando o animal em uma posição incomum e registrando o tempo necessário para corrigir esta postura (SANBERG et al, 1988;DEL BEL et al, 2002;RASHEED et al, 2010). O teste de catalepsia pode ser realizado através de diferentes aparatos, sendo o teste na barra horizontal o mais amplamente utilizado (KUSCHINSKY e HORNYKIEWICZ, 1972).…”
Section: O Teste De Catalepsiaunclassified
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