Evaluation of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid accumulation in low-grade glioma in chemically induced rat models: PET and autoradiography compared with morphological images and histopathological findings

Doi, Yoshihiro; Kanagawa, Masaru; Maya, Yoshifumi; Tanaka, Akihiro; Oka, Shuntaro; Nakata, Norihito; Toyama, Masahito; Matsumoto, Hiroki; Shirakami, Yoshifumi

doi:10.1016/j.nucmedbio.2015.04.008

Cited by 13 publications

(8 citation statements)

References 25 publications

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“…Intratumoral cell density generally increases with tumor progression, and the transport activity of system ASC, but not of system L, decreases with increasing cell density [38]. We recently demonstrated that [ 18 F]fluciclovine accumulation is positively correlated with cell density in a rat glioma model [39]. In addition, the pH in progressive tumor tissue is comparatively acidic [40], and the transport activities of [ 14 C]fluciclovine by Na + -dependent AATs including system ASC are diminished, whereas the activity of Na + -independent AATs including system L increased under low pH conditions [24].…”

Section: Discussionmentioning

confidence: 90%

[14C]Fluciclovine (alias anti-[14C]FACBC) uptake and ASCT2 expression in castration-resistant prostate cancer cells

Ono

Oka

Okudaira

et al. 2015

Nuclear Medicine and Biology

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Section: Discussionmentioning

confidence: 90%

[14C]Fluciclovine (alias anti-[14C]FACBC) uptake and ASCT2 expression in castration-resistant prostate cancer cells

Ono

Oka

Okudaira

et al. 2015

Nuclear Medicine and Biology

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“…Therefore, there is an urgent need for techniques that facilitate early diagnosis, accurate tumor delineation, and detection of the most malignant regions for, e.g., surgery and therapy planning [ 2 ]. Whereas magnetic resonance imaging (MRI) can be used for tumor detection, the exact circumscription of brain tumors, such as gliomas with MRI, is complicated by their diffusely infiltrative character [ 3 , 4 , 5 , 6 ]. Positron emission tomography (PET) with radiolabeled amino acids is a promising alternative for the imaging of such tumors.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of 3-l- and 3-d-[18F]Fluorophenylalanines as PET Tracers for Tumor Imaging

Krämer

Gröner

Hoffmann

et al. 2021

Cancers

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Purpose: The preclinical evaluation of 3-l- and 3-d-[18F]FPhe in comparison to [18F]FET, an established tracer for tumor imaging. Methods: In vitro studies were conducted with MCF-7, PC-3, and U87 MG human tumor cell lines. In vivo µPET studies were conducted in healthy rats with/without the inhibition of peripheral aromatic l-amino acid decarboxylase by benserazide pretreatment (n = 3 each), in mice bearing subcutaneous MCF-7 or PC-3 tumor xenografts (n = 10), and in rats bearing orthotopic U87 MG tumor xenografts (n = 14). Tracer accumulation was quantified by SUVmax, SUVmean and tumor-to-brain ratios (TBrR). Results: The uptake of 3-l-[18F]FPhe in MCF-7 and PC-3 cells was significantly higher relative to [18F]FET. The uptake of all three tracers was significantly reduced by the suppression of amino acid transport systems L or ASC. 3-l-[18F]FPhe but not 3-d-[18F]FPhe exhibited protein incorporation. In benserazide-treated healthy rats, brain uptake after 42–120 min was significantly higher for 3-d-[18F]FPhe vs. 3-l-[18F]FPhe. [18F]FET showed significantly higher uptake into subcutaneous MCF-7 tumors (52–60 min p.i.), while early uptake into orthotopic U87 MG tumors was significantly higher for 3-l-[18F]FPhe (SUVmax: 3-l-[18F]FPhe, 107.6 ± 11.3; 3-d-[18F]FPhe, 86.0 ± 4.3; [18F]FET, 90.2 ± 7.7). Increased tumoral expression of LAT1 and ASCT2 was confirmed immunohistologically. Conclusion: Both novel tracers enable accurate tumor delineation with an imaging quality comparable to [18F]FET.

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“…Importantly, this study revealed a relationship between the serum level of occludin and the severity of brain edema in patients with brain tumors. Previous investigations have confirmed that peritumoral brain edema is vascular edema caused by damage to the BBB [ 17 – 19 ]. Occludin is an important component of tight junctions that constitute the BBB.…”

Section: Discussionmentioning

confidence: 93%

Peripheral Blood Occludin Level as a Biomarker for Perioperative Cerebral Edema in Patients with Brain Tumors

et al. 2020

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Objective. Cerebral edema is a common complication of brain tumors in the perioperative period. However, there is currently no reliable and convenient method to evaluate the extent of brain edema. The objective is to explore the effectiveness of serum occludin on predicting the extent of perioperative brain edema and outcome in patients with brain tumors. Methods. This prospective study enrolled 55 patients with brain tumors and 24 healthy controls in Sanbo Brain Hospital from June 2019 through November 2019. Serum occludin levels were measured preoperatively and on postoperative day 1. Peritumoral edema was assessed preoperatively using MRI. Pericavity brain edema on postoperative day 1 was evaluated using CT. Results. Compared with healthy controls, the serum occludin level was higher in patients with brain tumors both preoperatively and postoperatively (P<0.001). The serum occludin level correlated positively with the degree of brain edema preoperatively (r=0.78, P<0.001) and postoperatively (r=0.59, P<0.001). At an optimal cutoff of 3.015 ng/mL, the preoperative serum occludin level discriminated between mild and severe preoperative brain edema with a sensitivity of 90.48% and specificity of 84.62%. At an optimal cutoff value of 3.033 ng/mL, the postoperative serum occludin level distinguished between mild and severe postoperative brain edema with a sensitivity of 97.30% and specificity of 55.56%. Conclusions. The serum occludin level is associated with cerebral edema and could potentially be used as a biomarker for perioperative cerebral edema. This trial is registered with ChiCTR1900023742.

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Evaluation of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid accumulation in low-grade glioma in chemically induced rat models: PET and autoradiography compared with morphological images and histopathological findings

Cited by 13 publications

References 25 publications

[14C]Fluciclovine (alias anti-[14C]FACBC) uptake and ASCT2 expression in castration-resistant prostate cancer cells

[14C]Fluciclovine (alias anti-[14C]FACBC) uptake and ASCT2 expression in castration-resistant prostate cancer cells

Evaluation of 3-l- and 3-d-[18F]Fluorophenylalanines as PET Tracers for Tumor Imaging

Peripheral Blood Occludin Level as a Biomarker for Perioperative Cerebral Edema in Patients with Brain Tumors

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