Evaluation of treatment outcomes in patients with supraglottic laryngeal cancer in Ontario, Canada: A population‐based study

Hall, Stephen F.; Griffiths, Rebecca

doi:10.1002/hed.25073

Cited by 4 publications

(6 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The index is based on a 5-year lookback window of hospitalizations. It is a summative scale that considers 31 domains, and we used cut-points of 0, 1, 2, and more than 2 25,26 , with greater comorbidity resulting in higher scores.…”

Section: Variablesmentioning

confidence: 99%

“…In the ocr dataset, TNM categories and stage groups were not reliably available for patients with hnc during the period of interest 26 . We created a surrogate for extent of disease based on surgical billing codes for total resection (T3-4), partial resection (T1-2), and neck dissection (N0 or N+) to create 3 groups: early, early N+, and advanced (Table i).…”

Section: Extent Of Diseasementioning

confidence: 99%

See 1 more Smart Citation

Does the Frequency of Routine Follow-Up after Curative Treatment for Head-and-Neck Cancer Affect Survival?

et al. 2019

View full text Add to dashboard Cite

Background: Routine follow-up is a cornerstone of oncology practice but evidence is lacking to support most aspects. Our Objective was to investigate the relationship between frequency of routine follow-up and survival.Methods: A population-based study using electronic health-care data based on 5310 patients from Ontario diagnosed with squamous cell head and neck cancer between 2007 and 2012. Treatments included surgery (24.6%), radiotherapy +/- chemotherapy (52.4%) and combined surgery and radiotherapy (23%). We determined the follow-up oncologist for each patient, calculated the average follow-up visits over 2.5 years for all the patients of each oncologist and compared by treatment the overall survival of the patients for the high, medium and low follow-up oncologist groups using Kaplan Meier and multiple variable regression analysis. Results: Many oncologists saw patients 40 to 80% more often than others. There was no relationship between appointment frequency and survival for patients for any treatment group.Conclusion: The practice of routine follow-up varies and is costly to both a health care system and to patients. Without evidence on the effectiveness of our current policies further research is required to investigate new or optimal practices.

show abstract

Section: Variablesmentioning

confidence: 99%

Section: Extent Of Diseasementioning

confidence: 99%

Does the Frequency of Routine Follow-Up after Curative Treatment for Head-and-Neck Cancer Affect Survival?

et al. 2019

View full text Add to dashboard Cite

show abstract

“…1 Supraglottic cancer (SC), which accounts for 30%-40% of patients with laryngeal cancers, is characterized by a high rate of lymph node metastases, even in earlystage tumors (T1-2). 2 The high lymph node metastasis rate contributes to a worse prognosis in SC than with glottic cancer. 3 Therefore, reducing lymph node Abbreviations: cN0, clinically negative cervical lymph nodes; ELNs, examined lymph nodes; HR, hazard ratio; LND, lymph node dissection; OS, overall survival; PSM, propensity score matching; SC, supraglottic cancer; SEER, Surveillance, Epidemiology, and End Results program.…”

Section: Introductionmentioning

confidence: 99%

“…Laryngeal cancer remains the second most common malignant tumor of the upper respiratory tract 1 . Supraglottic cancer (SC), which accounts for 30%–40% of patients with laryngeal cancers, is characterized by a high rate of lymph node metastases, even in early‐stage tumors (T1–2) 2 . The high lymph node metastasis rate contributes to a worse prognosis in SC than with glottic cancer 3 .…”

Section: Introductionmentioning

confidence: 99%

The survival benefit of lymph node dissection in resected T1–2, cN0 supraglottic cancer: A population‐based propensity score matching analysis

et al. 2020

View full text Add to dashboard Cite

Background: The survival benefit of clinically negative cervical lymph nodes (cN0) in patients with T1-2 supraglottic cancer (SC) remains unclear. This study aimed to comprehensively evaluate the prognostic value of lymph node dissection (LND) in patients with T1-2, cN0 SC. Methods: We included 1036 confirmed T1-2, cN0 SC patients with clinicopathological characteristics between 2004 and 2015, based on the Surveillance, Epidemiology, and End Results program (SEER) database. The association between LND and overall survival (OS) was investigated by the Kaplan-Meier method. Results: Before propensity score matching (PSM), patients selected for LND had better OS, compared to patients did not receive LND (5-year OS: 62.6% vs 51.2%, respectively; p = 0.011). After PSM, the LND group also present significant improvement in prognosis (5-year OS: 64.3% vs 51.7%, respectively; p < 0.01). Conclusions: LND was significantly associated with a more favorable prognosis compared with non-LND in patients with T1-2, cN0 SC.

show abstract

“… Area‐level socioeconomic status (SES) of location‐specific income quintiles was based on Statistics Canada 2006 census data matched to postal codes providing data at level of enumeration units (neighborhoods) Comorbidity was estimated using the Elixhauser Index based on hospital discharge data with look back of 2 years (1/1/2006 to 12/31/2007). Elixhauser created a summative scale over 31 domains for administrative data and we used the cut‐points of 0, 1, 2, >2 with greater comorbidity creating higher scores Time on study was the number of consecutive patient days from 1/1/2008 to the earliest date of death, loss OHIP eligibility or end of study period (12/31/2012). Rurality was based on the Statistics Canada Postal Code Conversion File from the 2006 census and reported by Metropolitan Influence Zones (MIZ). …”

Section: Methodsmentioning

confidence: 99%

Do doctors who order more routine medical tests diagnose more cancers? A population‐based study from Ontario Canada

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background The overuse of medical tests leads to higher costs, wasting of resources, and the potential for overdiagnosis of disease. This study was designed to determine whether the patients of family doctors who order more routine medical tests are diagnosed with more cancers. Method A retrospective population‐based cross‐sectional study using administrative health care data in Ontario Canada. We investigated the ordering of 23 routine laboratories and imaging tests 2008‐20012 by 6849 Ontario family physicians on their 4.9 million rostered adult patients. We compared physicians’ test utilization and calculated case‐mix adjusted observed to expected (O:E) utilization ratios to categorize physicians as Typical, Higher or Lower testers. Age‐sex standardized rates (cases/10 000 patient years) and Rate Ratios were determined for cancers of the thyroid, prostate, breast, lymphoma, kidney, melanoma, uterus, ovary, lung, esophagus, and pancreas for each tester group. Results There was wide variation in the use of the 23 tests by Ontario physicians. 26% and 24% of physicians were deemed Higher Testers for laboratory and imaging tests, while 41% and 38% were Typical Testers. The patients of higher test users were diagnosed with more cancers of thyroid (laboratory [RR 1.61, 95% CI 1.39‐1.87] and imaging [RR 2.08, 95% CI 0.88‐2.30]) and prostate (laboratory [RR 1.10, 95% CI 1.03‐1.18] and imaging [RR 1.05, 95% CI 1.00‐1.10]). Conclusion There is a wide variation in the ordering of routine and common medical tests among Ontario family doctors. The patients of higher testers were diagnosed with more thyroid and prostate cancers.

show abstract

Evaluation of treatment outcomes in patients with supraglottic laryngeal cancer in Ontario, Canada: A population‐based study

Abstract: The addition of CRT by head and neck oncologists in Ontario, Canada, did not improve outcomes for the "real world" patients with supraglottic laryngeal carcinoma.

Cited by 4 publications

References 35 publications

Does the Frequency of Routine Follow-Up after Curative Treatment for Head-and-Neck Cancer Affect Survival?

Does the Frequency of Routine Follow-Up after Curative Treatment for Head-and-Neck Cancer Affect Survival?

The survival benefit of lymph node dissection in resected T1–2, cN0 supraglottic cancer: A population‐based propensity score matching analysis

Do doctors who order more routine medical tests diagnose more cancers? A population‐based study from Ontario Canada

Contact Info

Product

Resources

About