Evaluation of TRIM5 and TRIM22 polymorphisms on treatment responses in Iranian patients with chronic hepatitis C virus infection

Mobasheri, Setareh; Irani, Nazanin; Sepahi, Abbas Akhavan; Sakhaee, Fatemeh; Jamnani, Fatemeh Rahimi; Vaziri, Farzam; Siadat, Seyed Davar; Fateh, Abolfazl

doi:10.1016/j.gene.2018.07.023

Cited by 11 publications

(13 citation statements)

References 28 publications

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“…Similar findings were reported among HIV-1 positive Caucasian homosexual men enrolled in the Amsterdam cohort Studies (ACS) [14]. The role of rs3824949 genotype has also been observed in other diseases, with the GG genotype being associated with rapid antiretroviral treatment response compared to the CG and CC genotypes among Hepatitis C infected individuals [19,20]. Since the CG genotype was seen among non-controllers in our study, it may not be of any significance in HIV disease progression.…”

Section: Discussionsupporting

confidence: 87%

Variations in Trim5α and Cyclophilin A genes among HIV-1 elite controllers and non controllers in Uganda: a laboratory-based cross-sectional study

et al. 2020

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Background: Tripartite Motif Containing 5 alpha (TRIM5α), a restriction factor produced ubiquitously in cells and tissues of the body plays an important role in the immune response against HIV. TRIM5α targets the HIV capsid for proteosomal destruction. Cyclophilin A, an intracellular protein has also been reported to influence HIV infectivity in a cell-specific manner. Accordingly, variations in TRIM5α and Cyclophilin A genes have been documented to influence HIV-1 disease progression. However, these variations have not been documented among Elite controllers in Uganda and whether they play a role in viral suppression remains largely undocumented. Our study focused on identifying the variations in TRIM5α and Cyclophilin A genes among HIV-1 Elite controllers and non-controllers in Uganda. Results: From the sequence analysis, the rs10838525 G > A mutation in exon 2 of TRIM5α was only found among elite controllers (30%) while the rs3824949 in the 5′UTR was seen among 25% of the non-controllers. In the Cyclophilin A promoter, rs6850 was seen among 62.5% of the non-controllers and only among 10% elite controllers. Furthermore, rs17860048 in the Cyclophillin A promoter was predominantly seen among elite controllers (30%) and 12.5% noncontrollers. From gene expression analysis, we noted that the respective genes were generally elevated among elite controllers, however, this difference was not statistically significant (TRIM5α p = 0.6095; Cyclophilin A p = 0.6389). Conclusion: Variations in TRIM5α and Cyclophillin A promoter may influence HIV viral suppression. The rs10838525 SNP in TRIM5α may contribute to viral suppression among HIV-1 elite controllers. The rs6850 in the cyclophillin A gene may be responsible for HIV-1 rapid progression among HIV-1 non-controllers. These SNPs should be investigated mechanistically to determine their precise role in HIV-1 viral suppression.

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Section: Discussionsupporting

confidence: 87%

Variations in Trim5α and Cyclophilin A genes among HIV-1 elite controllers and non controllers in Uganda: a laboratory-based cross-sectional study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Similar ndings were reported among HIV-1 positive Caucasian homosexual men enrolled in the Amsterdam cohort Studies (ACS) (14). The role of rs3824949 genotype has also been observed in other diseases, with the GG genotype being associated with rapid antiretroviral treatment response compared to the CG and CC genotypes among Hepatitis C infected individuals (19,20). Since the CG genotype was seen among non-controllers in our study, it may not be of any signi cance in HIV disease progression.…”

Section: Discussionsupporting

confidence: 87%

Variations In Trim5α And Cyclophilin A Genes Among HIV-1 Elite Controllers and Non Controllers In Uganda; A Laboratory-Based Cross-sectional study

Amanya

Nyiro

Waswa

et al. 2020

Preprint

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Background Tripartite Motif Containing 5 alpha (TRIM5α), a restriction factor produced ubiquitously in cells and tissues of the body plays an important role in the immune response against HIV. TRIM5α targets the HIV capsid for proteosomal destruction. Cyclophilin A, an intracellular protein has also been reported to influence HIV infectivity in a cell-specific manner. Accordingly, variations in TRIM5α and Cyclophilin A genes have been documented to influence HIV-1 disease progression. However, these variations have not been documented among Elite controllers in Uganda and whether they play a role in viral suppression remains largely undocumented. Our study focused on identifying the variations in TRIM5α and Cyclophilin A genes among HIV-1 Elite controllers and non-controllers in Uganda.Results From the sequence analysis, the rs10838525 G>A mutation in exon 2 of TRIM5α was only found among elite controllers (30%) while the rs3824949 in the 5’UTR was seen among 25% of the non-controllers. In the Cyclophilin A promoter, rs6850 was seen among 62.5% of the non-controllers and only among 10% elite controllers. Furthermore, rs17860048 in the Cyclophillin A promoter was predominantly seen among elite controllers (30%) and 12.5% non-controllers. From gene expression analysis, we noted that the respective genes were generally elevated among elite controllers, however, this difference was not statistically significant (TRIM5α p=0.6095; Cyclophilin A p=0.6389). Conclusion Variations in TRIM5α and Cyclophillin A promoter may influence HIV viral suppression. The rs10838525 SNP in TRIM5α may contribute to viral suppression among HIV-1 elite controllers. The rs6850 in the cyclophillin A gene may be responsible for HIV-1 rapid progression among HIV-1 non-controllers. These SNPs should be investigated mechanistically to determine their precise role in HIV-1 viral suppression.

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“…The rs3824949 in the 5'UTR of TRIM5α seen more among HIV-1 non-controllers(25%). Whereas the role of this SNP has not been reported in HIV disease progression, there are reports that it is associated with rapid antiretroviral treatment response among Hepatitis C infected individuals (16,17). These findings point to the potential role of rs3824949 SNP in antiviral treatment response including HIV treatment response.…”

Section: Discussionmentioning

confidence: 86%

Variations In Trim5α and Cyclophilin A Genes Among HIV-1 Elite Controllers and Non Controllers in Uganda; A Laboratory-Based Cross-Sectional Study

Amanya

Nyiro

Waswa

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Tripartite Motif Containing 5 alpha (TRIM5α), a restriction factor produced ubiquitously in cells and tissues of the body plays an important role in the immune response against HIV. TRIM5α targets the HIV capsid for proteosomal destruction. Cyclophilin A, an intracellular protein has also been reported to influence HIV infectivity in a cell-specific manner. Accordingly, variations in TRIM5α and Cyclophilin A genes have been documented to influence HIV-1 disease progression. However, these variations have not been documented among Elite controllers in Uganda and whether they play a role in viral suppression remains largely undocumented. Our study focused on identifying the variations in TRIM5α and Cyclophilin A genes among HIV-1 Elite controllers and non-controllers in Uganda.Results From the sequence analysis, the rs10838525 G > A mutation in exon 2 of TRIM5α was found only among elite controllers (30%) while the rs3824949 in the 5’UTR was seen among 25% of the non-controllers. In the Cyclophilin A promoter, rs6850 was seen among 62.5% of the non-controllers and only among 10% elite controllers. Furthermore, rs17860048 in the Cyclophillin A promoter was predominantly seen among elite controllers (30%) and 12.5% non-controllers. From gene expression analysis, we noted that the respective genes were generally elevated among elite controllers, however, this difference was not statistically significant (TRIM5α p = 0.6095; Cyclophilin A p = 0.6389).Conclusion Variations in TRIM5α and Cyclophillin A promoter may influence HIV viral suppression. The rs10838525 SNP in TRIM5α may contribute to viral suppression among HIV-1 elite controllers. The rs6850 in the cyclophillin A gene may be responsible for HIV-1 rapid progression among HIV-1 non-controllers. These SNPs should be investigated mechanistically to determine their precise role in HIV-1 viral suppression.

show abstract

Evaluation of TRIM5 and TRIM22 polymorphisms on treatment responses in Iranian patients with chronic hepatitis C virus infection

Cited by 11 publications

References 28 publications

Variations in Trim5α and Cyclophilin A genes among HIV-1 elite controllers and non controllers in Uganda: a laboratory-based cross-sectional study

Variations in Trim5α and Cyclophilin A genes among HIV-1 elite controllers and non controllers in Uganda: a laboratory-based cross-sectional study

Variations In Trim5α And Cyclophilin A Genes Among HIV-1 Elite Controllers and Non Controllers In Uganda; A Laboratory-Based Cross-sectional study

Variations In Trim5α and Cyclophilin A Genes Among HIV-1 Elite Controllers and Non Controllers in Uganda; A Laboratory-Based Cross-Sectional Study

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