Evaluation of True Vitamin B12 Deficiency in a Group of Jordanians Aged 20-40 Years Visiting the Jordan University Hospital

Qutob, Maysoun S.; Takruri, Hamed R.; Barghouti, Farihan

doi:10.3923/pjn.2011.343.349

Cited by 6 publications

(6 citation statements)

References 7 publications

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“…There was statistical significant difference observed b/n male and female athletes in their red blood cell, hemoglobin and ferritin; which all these are expected naturally from biological and physiological gender variation, however this difference was not observed for folate and vitamin B 12. This finding agrees with a study conducted in Jordan with absence of differences in vitamin B 12 status of among 20–40 years old healthy male and female individuals [ 27 ]. In addition there is no sex dependent cut off points for Folate and vitamin B 12 by WHO, NIH, CDC and other worldwide health organizations.…”

Section: Discussionsupporting

confidence: 93%

Iron, folate and vitamin B12 status of Ethiopian professional runners

Habte

Adish²,

Zerfu

et al. 2015

Nutr Metab (Lond)

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BackgroundBetter macro and micro nutrient status and their adequate intake by the athletes have great role in balancing losses associated with strenuous exercise, then for better performance. The objective of this study was to determine iron, folate and vitamin B12 status of Ethiopian professional athletes.MethodsA cross sectional study was conducted using a point time convenient sample of 101 male and female Ethiopian professional athletes of different distance categories in the period of February to April 2014. Biochemical samples, detail health and exercise related interview, performance data, 24 h dietary diversity and weekly food frequency were collected.ResultsThe low, medium and high dietary diversity terciles were 36.1, 60.9 and 3.3 % respectively. The mean ± Sd of dietary diversity was 5.44 ± 1.8. Prevalence of iron overload (Serum ferritin >200 μg/L) was 11 %, whereas that of anemia (Hb < 12 g/dL), iron deficiency (ferritin < 12 μg/L) and moderate folate deficiency (<5.9 ng/mL) was 3, 2 and 20.8 % respectively. There was no iron deficiency anemia case in the study. In this study, the mean serum vitamin B12 concentration was 561 ± 231 pg/ml with a minimum and maximum value of 210 and 1736 pg/ml respectively, and there was no deficiency for this nutrient (>210 pg/ml). The iron status of male athletes was significantly different by running-distance categories. In contrast, such difference was absent for female athletes. Performance of the athletes was associated with their red blood cell count (RBC) at p = 0.03. The high performer athletes exhibited high mean value of micronutrient status and hematological variables than their counter parts. However, the RBC of the athletes was the only parameter whose association was statistically significant.ConclusionsThe observed gender difference in the association of running-distance category with iron and folate in this study needs further investigation. Given the 11 % iron overload in the present study; there is a need of awarance creation activities and diet intervention in the athletics federation, the athletes and the coaches in order not aggravate the present overload. Prescription of supplements such as iron-folate, multivitamins and minerals should not be based on broad spectrum rather it should be based on recent history of confirmed deficiency, clinical signs and/or laboratory testing to prevent trace element toxicity.

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Section: Discussionsupporting

confidence: 93%

Iron, folate and vitamin B12 status of Ethiopian professional runners

Habte

Adish²,

Zerfu

et al. 2015

Nutr Metab (Lond)

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“…Herein, the level of vitamin B12 showed a significant association with the level of Hb (P = 0.044). On the contrary, Qutob et al have shown that there was no correlation between B12 status and Hb (p=0.545) 63 . Additionally, we observed a statistically significant positive correlation between RBCs count and vitamin B12 level (r= 0.354, p=0.001).…”

Section: Discussionmentioning

confidence: 90%

“…The current findings did not report a difference in the vitamin B12 deficiency between age groups, < 40 years and > 40 years (P =0.119), which is consistent with the results of a previous study 62 . On the other hand, most studies showed a significant association between vitamin B12 deficiency and age 54,63,67,68 . In another previous survey that evaluated vitamin B12 deficiency in Jordan for participants whose ages ranged between 19 and 90, the study concluded that mean serum vitamin B12 levels rise with age, however, individuals aged < 40 years had the lowest vitamin B12 levels among all ages, which is consistent with our findings 16 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin B12 Deficiency in the South of Jordan: A Possible Geographical Correlation

Qar¹,

Zoubi²,

Azzam³

et al. 2020

Preprint

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Objectives: Vitamin B12 deficiency has been associated with certain serious disorders such as megaloblastic anemia as well as cardiovascular, neurological, and psychological disorders. Vitamin B12 deficiency is a worldwide health concern and a severe health problem in certain developing countries. In the current study, we aimed to evaluate the situation of vitamin B12 and estimate the prevalence of vitamin B12 deficiency in southern Jordan. Methods: The study population included 281 participants from Aqaba city: 71.2% females and 28.8% males with a mean age of 30.01±13.5. Results: The results showed that the average vitamin B12 level was 277.34±103.70 pg/mL. The study population showed that 69 (24.6%) participants had a vitamin B12 deficiency. The current findings showed a lower frequency of vitamin B12 deficiency in the studied population compared to the rest of Jordan, especially in the north. The females reported a significantly higher frequency of vitamin B12 deficiency (29.0%) compared to the male group (13.6%). In addition, the CBC parameters showed a significant association between the level of vitamin B12 and Hb, RBC, PCV, and platelet count with a p-value = 0.044, <0.001, 0.021, 0.025, respectively. On the other hand, the results showed a lack of association between the vitamin B12 level and MCV and age group. Conclusion: In conclusion, the current study supports our previous findings regarding the correlation between geographical locations and the deficiency of vitamin B12. These findings can be attributed to the lifestyle and nutrient situation in Aqaba city which relies more on seafood. Moreover, other factors such as genetic predisposition can be excluded as an association factor. Therefore, more studies are required to evaluate vitamin B12 levels in Jordan at a higher scale that will include genetic analysis as well as food habits.

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“…Several studies indicated a trend of a low level of serum vitamin B 12 in Jordanian adults (Hakooz et al, 2006;Barghouti et al, 2009;Qutob et al, 2011;El-Khateeb et al, 2014;El-Khateeb et al, 2019;Abu-Shanab et al, 2021). According to the researchers, the high frequency of low vitamin B 12 deserves the development of a strategy to correct this problem in Jordan.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a Jordanian commercial chocolate brand fortified with micronutrients of vitamins B12 and D3, iron and zinc

et al. 2023

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Chocolate is a preferred food for children and adults. Micronutrient deficiencies are still prevalent worldwide. This study aims to manufacture and evaluate a type of sugar-free dark chocolate fortified with vitamins and minerals. Three types of chocolate were fortified with vitamin D 3 , vitamin B 12 , and iron and zinc. The fortified chocolate was evaluated in terms of chemical composition using FTIR and DSC methods, visco-mechanical, sensory and stability. The FTIR studies indicated that the spectrum of all fortified chocolates was similar to that of the control, unfortified chocolate. The DSC studies indicated that there were no characteristics differences in crystallinity and degree of crystallization between the fortified and the control products. The addition of vitamins and minerals to chocolate strengthened the structure, increased the melting point, didn't cause significant variation in the rheological properties and had no significant effect on the overall sensation of the taste when compared with controlled chocolate. The stability results indicated that the fortified chocolate was stable for 9 months at room temperature. It was concluded that the fortified chocolate was a good vehicle for the vitamins and minerals with acceptable properties that may be used for supplementing vitamins and minerals.

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Evaluation of True Vitamin B12 Deficiency in a Group of Jordanians Aged 20-40 Years Visiting the Jordan University Hospital

Cited by 6 publications

References 7 publications

Iron, folate and vitamin B12 status of Ethiopian professional runners

Iron, folate and vitamin B12 status of Ethiopian professional runners

Vitamin B12 Deficiency in the South of Jordan: A Possible Geographical Correlation

Evaluation of a Jordanian commercial chocolate brand fortified with micronutrients of vitamins B12 and D3, iron and zinc

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