Evaluation of tumor markers for the differential diagnosis of benign and malignant ascites

Liu, Fang; Kong, Xinjuan; Dou, Qian; Ye, J.i.n.; Xu, Dong; Shang, Haitao; Xu, Ke; Song, Yufang

doi:10.1016/s1665-2681(19)30865-8

Cited by 46 publications

(47 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, it remains difficult in the clinic to differentiate benign and malignant ascites, particularly in the early diagnosis of malignant ascites . Currently, cytological detection of ascites has become a gold standard for confirming malignant ascites . This detection shows high specificity, but its sensitivity is low, which can easily result in misdiagnoses and repeated tests after multiple ascites collection, leading to delays in providing optimal therapeutic options and increased discomfort from abdominocentesis .…”

Section: Therapeutic Implications Of Targeting Tumor Microenvironmentmentioning

confidence: 99%

“…(65) Currently, cytological detection of ascites has become a gold standard for confirming malignant ascites. (66) This detection shows high specificity, but its sensitivity is low, which can easily result in misdiagnoses and repeated tests after multiple ascites collection, leading to delays in providing optimal therapeutic options and increased discomfort from abdominocentesis. (65) Our group previously suggested that a smaller amount of ascites may correlate with a good prognosis for patients with ovarian cancer.…”

Section: Therapeutic Implications Of Targeting Tumor Microenvironmentmentioning

confidence: 99%

See 1 more Smart Citation

Ascites modulates cancer cell behavior, contributing to tumor heterogeneity in ovarian cancer

2016

View full text Add to dashboard Cite

Malignant ascites constitute a unique tumor microenvironment providing a physical structure for the accumulation of cellular and acellular components. Ascites is initiated and maintained by physical and biological factors resulting from underlying disease and forms an ecosystem that contributes to disease progression. It has been demonstrated that the cellular contents and the molecular signatures of ascites change continuously during the course of a disease. Over the past decade, increasing attention has been given to the characterization of components of ascites and their role in the progression of ovarian cancer, the most malignant gynecologic cancer in women. This review will discuss the role of ascites in disease progression, in terms of modulating cancer cell behavior and contributing to tumor heterogeneity.

show abstract

Section: Therapeutic Implications Of Targeting Tumor Microenvironmentmentioning

confidence: 99%

Section: Therapeutic Implications Of Targeting Tumor Microenvironmentmentioning

confidence: 99%

Ascites modulates cancer cell behavior, contributing to tumor heterogeneity in ovarian cancer

2016

View full text Add to dashboard Cite

show abstract

“…Consecutive 165 patients with liver cirrhosis were enrolled in our study. The diagnosis of liver cirrhosis was based on a history of chronic liver disease, physical exam, and/or laboratory abnormalities and, importantly, the presence of signs of cirrhosis and/or portal hypertension (ascites, splenomegaly, and collateral circulation)30. Since all the patients with PAs-induced HSOS had ascites, the cirrhotic patients with ascites or previous episodes of ascites were enrolled in parallel with HSOS.…”

Section: Methodsmentioning

confidence: 99%

Diagnostic performance of Contrast-enhanced CT in Pyrrolizidine Alkaloids-induced Hepatic Sinusoidal Obstructive Syndrome

Kan

Rong

et al. 2016

Sci Rep

Self Cite

View full text Add to dashboard Cite

Hepatic sinusoidal obstruction syndrome (HSOS) can be caused by pyrrolizidine alkaloids(PAs)-containing herbals. Since PAs exposure is obscure and clinical presentation of HSOS is unspecific, it is challenge to establish the diagnosis of PAs-induced HSOS. Gynura segetum is one of the most wide-use herbals containing PAs. The aim of our study is to describe the features of contrast-enhanced computed tomography (CT) in gynura segetum-induced HSOS, and then determine diagnostic performance of radiological signs. We retrospectively analyzed medical records and CT images of HSOS patients (71 cases) and the controls (222 cases) enrolled from January 1, 2008, to Oct 31, 2015. The common findings of contrast CT in PAs-induced HSOS included: ascites (100%), hepatomegaly (78.87%), gallbladder wall thickening (86.96%), pleural effusion (70.42%), hepatic vein narrowing (87.32%), patchy liver enhancement (92.96%), and heterogeneous hypoattenuation (100%); of these signs, patchy enhancement and heterogeneous hypoattenuation were valuable features. Then, the result of diagnostic performance demonstrated that contrast CT possessed better performance in diagnosing PAs-induced HSOS compared with various parameters of Seattle criteria. In conclusion, the patients with PAs-induced HSOS display distinct radiologic features at CT-scan, which reveals that contrast-enhanced CT provides an effective noninvasive method for diagnosing PAs-induced HSOS.

show abstract

“…With the increasing application of multimodal therapy strategies, there also is an increasing number of secondary ascites forms related to portal hypertension, inflammation, hypoalbuminemia, etc. However, cytology remains the gold standard that allows for the definitive diagnosis with high specificity, although the sensitivity is only approximately 40% to 60% …”

Section: Introductionmentioning

confidence: 99%

“…However, cytology remains the gold standard that allows for the definitive diagnosis with high specificity, although the sensitivity is only approximately 40% to 60%. 10 Therefore, it remains a challenge to distinguish patients with PCA from patients with ascites related to benign conditions. In particular, patients with cirrhosis and ascites may develop spontaneous bacterial peritonitis (SBP), which occurs in 10% to 30% of cases.…”

Section: Introductionmentioning

confidence: 99%

Expression of microRNAs in the ascites of patients with peritoneal carcinomatosis and peritonitis

Schindler

Kupčinskas

Juzėnas

et al. 2018

Cancer Cytopathology

View full text Add to dashboard Cite

show abstract

Evaluation of tumor markers for the differential diagnosis of benign and malignant ascites

Cited by 46 publications

References 23 publications

Ascites modulates cancer cell behavior, contributing to tumor heterogeneity in ovarian cancer

Ascites modulates cancer cell behavior, contributing to tumor heterogeneity in ovarian cancer

Diagnostic performance of Contrast-enhanced CT in Pyrrolizidine Alkaloids-induced Hepatic Sinusoidal Obstructive Syndrome

Expression of microRNAs in the ascites of patients with peritoneal carcinomatosis and peritonitis

Contact Info

Product

Resources

About