Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug

Abstract

Background and objectives: Turmeric has assisted in the control of inflammation and pain for decades and has been used in combination with other nutraceuticals to treat acute and chronic osteoarthritis pain. Recently, the effect of turmeric, turmeric extract, or curcuminoids on musculoskeletal pain, either by themselves or in conjunction with other substances, has been reported. The aim of this study was to develop and characterize turmeric nanoparticles (T-NPs) for various parameters, both in vitro and in vivo. Materials and Methods: The T-NPs were successfully synthesized and characterized using particle size analysis, solubility improvement, SEM, EDX, X-ray diffraction, and in vivo antigout activity in mice model. Results: The T-NPs were of about 46 nm in size with a positive zeta potential +29.55 ± 3.44 and low polydispersity index (PDI) (0.264). Furthermore, the diseased mice, with induced gout via monosodium urate crystals, were treated with 5, 10, and 20 ppm T-NPs, administered orally, and the anti-gout potential was observed through measurement of joint diameter and changes in biochemical parameters, including lipid profile, renal function test, and liver function tests which significantly reduced the levels of these biochemical parameters. Conclusions: Uric acid levels were significantly reduced after the treatment with T-NPs. indicating that T-NPs show superior potential against gout management. Thus, T-NPs can be developed as an efficient antigout agent with minimum toxicities.

Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and In Vivo Evaluation

“…SNEDDS have shown excellent potential to enhance the oral bioavailability of highly lipophilic drugs [21]. Ex vivo permeation studies can mimic the potential improvement in drug permeability once inside the GIT [10]. The results of ex vivo permeation revealed a 3.2-fold increased permeation with LCT 14 across the rat intestine as compared to other formulations.…”

“…The most popular nano-based strategies for lipophilic drugs include incorporation of drugs in lipid vehicles like oil/surfactant dispersion [5], micro and nanoemulsions [6,7], and self emulsifying drug delivery systems. Self-nanoemulsifying drug delivery systems (SNEDDS) have emerged as a vital strategy for the efficient delivery of drugs with poor aqueous solubility [8,9,10]. SNEDDS are well known for their potential to enhance the solubility and absorption of the lipophilic drugs [11] by increasing the surface area and decreasing the size of oil droplets that are readily digestible and incorporated into mixed micelles that can pass the intestinal lumen [12].…”

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“…These study findings clearly demonstrate the influence of oil and surfactant on the ingression of constricted junctions and facilitation of the ACV transport through transcellular routes across the stratum corneum. It could be anticipated that the SNEDDS components contributed substantially in expediting the evasion of ACV through both the lipid structures of the interlamellar region and corneocytes with their keratin-enriched matrix of the skin’s transcellular routes [ 36 , 37 , 38 ].…”

Medicinal Plants Explain the Significant Role of Uric Acid for Malaria Parasite

“…Study done by Mustafa Kiyani M et al showed that; Uric acid concentrations were considerably decreased after treatment with turmeric nanoparticles (T-NPs), signifying that T-NPs show higher potential against gout control [10].…”