Evaluation of two commercial jet nebulisers and three compressors for the nebulisation of antibiotics.

Hung, J C; Hambleton, G; Super, Maurice

doi:10.1136/adc.71.4.335

Cited by 18 publications

(6 citation statements)

References 11 publications

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“…However, a constant flow of air is used to draw aerosol onto the filter which, as shown in this study, will lead to an inaccurate measurement of the drug output. A number of comparative studies has measured drug output from nebulizers under constant or no entraining flow [7][8][9]. The present data suggest that, for some nebulizers, these methods may give very misleading results.…”

Section: Discussionmentioning

confidence: 87%

Drug output from nebulizers is dependent on the method of measurement

Barry¹,

O’Callaghan²

1998

Eur Respir J

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The objective of this study was to determine whether current regulatory methods for assessing the output of nebulizers are appropriate for the delivery of nebulized steroid suspensions to patients. We studied a conventional jet nebulizer (the Intersurgical Cirrus), an open-vent nebulizer (the Medicaid Sidestream) and a breath-enhanced nebulizer (the Pari LC Plus), using a constant sampling flow or a sinusoidal pump to represent the breathing pattern of children from 6 months to adulthood. Recovery of budesonide released from the nebulizers onto filters was reduced when using breathing simulation compared with constant flow, and this reduction was greatest for the conventional nebulizer (Cirrus, 103 microg with constant flow to 4.4 microg with a 50 mL tidal volume; Pari, 176 microg to 25 microg). The open-vent nebulizer deposited very little budesonide on the filter at lower tidal volumes (4.5 microg with a 50 mL tidal volume), possibly because the enhanced flow of aerosol laden air was greater than the inspiratory flow from the breathing simulator. The output of the LC plus was reduced at high flow, from 176 microg at 20 L x min(-1) to 93 microg at 60 L x min(-1). Overall, the measured output varied by up to 700%, depending on the method used. These results suggest that breathing patterns dramatically alter the measured output of different nebulizers and that breathing simulation should be included as part of their assessment.

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Section: Discussionmentioning

confidence: 87%

Drug output from nebulizers is dependent on the method of measurement

Barry¹,

O’Callaghan²

1998

Eur Respir J

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“…This device combination proved useful for the inhalation of antibiotics. 11 Requirements established by the British Thoracic Society regarding proper techniques were fulfilled. 12 To ensure that the bacteria were killed, a dose of tobramycin 600 mg/day was considered sufficient to reach >10 times the minimum inhibitory concentration (MIC) of tobramycin-susceptible PA in sputum.…”

Section: Methodsmentioning

confidence: 99%

Inhaled Tobramycin in Non—Cystic Fibrosis Patients with Bronchiectasis and Chronic Bronchial Infection with Pseudomonas Aeruginosa

et al. 2005

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“…The nebuliser used (Acorn System 22) is one currently in widespread clinical use for the delivery of antibiotics and bronchodilators in cystic fibrosis. It is well characterized with respect to particle size distribution (77% within the respirable fraction of Ͻ5 m during inspiration) 13 and is thus likely to achieve reasonable particle deposition to the peripheral conducting airways, likely to be targeted for CF gene therapy.…”

Section: Discussionmentioning

confidence: 99%

The effects of jet nebulisation on cationic liposome-mediated gene transfer in vitro

Stern¹,

Sorgi

Hughes³

et al. 1998

Gene Ther

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Nebulisation is currently the most acceptable and practical to the amount of DNA delivered and measurements of both delivery system for repeated applications of gene therapy zeta potential and mean aerodynamic particle size before to the lower airways of cystic fibrosis (CF) patients. We and after nebulisation did not show concentration-related have assessed whether this route of administration offers differences. The increased transfection efficiency did not other benefits with regard to respiratory gene transfer. A relate either to the physical consequences of the nebulisstandard jet nebuliser (Acorn System 22, Medicaid) was ation processes nor the effects of nebulisation on the comused to transfer the reporter gene ␤-galactosidase complexes before instillation. Significantly increased transfecplexed with the cationic liposome DC-Chol/DOPE to three tion efficiency was seen following nebulisation with 95% epithelial cell lines in vitro, two non-CF and one CF, using a O 2 /5% CO 2 in comparison with 21% O 2 /78% N 2 (air); this novel collection system. In all three cell lines, nebulisation did not relate to changes in either the pH or temperature resulted in significantly (P Ͻ 0.05) improved transfection of the solution bathing the cells. The data confirm that nebefficiency compared with instillation. At a constant DNA:liulisation is appropriate for gene delivery to the lower airposome ratio of 1:5 (wt:wt), transfection efficiency was ways in clinical practice and points to factors that may inversely related to increasing concentrations of DNA-lipooptimise gene transfer efficiency. somes before nebulisation. This effect was not related

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Evaluation of two commercial jet nebulisers and three compressors for the nebulisation of antibiotics.

Cited by 18 publications

References 11 publications

Drug output from nebulizers is dependent on the method of measurement

Drug output from nebulizers is dependent on the method of measurement

Inhaled Tobramycin in Non—Cystic Fibrosis Patients with Bronchiectasis and Chronic Bronchial Infection with Pseudomonas Aeruginosa

The effects of jet nebulisation on cationic liposome-mediated gene transfer in vitro

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